Category: Peyronie’s Disease

  • New Research Shows Alternative Protocol to be Inferior to the P-Shot® (Priapus Shot®) Procedure

    New Research Shows Alternative Protocol to be Inferior to the P-Shot® (Priapus Shot®) Procedure

    Researchers (Masterson, 2023) recently used a protocol (that differs from the P-Shot® procedure) and measured the effect on erectile function of injections of the penis with platelet-rich plasma (PRP).

    Their protocol was less effective than what previous studies have shown. You can read the article here<–

    Before reviewing their research and their deviations from the P-Shot® protocol, consider what the P-Shot® is: The P-Shot® (Priapus Shot®) is a service mark that names a procedure that requires training in the standard protocol and an agreement to follow the protocol that has been used (with improvements) for the past 13 years.

    The ways Masterson, et al changed the procedure (from that of the P-Shot® procedure) for their study include at least all of the following:

    1. They used a different injection technique than what is used with the P-Shot® procedure; their technique limited the exposure of the penis to less than 1/2 of the tissue treated by the P-Shot® procedure.
    2. They used a centrifuge that is not on the recommended list of devices approved by the FDA for the preparation of PRP for injection back into the body. Their centrifuge also differs from what was used in other studies that showed benefits.  The centrifuge used can have dramatic effects on not only the number of platelets but also the number of white blood cells and red blood cells in the sample–all of which is important in regard to results.
    3. They injected 1/2 the volume of PRP usually injected. They injected a total of 5 cc instead of 10 or more cc’s. So not only did their injection technique limit the distribution, but the volume injected limited the treatment area and the number of platelets.
    4. They did not activate the PRP with Calcium Chloride (or with any agent at all). Without activation, the PRP is more prone to washout, and the growth factors in their 1/2 dose are further limited by being more shortlived than with the P-Shot® procedure. There is a huge difference between the growth factor spectrum and the duration of effect when the activation is modified.
      PRP can be modified by varying leukocyte count, platelet concentration, method of activation, and red blood cell count. (Sheean, 2021)

    Other points about the study:

    1. They calculated sample size based on the assumption that the placebo group would have a 15% rate of attaining MCID, not the observed 50%; so the study was grossly underpowered and conclusions invalid.  Still, we can look at more…


    2. Even though they saw less response (with their altered protocol) than what has been shown in other studies, they still saw improvement in erectile function after injection of PRP; the change was just not significantly greater than saline. Both showed improvement.


    3. Also, what they called a placebo, saline, has been shown to have regenerative properties when injected directly into tissue. When injected iv to compare with a drug, saline is an adequate placebo. When injected into tissue, it has been shown to help improve joint disease and help with leishmaniasis, granuloma annulare, and atrophic acne scars–saline, when injected into soft tissue, is not a placebo.

    “Even when used as a control, saline exerts some therapeutic action in different dermatological indications, including warts, acne scars, and rejuvenation.” (El-Amawy, 2020)


    4. In previous double-blind, placebo studies of PRP for ED, PDE5is were discontinued. In one study, the placebo response (still using saline) was only 15%. Masterson, et al allowed participants to continue their Viagra drugs, which could account for the higher placebo response. The high placebo response also attenuates the power of the study.


    5. The study is also compromised mathematically by a 15% dropout rate in an already small sample size.


    6. In their introduction, Masterson et. al writes the following: “Even without supporting data, numerous clinics in the largest metropolitan areas of the United States are charging patients for PRP treatments for ED.”

    Yet, there IS “supporting data.” Previous studies indeed have shown that PRP does help with ED and with Peyronie’s disease One of those studies was even done by Dr. Ronald Virag, the pioneer in urology who came up with the idea that became “tri-mix” injections for erection and changed urology forever.

    The near disappearance of plaque seen in Peyronie’s disease after injection with PRP (Virag, 2017)

    The authors failed to recognize all of those studies by stating there is “no supporting data.”


    7. They do, later in their discussion, contradict/correct their own statement (“no supporting data”) by making reference to two of many articles that support the P-Shot® procedure and the injection of PRP for ED.

    Then, they reference an article in JAMA that later required a printed correction; but make no reference to the correction, which undermines their point.


    8. Also, the authors fail to point out, in their worries about the money being charged, that the P-Shot® procedure has fewer side effects than Viagra (which has been shown to cause blindness in some) and its cousin drugs and that the cost of a P-Shot® can be less than pharmaceutical alternatives (over time), much less invasive and less expensive than a penile implant, and that P-Shot® providers have agreed to refund the money of anyone not helped by the procedure.

    The P-Shot® in no way makes these alternative treatments not useful and needed. But, the P-Shot® should be part of the tools available for treatment, and a man should be able to try the P-Shot® before proceeding to implant.


    9. Moreover, the Priapus Shot® procedure is NOT just to give a shot. The procedure includes an evaluation to see if the shot is appropriate. There must be phlebotomy (usually another skilled employee’s time and expense) and processing of blood using FDA kits approved for processing blood for autologous reinjection (not cheap). The cost to the patient helps covers these expenses.


    10. Other studies have shown a greater improvement in erectile function than what was seen by these authors. So, we are grateful for their contribution–showing that a different protocol works less well. Further studies are needed to look at the variables regarding the preparation of the PRP, activation, and injection technique to understand further why their protocol was less effective and how current protocols can be improved.

    Some of the supporting data for PRP for the treatment of ED.

    11. Also, further studies are needed regarding combination therapies. For example, one prospective, randomized, controlled study showed that PRP greatly improved the results seen with shock waves for erectile dysfunction.


    In conclusion, Masterson et al demonstrated (in this underpowered study using a placebo that is not a placebo) that injecting 1/2 the volume of the P-Shot® procedure using their alternative technique of injecting and not activating the PRP with CaCl is possibly less effective than what has been shown in other studies. That is valuable to know, and we are grateful for their study.


    To find the nearest P-Shot® (Priapus Shot® provider)<–

    To apply for training for the P-Shot® procedure<–

    Charles Runels, MD

    Charles Runels, MD
    Cellular Medicine Association
    1-888-920-5311
    DrRunels@Runels.com

    References

    References Regarding the Benefits of the P-Shot® Procedure for ED

    Bosma-Den Boer, Margarethe M., Marie Louise Van Wetten, and Leo Pruimboom. “Chronic Inflammatory Diseases Are Stimulated by Current Lifestyle: How Diet, Stress Levels and Medication Prevent Our Body from Recovering.” Nutrition and Metabolism 9 (2012). https://doi.org/10.1186/1743-7075-9-32.

     

    Casabona, Francesco, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, and Ilaria Baldelli. “Autologous Platelet-Rich Plasma (PRP) in Chronic Penile Lichen Sclerosus: The Impact on Tissue Repair and Patient Quality of Life.” International Urology and Nephrology 49, no. 4 (April 2017): 573–80. https://doi.org/10.1007/s11255-017-1523-0.

     

    Chung. “A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction.” Medical Sciences 7, no. 9 (August 29, 2019): 91. https://doi.org/10.3390/medsci7090091.

     

    Chung, Eric. “Medical Sciences A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction,” 2019, 1–11.

     

    Everts, Peter, Kentaro Onishi, Prathap Jayaram, José Fábio Lana, and Kenneth Mautner. “Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.” International Journal of Molecular Sciences 21, no. 20 (October 21, 2020): 7794. https://doi.org/10.3390/ijms21207794.

