Tag: research

  • New Research Shows Alternative Protocol to be Inferior to the P-Shot® (Priapus Shot®) Procedure

    New Research Shows Alternative Protocol to be Inferior to the P-Shot® (Priapus Shot®) Procedure

    Researchers (Masterson, 2023) recently used a protocol (that differs from the P-Shot® procedure) and measured the effect on erectile function of injections of the penis with platelet-rich plasma (PRP).

    Their protocol was less effective than what previous studies have shown. You can read the article here<–

    Before reviewing their research and their deviations from the P-Shot® protocol, consider what the P-Shot® is: The P-Shot® (Priapus Shot®) is a service mark that names a procedure that requires training in the standard protocol and an agreement to follow the protocol that has been used (with improvements) for the past 13 years.

    The ways Masterson, et al changed the procedure (from that of the P-Shot® procedure) for their study include at least all of the following:

    1. They used a different injection technique than what is used with the P-Shot® procedure; their technique limited the exposure of the penis to less than 1/2 of the tissue treated by the P-Shot® procedure.
    2. They used a centrifuge that is not on the recommended list of devices approved by the FDA for the preparation of PRP for injection back into the body. Their centrifuge also differs from what was used in other studies that showed benefits.  The centrifuge used can have dramatic effects on not only the number of platelets but also the number of white blood cells and red blood cells in the sample–all of which is important in regard to results.
    3. They injected 1/2 the volume of PRP usually injected. They injected a total of 5 cc instead of 10 or more cc’s. So not only did their injection technique limit the distribution, but the volume injected limited the treatment area and the number of platelets.
    4. They did not activate the PRP with Calcium Chloride (or with any agent at all). Without activation, the PRP is more prone to washout, and the growth factors in their 1/2 dose are further limited by being more shortlived than with the P-Shot® procedure. There is a huge difference between the growth factor spectrum and the duration of effect when the activation is modified.
      PRP can be modified by varying leukocyte count, platelet concentration, method of activation, and red blood cell count. (Sheean, 2021)

    Other points about the study:

    1. They calculated sample size based on the assumption that the placebo group would have a 15% rate of attaining MCID, not the observed 50%; so the study was grossly underpowered and conclusions invalid.  Still, we can look at more…


    2. Even though they saw less response (with their altered protocol) than what has been shown in other studies, they still saw improvement in erectile function after injection of PRP; the change was just not significantly greater than saline. Both showed improvement.


    3. Also, what they called a placebo, saline, has been shown to have regenerative properties when injected directly into tissue. When injected iv to compare with a drug, saline is an adequate placebo. When injected into tissue, it has been shown to help improve joint disease and help with leishmaniasis, granuloma annulare, and atrophic acne scars–saline, when injected into soft tissue, is not a placebo.

    “Even when used as a control, saline exerts some therapeutic action in different dermatological indications, including warts, acne scars, and rejuvenation.” (El-Amawy, 2020)


    4. In previous double-blind, placebo studies of PRP for ED, PDE5is were discontinued. In one study, the placebo response (still using saline) was only 15%. Masterson, et al allowed participants to continue their Viagra drugs, which could account for the higher placebo response. The high placebo response also attenuates the power of the study.


    5. The study is also compromised mathematically by a 15% dropout rate in an already small sample size.


    6. In their introduction, Masterson et. al writes the following: “Even without supporting data, numerous clinics in the largest metropolitan areas of the United States are charging patients for PRP treatments for ED.”

    Yet, there IS “supporting data.” Previous studies indeed have shown that PRP does help with ED and with Peyronie’s disease One of those studies was even done by Dr. Ronald Virag, the pioneer in urology who came up with the idea that became “tri-mix” injections for erection and changed urology forever.

    The near disappearance of plaque seen in Peyronie’s disease after injection with PRP (Virag, 2017)

    The authors failed to recognize all of those studies by stating there is “no supporting data.”


    7. They do, later in their discussion, contradict/correct their own statement (“no supporting data”) by making reference to two of many articles that support the P-Shot® procedure and the injection of PRP for ED.

    Then, they reference an article in JAMA that later required a printed correction; but make no reference to the correction, which undermines their point.


