1. Zhonghua Yi Xue Za Zhi. 2008 Sep 23;88(36):2578-80.

[Effect of platelet rich plasma on the regeneration of cavernous nerve:
experiment with rats].

[Article in Chinese]

Ding XG, Li SW, Zheng XM, Hu LQ, Hu WL, Luo Y.

Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan 430071, China.

OBJECTIVE: To investigate the effect of platelet rich plasma (PRP) on the
regeneration of injured cavernous nerve (CN).
METHODS: Blood was collected from the hearts of 6 SD rats to prepare PRP. 24 male
adult rats were randomly divided into 3 equal groups: pure suture group
undergoing bilateral CN transaction and pure suture immediately, PRP group
undergoing bilateral CN transaction + suture + PRP 200 microl to the site of
suture, and sham operation group. 3 months later intracavernous pressure (ICP)
was measured by CN electrostimulation and then samples of CN were obtained to
undergo pathological examination.
RESULTS: 3 months later after surgery, the ICP of the pure suture group was (46
+/- 8) cm H2O, significantly lower than that of the sham group [(109 +/- 13) cm
H2O, P < 0.01], and that of the PRP group was (94 +/- 13) cm H2O, significantly
higher than that of the pure sutured group (P < 0.01), however, still
significantly lower than that of the sham operation group (P < 0.05). The number 
of axons of CN in the PRP group was (121 +/- 16), significantly higher than that 
of the pure sutured group (70 +/- 14, P < 0.01); however, still significantly
lower than that of the sham operation group (181 +/- 21, P < 0.01).
CONCLUSION: PRP can promote the regeneration of injured CN and the recovery of
erectile function.

PMID: 19080657  [PubMed - indexed for MEDLINE]