     

    Garcia, MM, TM Fandel, G Lin, AW Shindel, L Banie, CS Lin, and TF Lue. “Treatment of Erectile Dysfunction in the Obese Type 2 Diabetic ZDF Rat with Adipose Tissue-Derived Stem Cells,” 2010, 14.

     

    Israeli, Joseph M., Soum D. Lokeshwar, Iakov V. Efimenko, Thomas A. Masterson, and Ranjith Ramasamy. “The Potential of Platelet-Rich Plasma Injections and Stem Cell Therapy for Penile Rejuvenation.” International Journal of Impotence Research, November 6, 2021, 1–8. https://doi.org/10.1038/s41443-021-00482-z.

     

    Kumar, C.S. “265 Combined Treatment of Injecting Platelet Rich Plasma With Vacuum Pump for Penile Enlargement.” The Journal of Sexual Medicine 14, no. 1 (January 2017): S78. https://doi.org/10.1016/j.jsxm.2016.11.174.

     

    Lee, Ping-Jui, Yuan-Hong Jiang, and Hann-Chorng Kuo. “A Novel Management for Postprostatectomy Urinary Incontinence: Platelet-Rich Plasma Urethral Sphincter Injection.” Scientific Reports | 11 (123AD): 5371. https://doi.org/10.1038/s41598-021-84923-1.

     

    Liu, Ming-Che, Meng-Lin Chang, Ya-Chun Wang, Wei-Hung Chen, Chien-Chih Wu, and Shauh-Der Yeh. “Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction.” Cells 9, no. 5 (May 19, 2020): 1250. https://doi.org/10.3390/cells9051250.

     

    Matz, Ethan L, Amy M Pearlman, and Ryan P Terlecki. “Safety and Feasibility of Platelet Rich Fibrin Matrix Injections for Treatment of Common Urologic Conditions.” Investigative and Clinical Urology 59, no. 1 (January 2018): 61–65. https://doi.org/10.4111/icu.2018.59.1.61.

     

    Matz, Ethan L., Kyle Scarberry, and Ryan Terlecki. “Platelet-Rich Plasma and Cellular Therapies for Sexual Medicine and Beyond.” Sexual Medicine Reviews 10, no. 1 (January 2022): 174–79. https://doi.org/10.1016/j.sxmr.2020.07.001.

     

    Poulios, Evangelos, Ioannis Mykoniatis, Nikolaos Pyrgidis, Filimon Zilotis, Paraskevi Kapoteli, Dimitrios Kotsiris, Dimitrios Kalyvianakis, and Dimitrios Hatzichristou. “Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.” Journal of Sexual Medicine 18, no. 5 (May 1, 2021): 926–35. https://doi.org/10.1016/j.jsxm.2021.03.008.

     

    Raheem, Amr Abdel, Giulio Garaffa, Tarek Abdel Raheem, Michelle Dixon, Amanda Kayes, Nim Christopher, and David Ralph. “The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie’s Disease.” BJU International 106, no. 8 (2010): 1178–80. https://doi.org/10.1111/j.1464-410X.2010.09365.x.

     

    Ruffo, A., M. Franco, E. Illiano, and N. Stanojevic. “Effectiveness and Safety of Platelet Rich Plasma (PrP) Cavernosal Injections plus External Shock Wave Treatment for Penile Erectile Dysfunction: First Results from a Prospective, Randomized, Controlled, Interventional Study.” European Urology Supplements 18, no. 1 (March 2019): e1622–23. https://doi.org/10.1016/S1569-9056(19)31175-3.

     

    Schirmann, A., E. Boutin, A. Faix, and R. Yiou. “Pilot Study of Intra-Cavernous Injections of Platelet-Rich Plasma (P-Shot®) in the Treatment of Vascular Erectile Dysfunction.” Progrès En Urologie, June 2022, S1166708722001300. https://doi.org/10.1016/j.purol.2022.05.002.

     

    Shaher, Hussein, Abdallah Fathi, Salah Elbashir, Shabieb A. Abdelbaki, and Tarek Soliman. “Is Platelet Rich Plasma Safe And Effective In Treatment Of Erectile Dysfunction? Randomized Controlled Study.” Urology, February 2023, S0090429523000742. https://doi.org/10.1016/j.urology.2023.01.028.

     

    Siroky, Mike B., and Kazem M. Azadzoi. “Vasculogenic Erectile Dysfunction: Newer Therapeutic Strategies.” Journal of Urology 170, no. 2S (August 2003). https://doi.org/10.1097/01.ju.0000075361.35942.17.

     

    Towe, Maxwell, Akhil Peta, Russell G. Saltzman, Navin Balaji, Kevin Chu, and Ranjith Ramasamy. “The Use of Combination Regenerative Therapies for Erectile Dysfunction: Rationale and Current Status.” International Journal of Impotence Research, July 12, 2021, 1–4. https://doi.org/10.1038/s41443-021-00456-1.
    Masterson, Thomas A., Manuel Molina, Braian Ledesma, Isaac Zucker, Russell Saltzman, Emad Ibrahim, Sunwoo Han, Isildinha M. Reis, and Ranjith Ramasamy. “Platelet-Rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.” Journal of Urology, April 30, 2023, 10.1097/JU.0000000000003481. https://doi.org/10.1097/JU.0000000000003481.

    References Regarding P-Shot® Procedure for Peyronie’s Disease

    Culha, Mehmet Gokhan, Erkan Erkan, Tugce Cay, and Uğur Yücetaş. “The Effect of Platelet-Rich Plasma on Peyronie’s Disease in Rat Model.” Urologia Internationalis 102, no. 2 (2019): 218–23. https://doi.org/10.1159/000492755.

     

    Levine, Laurence A. “Peyronie’s Disease: Contemporary Review of Non-Surgical Treatment.” Translational Andrology and Urology 2, no. 1 (2013): 39–44. https://doi.org/10.3978/j.issn.2223-4683.2013.01.01.

     

    Raheem, Amr Abdel, Giulio Garaffa, Tarek Abdel Raheem, Michelle Dixon, Amanda Kayes, Nim Christopher, and David Ralph. “The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie’s Disease.” BJU International 106, no. 8 (2010): 1178–80. https://doi.org/10.1111/j.1464-410X.2010.09365.x.

     

    Virag, Ronald, Hélène Sussman, Sandrine Lambion, and Valérie de Fourmestraux. “Evaluation of the Benefit of Using a Combination of Autologous Platelet Rich-Plasma and Hyaluronic Acid for the Treatment of Peyronie’s Disease.” Sexual Health Issues 1, no. 1 (2017). https://doi.org/10.15761/SHI.1000102.

     

    References Regarding Saline is Not a Placebo

    Asghar, Aneela, Zahid Tahir, Aisha Ghias, Usma Iftikhar, and Tahir Jameel Ahmad. “Efficacy and Safety of Intralesional Normal Saline in Atrophic Acne Scars.” Annals of King Edward Medical University 25, no. 2 (June 24, 2019). https://doi.org/10.21649/akemu.v25i2.2867.

     

    Bagherani, Nooshin, and Bruce R Smoller. “Introduction of a Novel Therapeutic Option for Atrophic Acne Scars: Saline Injection Therapy.” Global Dermatology 2, no. 6 (2016). https://doi.org/10.15761/GOD.1000159.