    8. Also, the authors fail to point out, in their worries about the money being charged, that the P-Shot® procedure has fewer side effects than Viagra (which has been shown to cause blindness in some) and its cousin drugs and that the cost of a P-Shot® can be less than pharmaceutical alternatives (over time), much less invasive and less expensive than a penile implant, and that P-Shot® providers have agreed to refund the money of anyone not helped by the procedure.

    The P-Shot® in no way makes these alternative treatments not useful and needed. But, the P-Shot® should be part of the tools available for treatment, and a man should be able to try the P-Shot® before proceeding to implant.


    9. Moreover, the Priapus Shot® procedure is NOT just to give a shot. The procedure includes an evaluation to see if the shot is appropriate. There must be phlebotomy (usually another skilled employee’s time and expense) and processing of blood using FDA kits approved for processing blood for autologous reinjection (not cheap). The cost to the patient helps covers these expenses.


    10. Other studies have shown a greater improvement in erectile function than what was seen by these authors. So, we are grateful for their contribution–showing that a different protocol works less well. Further studies are needed to look at the variables regarding the preparation of the PRP, activation, and injection technique to understand further why their protocol was less effective and how current protocols can be improved.

    Some of the supporting data for PRP for the treatment of ED.

    11. Also, further studies are needed regarding combination therapies. For example, one prospective, randomized, controlled study showed that PRP greatly improved the results seen with shock waves for erectile dysfunction.


    In conclusion, Masterson et al demonstrated (in this underpowered study using a placebo that is not a placebo) that injecting 1/2 the volume of the P-Shot® procedure using their alternative technique of injecting and not activating the PRP with CaCl is possibly less effective than what has been shown in other studies. That is valuable to know, and we are grateful for their study.


    To find the nearest P-Shot® (Priapus Shot® provider)<–

    To apply for training for the P-Shot® procedure<–

    Charles Runels, MD

    Charles Runels, MD
    Cellular Medicine Association
    1-888-920-5311
    DrRunels@Runels.com

    References

    References Regarding the Benefits of the P-Shot® Procedure for ED

    Bosma-Den Boer, Margarethe M., Marie Louise Van Wetten, and Leo Pruimboom. “Chronic Inflammatory Diseases Are Stimulated by Current Lifestyle: How Diet, Stress Levels and Medication Prevent Our Body from Recovering.” Nutrition and Metabolism 9 (2012). https://doi.org/10.1186/1743-7075-9-32.

     

    Casabona, Francesco, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, and Ilaria Baldelli. “Autologous Platelet-Rich Plasma (PRP) in Chronic Penile Lichen Sclerosus: The Impact on Tissue Repair and Patient Quality of Life.” International Urology and Nephrology 49, no. 4 (April 2017): 573–80. https://doi.org/10.1007/s11255-017-1523-0.

     

    Chung. “A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction.” Medical Sciences 7, no. 9 (August 29, 2019): 91. https://doi.org/10.3390/medsci7090091.

     

    Chung, Eric. “Medical Sciences A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction,” 2019, 1–11.

     

    Everts, Peter, Kentaro Onishi, Prathap Jayaram, José Fábio Lana, and Kenneth Mautner. “Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.” International Journal of Molecular Sciences 21, no. 20 (October 21, 2020): 7794. https://doi.org/10.3390/ijms21207794.

     

    Garcia, MM, TM Fandel, G Lin, AW Shindel, L Banie, CS Lin, and TF Lue. “Treatment of Erectile Dysfunction in the Obese Type 2 Diabetic ZDF Rat with Adipose Tissue-Derived Stem Cells,” 2010, 14.

     

    Israeli, Joseph M., Soum D. Lokeshwar, Iakov V. Efimenko, Thomas A. Masterson, and Ranjith Ramasamy. “The Potential of Platelet-Rich Plasma Injections and Stem Cell Therapy for Penile Rejuvenation.” International Journal of Impotence Research, November 6, 2021, 1–8. https://doi.org/10.1038/s41443-021-00482-z.

     

    Kumar, C.S. “265 Combined Treatment of Injecting Platelet Rich Plasma With Vacuum Pump for Penile Enlargement.” The Journal of Sexual Medicine 14, no. 1 (January 2017): S78. https://doi.org/10.1016/j.jsxm.2016.11.174.

     

    Lee, Ping-Jui, Yuan-Hong Jiang, and Hann-Chorng Kuo. “A Novel Management for Postprostatectomy Urinary Incontinence: Platelet-Rich Plasma Urethral Sphincter Injection.” Scientific Reports | 11 (123AD): 5371. https://doi.org/10.1038/s41598-021-84923-1.

     

    Liu, Ming-Che, Meng-Lin Chang, Ya-Chun Wang, Wei-Hung Chen, Chien-Chih Wu, and Shauh-Der Yeh. “Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction.” Cells 9, no. 5 (May 19, 2020): 1250. https://doi.org/10.3390/cells9051250.

     

    Matz, Ethan L, Amy M Pearlman, and Ryan P Terlecki. “Safety and Feasibility of Platelet Rich Fibrin Matrix Injections for Treatment of Common Urologic Conditions.” Investigative and Clinical Urology 59, no. 1 (January 2018): 61–65. https://doi.org/10.4111/icu.2018.59.1.61.

     

    Matz, Ethan L., Kyle Scarberry, and Ryan Terlecki. “Platelet-Rich Plasma and Cellular Therapies for Sexual Medicine and Beyond.” Sexual Medicine Reviews 10, no. 1 (January 2022): 174–79. https://doi.org/10.1016/j.sxmr.2020.07.001.

     

    Poulios, Evangelos, Ioannis Mykoniatis, Nikolaos Pyrgidis, Filimon Zilotis, Paraskevi Kapoteli, Dimitrios Kotsiris, Dimitrios Kalyvianakis, and Dimitrios Hatzichristou. “Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.” Journal of Sexual Medicine 18, no. 5 (May 1, 2021): 926–35. https://doi.org/10.1016/j.jsxm.2021.03.008.

     

    Raheem, Amr Abdel, Giulio Garaffa, Tarek Abdel Raheem, Michelle Dixon, Amanda Kayes, Nim Christopher, and David Ralph. “The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie’s Disease.” BJU International 106, no. 8 (2010): 1178–80. https://doi.org/10.1111/j.1464-410X.2010.09365.x.

     

    Ruffo, A., M. Franco, E. Illiano, and N. Stanojevic. “Effectiveness and Safety of Platelet Rich Plasma (PrP) Cavernosal Injections plus External Shock Wave Treatment for Penile Erectile Dysfunction: First Results from a Prospective, Randomized, Controlled, Interventional Study.” European Urology Supplements 18, no. 1 (March 2019): e1622–23. https://doi.org/10.1016/S1569-9056(19)31175-3.

     

    Schirmann, A., E. Boutin, A. Faix, and R. Yiou. “Pilot Study of Intra-Cavernous Injections of Platelet-Rich Plasma (P-Shot®) in the Treatment of Vascular Erectile Dysfunction.” Progrès En Urologie, June 2022, S1166708722001300. https://doi.org/10.1016/j.purol.2022.05.002.

     

    Shaher, Hussein, Abdallah Fathi, Salah Elbashir, Shabieb A. Abdelbaki, and Tarek Soliman. “Is Platelet Rich Plasma Safe And Effective In Treatment Of Erectile Dysfunction? Randomized Controlled Study.” Urology, February 2023, S0090429523000742. https://doi.org/10.1016/j.urology.2023.01.028.

     

    Siroky, Mike B., and Kazem M. Azadzoi. “Vasculogenic Erectile Dysfunction: Newer Therapeutic Strategies.” Journal of Urology 170, no. 2S (August 2003). https://doi.org/10.1097/01.ju.0000075361.35942.17.