     

    Bokey, E. L., J. P. Keating, and P. Zelas. “HYDRODISSECTION: AN EASY WAY TO DISSECT ANATOMICAL PLANES AND COMPLEX ADHESIONS.” ANZ Journal of Surgery 67, no. 9 (September 1997): 643–44. https://doi.org/10.1111/j.1445-2197.1997.tb04616.x.

     

    Cass, Shane P. “Ultrasound-Guided Nerve Hydrodissection: What Is It? A Review of the Literature” 15, no. 1 (2016): 3.

     

    “Clinical Benefit of Intra-Articular Saline as a Comparator in Clinical Trials of Knee Osteoarthritis Treatments_ A Systematic Review and Meta-Analysis of Randomized Trials | Elsevier Enhanced Reader.” Accessed April 6, 2022. https://doi.org/10.1016/j.semarthrit.2016.04.003.

     

    El-Amawy, Heba Saed, and Sameh Magdy Sarsik. “Saline in Dermatology: A Literature Review.” Journal of Cosmetic Dermatology 20, no. 7 (2021): 2040–51. https://doi.org/10.1111/jocd.13813.

     

    Popp, Lothar W. “Improvement in Endoscopic Hernioplasty: Transcutaneous Aquadissection of the Musculofascial Defect and Preperitoneal Endoscopic Patch Repair.” Journal of Laparoendoscopic Surgery 1, no. 2 (January 1991): 83–90. https://doi.org/10.1089/lps.1991.1.83.

     

    Saltzman, Bryan M., Timothy Leroux, Maximilian A. Meyer, Bryce A. Basques, Jaskarndip Chahal, Bernard R. Bach, Adam B. Yanke, and Brian J. Cole. “The Therapeutic Effect of Intra-Articular Normal Saline Injections for Knee Osteoarthritis: A Meta-Analysis of Evidence Level 1 Studies.” The American Journal of Sports Medicine 45, no. 11 (September 1, 2017): 2647–53. https://doi.org/10.1177/0363546516680607.

     

    Searle, Tamara, Firas Al-Niaimi, and Faisal R. Ali. “Saline in Dermatologic Surgery.” Journal of Cosmetic Dermatology 20, no. 4 (2021): 1346–47. https://doi.org/10.1111/jocd.13996.

     

    Sharma, ReenaK, Mudita Gupta, and Ritu Rani. “Delineating Injectable Triamcinolone-Induced Cutaneous Atrophy and Therapeutic Options in 24 Patients—A Retrospective Study.” Indian Dermatology Online Journal 13, no. 2 (2022): 199. https://doi.org/10.4103/idoj.idoj_483_21.

     

    References Regarding the Activation of PRP

    Hamilton, Bruce, Johannes L. Tol, Wade Knez, and Hakim Chalabi. “Exercise and the Platelet Activator Calcium Chloride Both Influence the Growth Factor Content of Platelet-Rich Plasma (PRP): Overlooked Biochemical Factors That Could Influence PRP Treatment.” British Journal of Sports Medicine 49, no. 14 (July 1, 2015): 957–60. https://doi.org/10.1136/bjsports-2012-091916.

     

    Kao, David S., Stephanie W. Zhang, and Alexander R. Vap. “A Systematic Review on the Effect of Common Medications on Platelet Count and Function: Which Medications Should Be Stopped Before Getting a Platelet-Rich Plasma Injection?” Orthopaedic Journal of Sports Medicine 10, no. 4 (April 1, 2022): 232596712210888. https://doi.org/10.1177/23259671221088820.

     

    Sheean, Andrew J., Adam W. Anz, and James P. Bradley. “Platelet-Rich Plasma: Fundamentals and Clinical Applications.” Arthroscopy: The Journal of Arthroscopic & Related Surgery 37, no. 9 (September 2021): 2732–34. https://doi.org/10.1016/j.arthro.2021.07.003.

     

    Smith, Oliver J., Selim Talaat, Taj Tomouk, Gavin Jell, and Ash Mosahebi. “An Evaluation of the Effect of Activation Methods on the Release of Growth Factors from Platelet-Rich Plasma.” Plastic and Reconstructive Surgery 149, no. 2 (February 2022): 404–11. https://doi.org/10.1097/PRS.0000000000008772.

     

    Smith, Stephanie A., Richard J. Travers, and James H. Morrissey. “How It All Starts: Initiation of the Clotting Cascade.” Critical Reviews in Biochemistry and Molecular Biology 50, no. 4 (July 4, 2015): 326–36. https://doi.org/10.3109/10409238.2015.1050550.

     

    Toyoda, Toshihisa, Kazushige Isobe, Tetsuhiro Tsujino, Yasuo Koyata, Fumitaka Ohyagi, Taisuke Watanabe, Masayuki Nakamura, et al. “Direct Activation of Platelets by Addition of CaCl2 Leads Coagulation of Platelet-Rich Plasma.” International Journal of Implant Dentistry 4 (August 1, 2018): 23. https://doi.org/10.1186/s40729-018-0134-6.

     

    Ulasli, Alper Murat, Gokhan Tuna Ozturk, Bagdagul Cakir, Gulsemin Erturk Celik, and Fatih Bakir. “The Effect of the Anticoagulant on the Cellular Composition and Growth Factor Content of Platelet-Rich Plasma.” Cell and Tissue Banking, August 28, 2021. https://doi.org/10.1007/s10561-021-09952-6.
  • Peryronie’s Disease Personal Video Story from Brave Man

    Brave Man Tells His Story about Treatment of Peyronie’s Disease with the Priapus Shot® [P-Shot®] Procedure
    *Results May Vary*

    Transcript

    Meet Dr. Shanthala<–

    Dr. Shanthala Shivananjappa

     

     

     

     

     

     

     

     

    Doug Brown: Hi, I’m Doug Brown. I’m here at Dr. Shanthala, MD’s office, and I’m here to have a procedure for something that most men or most people don’t even understand, which is called Peyronie’s disease.

    Peyronie’s is a condition that happens over time for most men, and quite frankly it’s a little embarrassing. But it’s where the penis actually starts to have a curvature to it, and it happens gradually over time. And many men are embarrassed by it and many men don’t understand what it’s all about because it’s happening and they’re trying to figure out, well, why is this happening to me? That’s what was happening, as well, to myself.

    And so I was seeking out multiple treatments, and, frankly, there wasn’t a lot that I could find online, at the time. And then I would find things of, you know, magic potions and magic pills, and those wouldn’t work, and different types of contraptions that people wanted to sell.

    I eventually decided that I was going to just take the medical route, and so I went and had a couple of injections of what they call Xiaflex, and Xiaflex is kind of an enzyme that eats away. What happens is plaque gets underneath the skin. It’s due to either an injury or sometimes an allergic reaction, it’s really kind of what the medical community calls idiopathic. It’s really not a cause that somebody really understands why this happens.

    And it’s been interesting to me because, you know, now that I’ve had the issue and I’ve talked to other people, and they now know they have the issue, but they didn’t even know what it was, so as I was progressing through this process with the Xiaflex, I actually got some results.

    The Xiaflex are a series of injections. However, they’re very, very costly. Too little vials of medication are actually $9,000 from the pharmacy, and so I had a couple of those, but then the insurance wouldn’t support it any longer. So I was looking for other alternatives, because even though I got some results from it, I wanted more of a natural type of process. Because while I went through those, I had things called hematoma, which is where the blood vessels sort of burst with inside the skin, or it felt like that anyways, and things would swell. And it was very painful.

    Anyways, I’m here because I went through what is called the P-shot. And the P-shot is a process where they use your own natural blood and what they call PRP, I believe it’s called, and what that does is it goes in and it actually does a similar thing that the Xiaflex does. However, it’s not a series of multiple injections that you have to go through, and there’s no adverse reaction to it.

    So I had one done already, and immediately I started noticing a vast change, and for the positive. So, where the curve was still a good sized curve, it started straightening out immediately on all angles. And so it’s been very successful for me, and so I’m back to have another one, because I got better results this time, the first time, and I want to have better results the second time.

    So the good thing about the PRP and the P-shot versus the Xiaflex, for myself, was not only do you not have to have insurance get involved, but number two, it’s very quick. So the time recovery on the P-shot versus the Xiaflex shot, the recovery time was instantaneous. Really, that day. It wasn’t painful after that. It was very straightforward.

    But with the Xiaflex, you do it in one day and then you got to wait a couple of days and you go back again, and they’re constantly … I’ll just, for the lack of better terms, using an invasive type of process, and so there is a week to four week recovery time. And what I noticed with the P-shot was the recovery time was instantaneous. I was recovered that day, and back to normal function.

    And so, you know, I’m here to talk about this because most men, frankly, they don’t want to talk about it. It’s kind of embarrassing to them. And, you know, this happens to a lot more men than people know.

    So I’m here to answer a series of questions as well, so there may be some questions thrown to me at this point.

    Speaker 2: Well, Doug, thank you very much for talking. I appreciate it. Very well said. I was just wondering, does this hurt? Do you have any pain when you’re having the procedure done?

    Doug Brown: No, I mean, because they’re numbing up the area, you do feel a slight pinch when the needle is inserted, but it’s not painful. At least it wasn’t for me. And I don’t think it’s anything worse than what I would consider maybe a mosquito bite or a bite like that.

    And then once the pinch is gone, I didn’t feel a thing, honestly.

    Speaker 2: How many shots do you think would be optimal to get the results that you desire?

    Doug Brown: Well, I think it depends on the person’s condition. You know, I’ve talked to men who have slight curvature, and unfortunately, the more curvature that one has, then it’s a challenge with all kinds of function, whether it’s sexual function or also urinary function as well. I was running into that in the beginning. And that’s one of the reasons I just said … you know, I didn’t know about the P-shot before, so I just went to the Xiaflex ’cause that was the only thing that medical doctors who are traditionalists would recommend.

    So, you know, I got results in my first P-shot, so for me, I’m back because I want more results, but I noticed an immediate straightening and I noticed an immediate … I used to have an indenture on both sides where the curvature was happening, and they both went away within an hour. You know, I was like, wow, what happened. And now, the reason I’m back is because over time the indenture on the left is completely gone and the one on the right is slightly back, so I want to get rid of that as well.

    The other thing that I noticed immediately, I noticed a size increase immediately. So length and girth, width, as well. So, you know, for me, it was pretty immediate. But I think most men probably should look, you know, between one and four treatments, probably on average, to make it work out right.

    And the reality is, when you compare it against the other, even with co-pays on insurance, what I have found is this is much more economical, and the recovery time … I mean, the second Xiaflex shot I had, I mean, it took me about four weeks to recover. So, and you know, it was painful for about two weeks.

    Speaker 2: Did you feel that you had your privacy respected when you came into the office?

    Doug Brown: Here?

    Speaker 2: Yes, yes.

    Doug Brown: Oh, yeah, absolutely. Yeah, they’re … you know, I’m kind of a, like, you know, I’m not really that modest anyways. Probably one of the reasons I’d be willing to do this and that. But I do understand that many men, you know, in different professions, and I sort of have a public persona profession so to do this is actually a stretch for me, but I think it’s so important that, you know, a lot of men, or a lot of guys out there, they’re suffering with this condition and, you know, it’s affecting their whole life. It was affecting my whole life. And I think that the privacy here was respected as well as anywhere I’ve ever been. In fact, better so.

    What I got here is, you know, in the other medical community, because they’re dealing with insurance companies and they’re running people through the mill and they’ve got such a high overhead on a lot of things, there wasn’t, I would say, that personalization that I got here, by any means.

    You know, sometimes I would have to wait an hour to get in for the procedure on the other place, or, you know, a couple of times the doctor was so busy because they were out on call all night long, they were sleeping, they couldn’t even get back to the office, so I had to go back a couple of times. And it was and hour drive for me, because there’s not a lot of people who actually do this type of treatment, and so, you know, certainly, it’s more far and few between.

    So when I found this, and I found it in my local area, I was like, you know what, I’m going to give it a shot, and I’m very grateful I did.

    Research supporting the use of the P-Shot® for Peyronie’s disease (and how it works better then Xiapex)<–

    More research supporting the above man’s  brave story<–

    The full P-Shot® protocol for the treatment of Peyronie’s Disease<–

    Find nearest P-Shot® provider<–

    Apply to become provider of the Priapus Shot® [P-Shot®] procedure<–

  • Priapus Shot® for Improved Sexual Function. Vegas 2018

    International Society for Cosmetogynecology<–

    Cellular Medicine Association<–

    Transcript

    Dr. Marco Pelosi III: Our next speaker is probably best described as the Michael Jordan of platelet rich plasma, Dr. Charles Runels from Alabama, that pioneered the O-Shot® [Orgasm Shot®], the Vampire [Face]lift®, the P-Shot® [Priapus Shot®], and he’s taken all the abuse and he’s given the world some very, very useful procedures for everyone. He’s going to talk about the studies he did and the studies done in platelet rich plasma in regards to sexual function. Dr. Runels, it’s a pleasure to have you here.

    Dr. Runels: Thank you for having me.

    I’m going to go through a whirlwind look at research that’s been done where people have used PRP to help with sex. Much of the research has been done by the people in our group, and I’ve described many of them in this room who have done this research. It’s a for-profit organization, but we pay for research, we pay for education, we pay for marketing for our providers. Just to echo what you just heard, sex is much more than about just having fun. Rainer Maria Rilke said it’s just so correlated to the creative experience that it’s affecting how we do our work, how you do your presentation, and how – of course – relationships and families.

    I want to echo that sentiment, and remind us that back in 1980, if you look in ‘Urology’ – this was ‘Urology’ 1980 – the most common cause for erectile dysfunction was thought to be 85% psychogenic. Here’s a quote from ‘Urology’ where urologists were encouraged to become counselors, because most of erectile dysfunction was thought to be psychogenic. Of course, I’m echoing the penis stuff because if you take a penis and shrink it and unzip it, that becomes a clitoris. I’m thinking most of the research will eventually apply to that. Certainly, our attitude is applying because we’re back in the … We’re not, I’m preaching to the choir, but many of our colleagues are back in the 1980’s and saying the main thing we have for sexuality for women is counseling.

    My thinking that perhaps, as you guys do, some of the pathology that applies to the penis may apply to the clitoris, and maybe some of these women are suffering from actual genital histopathology, not just psychogenic problems. We have this one FDA approved drug now for female sexual dysfunction that’s a psych drug, flibanserin. It’s a useful drug, but obviously, we need much more and maybe we should think in terms of systems, like we do for the rest of the body.