     

    Towe, Maxwell, Akhil Peta, Russell G. Saltzman, Navin Balaji, Kevin Chu, and Ranjith Ramasamy. “The Use of Combination Regenerative Therapies for Erectile Dysfunction: Rationale and Current Status.” International Journal of Impotence Research, July 12, 2021, 1–4. https://doi.org/10.1038/s41443-021-00456-1.
    Masterson, Thomas A., Manuel Molina, Braian Ledesma, Isaac Zucker, Russell Saltzman, Emad Ibrahim, Sunwoo Han, Isildinha M. Reis, and Ranjith Ramasamy. “Platelet-Rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.” Journal of Urology, April 30, 2023, 10.1097/JU.0000000000003481. https://doi.org/10.1097/JU.0000000000003481.

    References Regarding P-Shot® Procedure for Peyronie’s Disease

    Culha, Mehmet Gokhan, Erkan Erkan, Tugce Cay, and Uğur Yücetaş. “The Effect of Platelet-Rich Plasma on Peyronie’s Disease in Rat Model.” Urologia Internationalis 102, no. 2 (2019): 218–23. https://doi.org/10.1159/000492755.

     

    Levine, Laurence A. “Peyronie’s Disease: Contemporary Review of Non-Surgical Treatment.” Translational Andrology and Urology 2, no. 1 (2013): 39–44. https://doi.org/10.3978/j.issn.2223-4683.2013.01.01.

     

    Raheem, Amr Abdel, Giulio Garaffa, Tarek Abdel Raheem, Michelle Dixon, Amanda Kayes, Nim Christopher, and David Ralph. “The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie’s Disease.” BJU International 106, no. 8 (2010): 1178–80. https://doi.org/10.1111/j.1464-410X.2010.09365.x.

     

    Virag, Ronald, Hélène Sussman, Sandrine Lambion, and Valérie de Fourmestraux. “Evaluation of the Benefit of Using a Combination of Autologous Platelet Rich-Plasma and Hyaluronic Acid for the Treatment of Peyronie’s Disease.” Sexual Health Issues 1, no. 1 (2017). https://doi.org/10.15761/SHI.1000102.

     

    References Regarding Saline is Not a Placebo

    Asghar, Aneela, Zahid Tahir, Aisha Ghias, Usma Iftikhar, and Tahir Jameel Ahmad. “Efficacy and Safety of Intralesional Normal Saline in Atrophic Acne Scars.” Annals of King Edward Medical University 25, no. 2 (June 24, 2019). https://doi.org/10.21649/akemu.v25i2.2867.

     

    Bagherani, Nooshin, and Bruce R Smoller. “Introduction of a Novel Therapeutic Option for Atrophic Acne Scars: Saline Injection Therapy.” Global Dermatology 2, no. 6 (2016). https://doi.org/10.15761/GOD.1000159.

     

    Bokey, E. L., J. P. Keating, and P. Zelas. “HYDRODISSECTION: AN EASY WAY TO DISSECT ANATOMICAL PLANES AND COMPLEX ADHESIONS.” ANZ Journal of Surgery 67, no. 9 (September 1997): 643–44. https://doi.org/10.1111/j.1445-2197.1997.tb04616.x.

     

    Cass, Shane P. “Ultrasound-Guided Nerve Hydrodissection: What Is It? A Review of the Literature” 15, no. 1 (2016): 3.

     

    “Clinical Benefit of Intra-Articular Saline as a Comparator in Clinical Trials of Knee Osteoarthritis Treatments_ A Systematic Review and Meta-Analysis of Randomized Trials | Elsevier Enhanced Reader.” Accessed April 6, 2022. https://doi.org/10.1016/j.semarthrit.2016.04.003.

     

    El-Amawy, Heba Saed, and Sameh Magdy Sarsik. “Saline in Dermatology: A Literature Review.” Journal of Cosmetic Dermatology 20, no. 7 (2021): 2040–51. https://doi.org/10.1111/jocd.13813.

     

    Popp, Lothar W. “Improvement in Endoscopic Hernioplasty: Transcutaneous Aquadissection of the Musculofascial Defect and Preperitoneal Endoscopic Patch Repair.” Journal of Laparoendoscopic Surgery 1, no. 2 (January 1991): 83–90. https://doi.org/10.1089/lps.1991.1.83.