    Platelet Rich Plasma.

    Obviously, this is not a new idea. This is from, this month, over 9,000 papers indexed in PubMed about platelet rich plasma. Our orthopedic colleagues, our dentist, our facial plastic surgeons have worked with this, and all we have to do is take their ideas and then hopefully people in this room will extend what I’m about to show you and just take those ideas and adapt them to the genital space. Here’s some of the growth factors we know about. There are many more. They have these effects. These are good things for the genitalia. Down-regulating autoimmune response, proliferation of fibroblasts, new angiogenesis, the adipocytes enlarge and multiply – think labia majora, collagen production, neurogenesis and maybe some glandular function.

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    There’s never, in all those 9,000 papers, I still cannot find one serious side effect. No granulomas, no serious infection. PRP is what your body makes to heal when you do your surgeries and help prevent infection. Obviously, there are always certain things that can happen, bruising and such, but if you have a serious life-threatening complication from PRP, you will have the first recorded in all of that 9,000 plus papers. That’s a nice thing.

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    We have commercially available methods for preparing it, within 5 or 10 minutes of the bedside, and the devices are FDA approved. So you guys don’t get confused, obviously the FDA does not approve your procedures. That’s a doctor business. They don’t approve blood that belongs to you, just like your spit and your saliva and your skin. They tried, at one time, to control eggs and the gynecologists said, “Hell no.” So they don’t control eggs and they don’t control blood, but you should use an FDA approved device if you do this [approved for preparation of PRP to go back into the body].

    Autoimmune Disease

    Here’s some of the ideas about down-regulating autoimmune response. We have split-scalp studies showing that PRP helps alopecia areata better than triamcinolone. More hair growth that comes in thicker. Here’s rat studies looking at rheumatoid arthritis. What do we have in the genital space? We have lichens sclerosus. We did some before and after pictures where you use stem cells mixed with PRP, and before and after pictures show improvement. Of course, that’s two variables because you have stem cells and you have the PRP.

    We took the same idea and just used PRP. Andrew Goldstein worked with me on this, and we had two blinded dermatopathologists. The protocol was biopsy, PRP, wait six weeks later, another PRP injection, and then six weeks after that, another biopsy. Two blinded dermatopathologists out of George Washington University did not know the before or the after. We showed statistical improvement in both the histology and symptomatology. Here’s our histology. You can see obviously, that’s the same magnification and we’re showing decreased hyperkeratosis. That’s obviously healthier tissue. A layperson could tell that’s better. Of course if you look at the gross pictures, lady on the left as you guys know, she has pain wearing her blue jeans. The lady on the right is back to making love to her husband. They’ve invited me into their close Facebook groups and I saw a post a few months ago. Quote says, “I was sitting next to my husband, whom I love, last night. I was afraid to hold his hand because I was afraid he would become aroused and I’m bleeding and hurting today.” That’s what you guys are helping.

    We published that in ‘Lower Genital Tract Disease’. We extended it because it worked. We published this past January in the journal of the American Academy of Dermatology. You have some science to go do this now.

    One of our providers, Kathleen Posey, who’s a gynecologist out of New Orleans, took this idea and then she said, “Let’s do some dissection in the office”, and she presented this in Argentina, published it in the same journal ‘Lower Genital Tract Disease’. Here’s one of her patients, where you can introduce [inaudible 00:06:44]. It had been 12 years since she had had sexual intercourse, penis and vagina intercourse, with her loving husband … 12 years. She was being followed by a dermatologist on high dose clobetasol. Kathleen dissected it out in the office and then injected PRP … 8 weeks later, she’s having comfortable sex with her husband. She’s now 3 years out. She’s had to be treated with PRP, not repeat surgery … PRP now, 2 other times a year apart to maintain that result. She now has a series of 60 or so patients that she’s now going to publish with similar results, where she’s dissecting out – as you guys know how to do – treating the [inaudible 00:07:27], but then following that with PRP injections to help the healing and decease the autoimmune response.

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    That same doctor, Casabona, repeated his study with lichen sclerosus in men [BXO], and showed with just PRP alone … This study of 45 men with repeat treatments … It is cumulative, 2 to 10 treatments, the same thing. All of them stopped their steroids. None of them started back. Only one went on to have circumcision.

    Peyronie’s

    Peyronie’s disease, another autoimmune disease … This came out this month out of Wake Forest, where they took men and they followed their results with Peyronie’s disease. Not only did their Peyronie’s improve statistically, but they also improved their erectile dysfunction by 5 on that scale of 5 to 25 that the urologists use. For some reason, thankfully, they threw in one woman just for good measure, and showed that it helped her incontinence. They just tucked that in as an aftermath.

    Ronald Virag, as you guys know as the legendary vascular surgeon who was first to present the idea of intracavernosal injections for erectile dysfunction, out of Paris. His big thing now is PRP for Peyronie’s. He just published a study where he showed that this is comparing PRP with Xiapex, which is a $50,000 series of injections, FDA approved version of collagenase. He showed that PRP works better with few side effects. There’s a risk of about 1 in 30, that actually go from a bent pencil to a fractured pencil and a limp noodle. You don’t see that with PRP. You see the side effect is the erectile function improves. He showed the same thing, actually, in his studies that erectile dysfunction improves by an average of about 7 on that 5 to 25 point scale.

    Wound Healing/Scar Resolution

    Let’s think about the [inaudible 00:09:29] literature. Look at this, there’s so much of this out there. This is looking at post-operative adhesions, lots of studies looking at scarring with microneedling and PRP. This is a split-face study comparing PRP with microneedling verus PRP … Excuse me, microneedling with saline or Vitamin C serum and split-faced studies in PRP wins. Dr. Sclafani did some studies in the cosmetic space looking at increased collagen production and fibroblast activity, and never a neoplasia documented. People worry about that. This is not indiscriminate blindness blind growth. You don’t worry about carcinogenesis when you do surgery and it’s the same PRP that’s causing healing. There’s actually some helpful immune processes that go on, that you could argue actually might help prevent cancer. I’m not going to make that argument but it might need to be made one day.

    If you look further, here’s a wound healing study looking at reepithelialized exposed bone and tendon of the foot and ankle. When I took that and applied, this is a hypertrophic scar that was a year old from cortisone, and then using PRP and Juvederm or HA filler, this is a few days later, a month later, and that’s a year later. Now, take that and think, “How could I use that in the genitourinary space?” Doing that anecdotally, we have many of the members of our group are seeing help with episiotomy scars or dyspareunia, pelvic foreplay instead of injecting that pelvic floor tenderness with triamcinolone. Physiatrist for the past ten years has been using PRP, your sports medicine doctors. Now, when you palpate it, consider injecting with PRP instead. Dyspareunia from mesh and that unknown dyspareunia, we’re seeing this is where we need you guys to help extend the research. The science is there that it should help and it seems to be helping. Not 100%, but about 80% in people with dyspareunia.

    Mesh Pain

    Here is a look at a gentleman who did … He took the mesh out and then he patched the hole with a gel form of PRP and showed benefit. We’re finding anecdotally – no one’s done this study yet, here’s another one for you to pick up … I’m giving you low hanging fruit. We’re seeing anecdotally that if you inject in the distribution of the pudendal nerve, which seems to be inflamed in some women with mesh pain, that their pain will frequently go from 9 out of 10 down to 1 or 2 out of 10, without even taking the mesh out. Just another place where we need some research done.