     

    Saltzman, Bryan M., Timothy Leroux, Maximilian A. Meyer, Bryce A. Basques, Jaskarndip Chahal, Bernard R. Bach, Adam B. Yanke, and Brian J. Cole. “The Therapeutic Effect of Intra-Articular Normal Saline Injections for Knee Osteoarthritis: A Meta-Analysis of Evidence Level 1 Studies.” The American Journal of Sports Medicine 45, no. 11 (September 1, 2017): 2647–53. https://doi.org/10.1177/0363546516680607.

     

    Searle, Tamara, Firas Al-Niaimi, and Faisal R. Ali. “Saline in Dermatologic Surgery.” Journal of Cosmetic Dermatology 20, no. 4 (2021): 1346–47. https://doi.org/10.1111/jocd.13996.

     

    Sharma, ReenaK, Mudita Gupta, and Ritu Rani. “Delineating Injectable Triamcinolone-Induced Cutaneous Atrophy and Therapeutic Options in 24 Patients—A Retrospective Study.” Indian Dermatology Online Journal 13, no. 2 (2022): 199. https://doi.org/10.4103/idoj.idoj_483_21.

     

    References Regarding the Activation of PRP

    Hamilton, Bruce, Johannes L. Tol, Wade Knez, and Hakim Chalabi. “Exercise and the Platelet Activator Calcium Chloride Both Influence the Growth Factor Content of Platelet-Rich Plasma (PRP): Overlooked Biochemical Factors That Could Influence PRP Treatment.” British Journal of Sports Medicine 49, no. 14 (July 1, 2015): 957–60. https://doi.org/10.1136/bjsports-2012-091916.

     

    Kao, David S., Stephanie W. Zhang, and Alexander R. Vap. “A Systematic Review on the Effect of Common Medications on Platelet Count and Function: Which Medications Should Be Stopped Before Getting a Platelet-Rich Plasma Injection?” Orthopaedic Journal of Sports Medicine 10, no. 4 (April 1, 2022): 232596712210888. https://doi.org/10.1177/23259671221088820.

     

    Sheean, Andrew J., Adam W. Anz, and James P. Bradley. “Platelet-Rich Plasma: Fundamentals and Clinical Applications.” Arthroscopy: The Journal of Arthroscopic & Related Surgery 37, no. 9 (September 2021): 2732–34. https://doi.org/10.1016/j.arthro.2021.07.003.

     

    Smith, Oliver J., Selim Talaat, Taj Tomouk, Gavin Jell, and Ash Mosahebi. “An Evaluation of the Effect of Activation Methods on the Release of Growth Factors from Platelet-Rich Plasma.” Plastic and Reconstructive Surgery 149, no. 2 (February 2022): 404–11. https://doi.org/10.1097/PRS.0000000000008772.

     

    Smith, Stephanie A., Richard J. Travers, and James H. Morrissey. “How It All Starts: Initiation of the Clotting Cascade.” Critical Reviews in Biochemistry and Molecular Biology 50, no. 4 (July 4, 2015): 326–36. https://doi.org/10.3109/10409238.2015.1050550.

     

    Toyoda, Toshihisa, Kazushige Isobe, Tetsuhiro Tsujino, Yasuo Koyata, Fumitaka Ohyagi, Taisuke Watanabe, Masayuki Nakamura, et al. “Direct Activation of Platelets by Addition of CaCl2 Leads Coagulation of Platelet-Rich Plasma.” International Journal of Implant Dentistry 4 (August 1, 2018): 23. https://doi.org/10.1186/s40729-018-0134-6.

     

    Ulasli, Alper Murat, Gokhan Tuna Ozturk, Bagdagul Cakir, Gulsemin Erturk Celik, and Fatih Bakir. “The Effect of the Anticoagulant on the Cellular Composition and Growth Factor Content of Platelet-Rich Plasma.” Cell and Tissue Banking, August 28, 2021. https://doi.org/10.1007/s10561-021-09952-6.
  • It’s True! The P-Shot® Procedure Helps Men with Erectile Dysfunction

    Results May Vary. No guarantee of results can be made.