    Interstitial Cystitis

    Here, we have rat studies looking at inflammation. Let’s think about this one. Here’s a rat study where they modeled cystitis and we are seeing in chronic interstitial cystitis without even infiltrating the bladder, just infiltrating in the periurethral space, some of our women are getting better. I’ve had two separate urologists call me and say, “Charles, I can’t believe it. I was doing this and expecting not this to happen. I have these patients now who have had chronic interstitial cystitis pain for years, and it’s gone.” Not 1005 but finding out who’s going to respond and who’s not and why, there’s a lot of variables that need to be thought about that you guys will hopefully do the research.

    Penis Growth

    Here’s a study that came out in the ‘Journal of Sexual Medicine’, where a guy took … the [inaudible 00:12:51] men who have an erection of 3 inches or less and then he treated them with PRP, combined with a pump, and showed that if you repeated it every time you did it, it grew by about 7 millimeters. I’ve always thought if I could give you a guarantee half an inch to an inch with anything, I’d get my picture on a postage stamp. I don’t have that yet, but I can tell you that we’re seeing about 60% of the time we do this procedure, men will see some sort of growth.

    If you look at the neovascular space, there was a study out of Southern California that was published in the ‘Journal of Sexual Medicine’ where they transferred adipocyte stem cells to the penis of diabetic rats. They showed new endothelial cell growth and increased nitric oxide activity in the dorsal nerve. Would that be helpful in the clitoris? Probably, but the interesting thing is the adipocyte-derived stem cells were attacked and they died. The postulate was the improvement was from the growth factors.

    Penile Rehabilitation and Erectile Dysfunction

    I have seen what [inaudible 00:13:52] have seen in that when you inject this in the penis, erectile function goes up on the average of about 5 to 7 per injection. Think about nerve repair. We have rat studies modeling prostrate surgery, showing that the nerves improved with PRP and so we have, again, another clear place where we need studies if you add this now to the usual protocol for rehabilitating the penis post-prostate surgery … would you see benefit? We have seen that in some of our patients who are a year or two out who failed the rehabilitation part of that. Would that help your patients who have, say, numbness and decreased function from riding their bikes too much, or trauma? I don’t know, but it’s worth thinking about and publishing research about.

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    In thinking about where to put this, where we do our O-Shot, when we do PRP to the anterior vaginal wall, we’re putting it as distal from the bladder as possible. We found that it works better. We’re essentially making a liquid sling. Think infiltrating and getting ready to put in the mesh. That’s what we’re doing. Very simple, only we’re using a material that has never caused a granuloma ever. Doing that, frequently our patients will have their incontinence go away that day from the actual liquid and as it’s replaced with new tissue, it never recurs. Usually, you’ll have to repeat the procedure at a year or two out depending on the etiology. Sometimes it lasts longer.

    The interesting idea is what might be happening with those [inaudible 00:15:21]. They become more active, and does that help with sexual function? The other place we put it is in the actual corpus cavernosum of the clitoris. We use [inaudible 00:15:29] ultrasound visualization and see it flow down into the body of the clitoris by the pubic ramus and the wave form goes to what you see in a flaccid penis to what you see in an erect penis.

    Improved Orgasm & Libido in Women

    That’s my time, almost done. Just 30 more seconds. Here’s a pilot study we did where we showed that in women with female sexual distress, that it dropped by an average of 10 and female sexual function went up by 5 when you do what I just showed you. Here’s a study that Dr. Neto, who may be here, published where he looked at incontinence and sexual function down in Brazil and showed that 94% of the people loved it. The question here is how would you combine it with your energy source? It works great in the face if you do laser and follow it with PRP … better results, faster healing. Is it going to … We need people to help us work out the algorithms. Not everybody has laxity, but when you have something, when do you use which treatment and when do you combine it with PRP? We need those answers, because I don’t have them yet. This is possible helps.

    I am done. Thank you very much for having me. I put all these references at that website, if you want to go download them. Thank you. You guys have a wonderful conference.

    Dr. Marco Pelosi III: Thank you Charles. Beautiful

    More about the Cellular Medicine Association

    O-Shot® Research<–
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  • Vegas2017

    Personal note from the inventor of the PRIAPUS SHOT® procedure…

    for physicians, nurse practitioners, sex educators, & physician’s assistants…

    Hello,

    Though I was the first physician in the world to use PRP to rejuvenate the human penis, though I invented the Priapus Shot® procedure, I count that as worthless unless many physicians and nurse practitioners actually learn to do the procedure and offer it to suffering men around the world.

    Inventor of the O-Shot (R) Procedure
    Charles Runels, MD
    Inventor of the Priapus Shot® Procedure

    If you are interested in learning about the procedure and applying to offer this procedure to your patients, please supply the following information. Partial information will not receive a response because I will not be able to check your credentials.

    Sex educators (and counselors) are critical to the healing process and I would be honored to also supply information to you (only physicians and their extenders can do the procedure since the procedure involves phlebotomy and injection of blood-derived growth factors).

    Thank you very much for your interest! I look forward to talking with you.

    Peace & health,

    signature-md

     

     

    Charles Runels, MD

    Please provide the following info so that I might send material to you immediately…

    • Watch a video describing how the Priapus Shot® procedure benefits both patients and providers
    • Free research about the Priapus Shot® mailed to your office.
    • Supporting scientific literature reviewed by video and with electronic file.
    • Access to my personal cell phone to answer your questions.

    Save

    Apply to Become Provider of the Priapus Shot® (P-Shot®) Procedure

  • When Should You Treat Peyronie’s with the P-Shot® Procedure…Early After Onset, or Later?

    Question (name changed)…

    Dr. Runels:

    I’m an ENT doctor but in this case a urology pt with recent-onset (noticed 2-3 weeks ago) Peyronie’s. My urologist ______ in ______ gave me your flier about the Priapus Shot® treatment.

    (1) Does your Rx address the plaques?

    (2) Does it stop or reverse the Peyronie’s process?

    (3) Is it better to treat early (now) or wait 8-10 months when the plaques stabilize?

    Thank you.

    Answer:

    (1) Yes! Research shows a decrease in plaque size.
    (see research listing below)

    (2) If you mean, does the Priapus Shot® procedure help the curvature? Yes, in most men.  If you mean, does it permanently reverse the underlying process so the curvature never recurs…then probably in some. To further elaborate with some data, we did the following research (click to read) with lichen sclerosus (also thought to be an autoimmune process, like Peyronie’s), showing that our process with the O-Shot® procedure decreased inflammation according to 2 blinded dermatopothologists–indicating that somehow the procedure down-regulates the autoimmune response.  There are other papers showing this downregulation of the autoimmune process by PRP.

    Further as to permanence, our provider group has seen women who see a recurrence of their lichen at 1 year out, a few who are not helped at all, and many who are still well at 3-4 years post procedure. How these data will relate to Peyronie’s disease remains to be seen but we expect a similar spectrum.
    (see research listing below)

    (3) DEFINITELY  better to treat early  before the scar tissue matures. I saw Dr. Virag lecture in Venice this past summer when we shared the podium and he will soon publish data showing that using PRP is more effective and safer than Xiaflex. Depending on how you look at the data, Xiaflex has a 1 in 50 to 1 in 100 risk of fracture/impotence post procedure. The Priapus Shot® procedure has associated with it the probable side effect of an improvement in erection quality by around 5 – 7 on the 25 point scale commonly used.
    (see research listing below)

    IMPORTANT! If your provider is not on the following list of physicians who have studied the accepted methods of the Priapus Shot® procedure (click) and agreed to follow them, then your physician may be a wonderful provider, but I have no way of knowing who or how he/she was trained and what method he learned. So, I have NO way to make any comments about the quality of the procedure he/she may provide. What I can say, is that your physician (if she/he says he’s providing the P-Shot® but is not listed on that directory) is either knowingly or unknowingly breaking the law and pretending to be part of a group that he/she is NOT a part of. The certified providers of the Priapus Shot® procedure share notes with each other, finance research, and support the advancement of the effectiveness of the procedure. THOSE WHO USE THE NAME “PRIAPUS SHOT” BUT WHO ARE NOT LISTED AS ONE OF OUR MEMBERS ARE USING THE FRUITS OF OUR LABORS ILLEGALLY and possibly providing and inferior service by deceiving patients.

    Certified Members of the Priapus Shot® Provider Group (click)<–
    Research Listings for the Priapus Shot® Protocol for Treating Peyronie’s Disease (click to read)<–

    Best regards,

    Charles Runels, MD

     

    Inventor of the Priapus Shot® Procedure

     

  • Walking to Your Best Penis

    Dr. Runels Explains How Walking Can Improve Your Penis & Your Life

    Since sex can ask for the heart about as much as walking up stairs, man is good in bed for about as long as he can comfortably walk up stairs.  Is that enough to encourage you to think about walking?

    Ask your physician before following any advice on this podcast…

    Priapus Shot® Providers<–
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    Resources Mentioned…

    4-Color Pens (these make people happy:)
    Airpods for iPhone

    Audible.com<–

    iPhone 7

     The Great Courses (click)<–

    Transcription

    Let’s talk about walking. Now, why is walking so important and other forms of aerobic exercise are important, but why do I prefer walking over those other forms of exercise? I’m a big fan of swimming. The problem with swimming is that it requires a swimming pool. If you don’t have an indoor pool, then the weather must be proper and it’s expensive to maintain this. Usually if you’re using a YMCA pool or something like that, access to the pool is a problem.

    The problem with biking is that it’s been shown that long-term use of the bicycle seat can cause erection problems because you’re sitting on the pudendal nerve. You can have numbness and it can cause erectile dysfunction. It’s not just one study but multiple studies showing this to be a risk. Of course you could have a properly seated or fitted bicycle seat that might help with that but, again, you’re also limited to you need your gear and there’s some risk involved with actually being on the street. It seems like there’s a person killed about every third year in the town where I live where there’s a lot of biking that goes on. I used to do triathlons. The culture of the triathlon crowd was that it wasn’t if you’re going to crash, it’s when you crash your bike, how badly would you be injured? It’s just a part of the risk that you have from using a bicycle everyday.

    Part of the reasons that I prefer walking over other aerobic exercises is that it’s safe. You don’t need much gear. You can do it anywhere and it seems to be very, very, very effective. Now, walking does much more than just “increase your circulation.” It’s the best. It’s probably the best, at least in the top three best habits that I could tell you to do. Here I mean this is a keystone, cornerstone habit. For example, what do I mean by cornerstone habit? Let’s say that I tell you it’s a good thing to have an apple a day. Well, one apple a day is a good thing. It’s an appetite suppressant for more caloric, calorie-dense foods that may not be so helpful. An apple has some nutrients that are useful to you.

    But one apple a day does nothing, relatively nothing, in comparison to walking a certain number of miles per day, which we’ll get to. Walking does so many other things because it changes other things in your secondarily. So, for example, keystone bad habits might be smoking. Smoking does so many harmful things that it’s really a cornerstone bad habit. So this is the thing that I see most consistently. It’s the thing that I see most consistently in men who function sexually into their eighties with normal sexual function without any medications, and it’s the thing that I see most consistently in people who just maintain clear thinking and productivity and excellent health into their seventies and eighties. And of course, it’s not just about maintaining this excellent health into your eighties, it’s the fact that this same cornerstone habit gives you improved health in your forties and fifties.

    I’m a big fan of George Sheehan, who wrote prolifically. He’s a cardiologist who wrote prolifically for Runner’s World when other cardiologists were saying that walking and jogging would create this athletic left ventricle hypertrophy, and it was a bad thing to do. And now we know of course that is not true, and that walking is a very good thing to do. We’ll get to why that is so very shortly. But George Sheehan always said “You know, even if walking or jogging does not improve or extend the length of my life, being out on the street everyday, doing the miles improves the quality of my life today.”

    You know, one of the ways I like to think about health is what I call the Titanic philosophy. If you’re on the Titanic would this be a habit that you would do everyday while you’re on the Titanic? Suddenly you wake up, you’re on the Titanic and you think “Hm. There’s a good possibility I will be gone in this very cold, very frigid water within a week.” What would be the habit?

    I would still do miles because I’m going to show you how these miles add to the life of that day, but I don’t think that I would overdo it and be a marathoner that day because then it would take to much out of my day for the other things that I want to do. But I would still do the number of miles that I’m going to tell you because I would do things during those mile that would make me happier, and there would be things that happened during the day after those miles that would make my day better.

    So walking is extremely, extremely important. And let’s talk about some of the more specific reasons about why I’m saying all these things and going on and on about walking. There’s research showing that it helps with depression, that it helps with your bone density. It helps with so many things, so here’s some more specifics. One study showed that in women, their ability to orgasm improved for the first hour after aerobic exercise. Think about that. This is like an aphrodisiac, orgasm enhancer. Suppose you had a pill that did that. What would that sell for? But here’s something that’s free if you just go walking with your lover, take your wife with you. And then you have sex when you come home. It’s a free aphrodisiac that’s been proven to increase her ability to have an orgasm.

    Next reason. It does actually do more for your heart and your circulation than any pill. Now we’ve talked already about how your erection is basically a water balloon that’s filled with the waters, metaphorically, the water is blood, and the ability to blow up the balloon depends upon your ability to pump blood into the balloon and the integrity of the blood vessels so that the veins are not leaking and the arteries are open, so the veins have to close off, so that there’s no blood flow out of the balloon, and the arteries have to be able to pump enough pressure into the penis to blow it up. And the extent of the hardness and the size of the penis is going to be determined by that pressure.

    So let’s suppose that you had something that’s been proven to improve your blood flow and improve your heart better than any other pill on the market. Better than diabetes pills, blood pressure pills. What would that be worth to you? What I’m saying to you is that walking is that magic bullet, and it was actually used, that exact phrase was used. “This is the closest thing we have to a magic bullet” in the New England Journal in reference to walking, but the walking has to be to a certain extent, so another research project, and we’re getting to what that needs to be shortly, but, another research project showed that the greatest predictor of whether you’re going to have heart attack within the next year is not even whether you smoke.