    Sixty men volunteered to have their penis injected with their own blood by eight urologists from Aristotle University in Greece; the results—a double-blind, randomized, placebo-controlled clinical trial published in the May 2021 issue of the Journal of Sexual Medicine—showed that “Platelet-Rich Plasma (PRP) Improves Erectile Function.” More than two-thirds of the men who had their penis injected were pleased with the improvement in their erection and there were zero complications from the procedure. During the study, the sixty men who participated were not allowed to use any other treatments to improve erections.

    Dr. Charles Runels (the inventor of the procedure, which is called the Priapus Shot® or P-Shot®) said, “It’s been a long decade with much resistance, but I’m hoping this new study helps more physicians recognize the potential benefits of the P-Shot® procedure.” 

    On September 12, 2010, Dr. Charles Runels registered his Priapus Shot® (P-Shot®) with the US Patent and Trademark office—announcing that he had found a way to inject platelet rich plasma into the penis to improve the health and function. Since then, multiple studies have been conducted and have shown benefit; but, adoption by urologists has been slow. 

    “We needed this study. I’m a community physician with a small office who just happened to be blessed with the discovery of this therapy more than a decade ago. We have amazing and brilliant providers in multiple universities; but, even they have trouble securing financing for research since the procedure involves the patient’s own blood—there’s no drug, and so there’s no pharmaceutical company to finance the research. If this were a drug, you would see commercials about it on every televised football game—it’s that effective. Until now, surgery and prescription medicines have been the first choice of most urologists and family practitioners; with this procedure, there is not a drug to buy or sell and there’s no surgery. I’m grateful these brilliant physicians from Greece have strengthened the evidence that the P-Shot® should be considered along with the current therapies. Nothing goes away, but this important option should no longer be ignored” said Dr. Runels.

    Dr. Runels also invented the Vampire Facelift® in 2010 and used his observations from that procedure to design the P-Shot® procedure and the O-Shot® procedure—all of which use PRP: which is known to improve the circulation, nerve conduction, and collagen production and so to improve the health of tissue in over thirteen thousand research papers in multiple tissue types.

    “Though these brilliant researchers helped prove the concept of the P-Shot®, their research protocol had to be kept simple to improve the clarity of the conclusions; their published protocol does not include all of the components of the P-Shot® procedure,” said Dr. Runels

    All of those physicians and nurse practitioners who are licensed to perform the P-Shot® procedure (in 55 countries) will be found at PriapusShot.com. Providers not listed there may be performing an inferior procedure or doing the procedure illegally. Dr. Runels and his colleagues of the Cellular Medicine Association, conduct and consult regarding research in the areas of esthetics, erectile dysfunction, urinary incontinence, orgasmic dysfunction, lichen sclerosus, & the treatment of scaring using blood-derived growth factors. 

    “Please beware, serious problems have happened when patients have undergone what was advertised as one of our procedures (Vampire Facelift®, Vampire Facial®, O-Shot®, or P-Shot®) from unlicensed providers who did not follow the protocols of the CMA,” said Dr. Runels.

    Contact:
    Charles Runels, MD
    Medical Director
    Cellular Medicine Association
    888-920-5311 phone
    251-650-1251 fax
    DrRunels@Runels.com
    https://PraipusShot.com
    https://CellularMedicineAssociation.org
    SOURCE Cellular Medicine Association 

    A Double-Blind, Placebo-Controlled study shows that the P-Shot® (Priapus Shot®) works for ED.
    More research about the Priapus Shot® procedure<—
    Find the P-Shot® provider nearest you (50 plus countries)<–
    Apply for training to become a licensed P-Shot® provider<–
  • “P-Long” New Research Underway

    Explanation and Application for Participation in the P-Long Study

    Important good news…
    Even if you cannot participate in the following study, we can still inform you of future studies, if we receive your contact info in the form below…

    Transcript

    Hello, this is Dr. Judson Brandeis board certified urologist.

    Have you ever wished you had a longer penis? Most men do, but some men actually take action and sometimes with disastrous results. At BrandeisMD®, we’re pioneering a new technique for natural and safe penile elongation and girth enhancement. With an IRB-approved, clinical study listed by the National Institutes of Health.

    At other offices, doctors offer subcutaneous injection of fat and other expensive fillers that have to be re-injected every year. Some surgeons cut the suspensory ligament of the penis, right here, but this doesn’t make the penis any longer, it just hangs lower in the locker room and it’s unstable when it’s erect. There’s now even a silicone implant surgically inserted below the skin that makes the penis wider, but not longer and changes the proportion of the head of the penis to the shaft.

    Now I’ve seen many unfortunate complications of all of these procedures and wondered, is there a better way?

    The P-Long Study Uses Four Different Strategies Combined…

    The P-Long study utilizes (1) platelet rich plasma using the protocol of the Priapus Shot® (or P-Shot®) to stimulate the growth of the penis and penile stretching with traction devices to accelerate the process.

    P-Long also uses the (2) Affirm™ nitric oxide booster from AFFIRM Science to help improve penile circulation [as well as instructions and use of both a (3) penile vacuum pump and (4) traction device].

    Is the Study Safe?

    P-Long has institutional review board approval and is listed by the NIH at clinicaltrials.gov. There’s a discounted cost for participating in this study.

    How Do You Apply for Participation in the Study?

    If you wish to be contacted about this or future studies [to improve sexual performance & health] or to learn more about the results [of this study], when we publish them, please provide the information requested below; the application is privacy protected.


    I’m Dr. Judson Brandeis board certified urologist and expert in sexual medicine in San Ramon, California. For more information about me and my office, please visit our website, Brandeismd.com, to learn more about my other four groundbreaking studies and all of the other new developments in the field of sexual medicine.

    Check out and subscribe to my YouTube channel, Instagram and Facebook page [all to be found at] BrandeisMD.

    I hope that I can be of service to you.

    Thank you.

    More details about the study at ClinicalTrials.gov (US National Library of Medicine) click<–

    If you are interested in participating in this or future studies regarding improving male sexual function,
    you may supply your information in the following form.
    You will then be redirected to a page where you can apply for this study and receive information about future studies.
    Since the subject matter regards the penis (which the spam filters often catch), finding the email that will be sent to you and opting in will assure future delivery of our coming opportunities and valuable information about male sexual function.

     

     

    More research regarding the Priapus Shot® (P-Shot®) procedure
    Apply to become a P-Shot® provider
    Find the nearest P-Shot® provider

  • How to treat Peyronie’ s without surgery (new research)

    See review of the research here<–
    And more here<–
    Find nearest certified provider<–
    Apply to become a provider of the Priapus Shot® procedure<–

    IMPORTANT:  The natural progression of Peyronie’s Disease is that it gets worse with time. In other words, if you have Peyronie’s disease and you do nothing, it often worsens with time.

    If you look at the research, though most of the people treated with Priapus Shot® methods got better, some did not get better and some got worse.  The fact that most got better and some got worse does NOT mean conclusively that the procedure made them worse since the disease usually gets worse when left untreated.  Sometimes the Priapus Shot® just does not work and so the disease progresses.  We wish it worked every time in every person –but it does not.

    If your Peyronie’s disease gets worse, after any treatment, most likely it got worse because you have Peyronie’s and that’s what Peyronie’s disease does…the procedure did not work for you. But, your doctor didn’t give you Peyronie’s disease and most likely he/she did not make you worse–the disease did.

    On the other hand, no procedure is without risk and it could be that there are risks to the Priapus Shot® that are unknown to us and/or that occur more frequently than we suspect.  You always have the option to not be treated at all or to choose another treatment.  However, surgery and Xiaflex have their own risks.  Here’s the possibilities with Xiaflex (click to read)<– 

    Dr. Ronald Virag showed that PRP works better and with fewer side effects that Xiaflex (and with less serious side effects), but in the end THERE IS NO PERFECT PROCEDURE.

    Still, we think that the Priapus Shot® is worth trying before going to more other methods (one of the risks of the Priapus Shot® can be that you get a better/harder erection).

    If you do choose to do the Priapus Shot®–after discussion with your physician–we recommend you use the following protocol to increase the chances of your success (click)<–

    Cellular Medicine Association
    1-888-920-5311

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