    The greatest predictor is whether you’ve had a previous heart attack. That puts you at high risk, but the second greatest predictor, even if you’ve had a previous heart attack. The next best thing, the next best predictor of whether you will have a heart attack this year, and of course, that … but whether you’re going to have a heart attack is an overall guide to how healthy is your heart. The greatest predictor is your anerobic threshold, meaning what’s your aerobic fitness level. Anerobic threshold has to be measured with a mass spectrometer, or it can be calculated. The most direct measurement is you breathe into a mask while you’re walking and then you extend your intensity or you increase your intensity while you’re walking and then jogging until your body has to swap from aerobic to anerobic metabolism. So the amount of oxygen you’re burning exceeds the amount that you’re able to pull in and supply. So that involves everything from the function of your lungs to the pumping ability of your heart. All the way down to the mitochondria within the muscle cells and how they’re able to metabolize the oxygen.

    You can actually measure the number of mitochondria, and within a week or so of starting an aerobic program of walking, you can see an increase in the number of mitochondria per muscle cell. And very elite athletes have a high number of mitochondria, so that makes them more efficient at burning oxygen.

    So that is the number one predictor, second only to a previous heart attack. The problem is, and the reason it’s not talked about by your physician is there’s no drug to sell. There’s no beautiful drug rep that comes into your doctor’s office and say “Hey, you should prescribe walking because it’s the best thing on the market for preventing heart attack” and improving erectile function and all the other things we’re going to get to about mental state and such. And there’s no ads on TV to tell you that. There’s no one teaching you that because there’s no money to be made. That’s not necessarily a bad thing, but it’s a thing, and it’s the reason your doctor doesn’t talk about it so much, or maybe yours does if you have a more progressive thinking physician.

    So, I want you to think very deeply about that. What I just told you is that even if you smoke, if you have a high aerobic capacity, you’re at less risk of a heart attack than if you don’t smoke and your aerobically out of shape. Next reason for walking, hormones. You get this whole change in metabolism that comes from your hormones. It’s not just about pumping blood around your body or even about increasing your aerobic capacity. Some things happen, your thyroid functions in a different way, in a more efficient way. You make some hormones that decrease your appetite for sweets, what you want to eat changes. The amount you want to eat changes. It’s a free appetite suppressant that, rather than putting your heart at risk for a heart attack as some appetite suppressants do, walking actually improves your heart and decreases your appetite for about two hours afterwards.

    This is another reason why I prefer aerobic exercise as opposed to say biking. When I did biking, when I did bike races and triathlons, and the reason I use the past tense is the risk of crashing, I just saw so many serious crashes. I decided it wasn’t worth it. And noticed that my penis would go numb sometimes after biking a long way. That didn’t seem to me to be a healthy thing, so before I ever read the research about this being associated with erectile dysfunction, it just made sense to me that anything that put my penis to sleep like your arm goes to sleep or your hand goes to sleep when you sleep a crooked way, in the same way, I thought, wow, something puts my penis to sleep doesn’t seem to be a good idea, so that’s why I keep using the past tense. I don’t bike anymore.

    But, when I did I noticed my appetite went up. When I lift weights heavily, there’s a little bit of a decreased appetite immediately afterwards, but my overall appetite can become more ferocious, which again if I’m trying to build strength or I’m trying to build the size of my thigh muscles so I can be an Olympic biker, then maybe that’s not such a bad thing, but when I’m trying to maintain a lean body and a healthy aerobic capacity, then perhaps a decrease in appetite, especially for unhealthy foods, is a good thing and that’s exactly what happens, what’s been proven to happen after aerobic exercise.

    The other part, and I can … this is part is maybe you’re going to call science fiction, but it’s real, is that there’s over two hundred hormones made by the pituitary gland. And the possibilities of what might be going on that we don’t the exact mechanism for but we see the effects of are really extremely exciting. What happens with those two hundred plus hormones with aerobic capacity we’re not sure of, but we know that some of the things that happen with thinking are not just with the body habitus or the shape of the body and the function of it, but the way the thought processes go are extremely, extremely exciting.

    For example, and let’s talk about that thinking now. If you look at the people who are walkers, Harry Truman always wanted the reporters to go walking with him to talk with him. Steve Jobs is well known for the fact that he preferred to do meetings while walking in his per usual uniform at work was walking shoes. Charles Dickens wrote in the morning and then he walked and walked and walked for many hours around London even into the evening, late even hours, was a very robust walker. When you look at the prophets, Gandhi walked and he walked, he walked across India. Jesus, you read stories of him walking on the road to Damascus and walking from city to city, and if you look at the miles that he walked, he was a walker. And Beethoven, he composed in the morning and in the afternoon, he walked for hours and hours and hours through nature and took little slips of paper with him where he would listen to nature for sounds and rhythms and then stop and compose while he was walking.

    Thomas Jefferson, brilliant statesman, wrote, you know, he was one of the founders of our, basically a revolutionary, we think our founding forefathers, but it’s nice to stop and think about, hey these guys were risking their lives to basically tell the king to kiss off. These were smart guys but they were also bad asses, and Thomas Jefferson thought anything less than two hours of exercise per day put you at risk and made him less thoughtful.

    Also, walking has been shown to decrease inflammation. There was this time that we thought people with arthritis should not move, but now we know that actually movement decreases the inflammation in people with rheumatoid arthritis, forms of inflammation. And of course, we are talking about the penis, and walking has been shown, it’s almost cliché now, I don’t know why we even need any more studies to show it. It’s been shown over and over and over again that aerobic exercise improves the erection usually by about five on that five to twenty-five scale.

    Now why would you not want to walk? There are some legitimate, there are legitimate reasons for not going walking. First it does take some time, and I don’t know many people who feel like they have extra time. Most people between their work and their hobbies and their avocation and their vocation and their family and their spouse, their children and their friends, their clubs, their associations, their … all these things that are pulling at them, they feel pressed for time. Part of the reason that Americans are probably sleep deprived, well no “probably”. We are sleep deprived, most of us … is that there’s this urge to do more, do more, do more, and so to ask someone to do the amount of walking that I think makes people healthy, if it takes away from your time, you’re not going to do it.

    But of course, I’m going, if you follow my plan, you’re going to have more time in your day if you do walking the way I show you how to do it. So I’ll take that reason away from you, if you follow my plan.

    What about the fact you have to go outside to do it. If you live in an area where’s too hot or it’s raining, in my area sometimes there’s lightning, there’s a lot of rain, we have the most inches of rain where I presently live of anywhere in the United States. Not the most days, but the most inches, and huge amounts of lightning. You may live where it’s cold. You may live where there’s traffic or crime, so getting out of your safety zone of your office or your house could be a problem, and then there’s of course injury. Are we going to wear out our joints or twist an ankle or be hurt by a car, or mugged or shot or robbed. These are things that are legitimate concerns.

    As far as the physical injury, there’s this logarithmic curve where, if you look at the injury rate, there’s almost nothing, if you’re at home, of course you could fall off the couch or something, but generally speaking you’re unlikely to be injured if you just don’t walk at all. But if you look at the injury rate, it stays near zero until you pass about twenty-five miles per week. Once you pass the twenty-five mile a week mark, the injury rate goes up. When was in a marathon club, everybody had a little nagging something that was bothering them. Eventually I developed some heel spurs and people just get stuff when you start running twenty miles a day or you’re doing eighty miles a week, a hundred miles a week. You start to have injuries. So I think that you should keep your range in a particular range, and particularly under the twenty-five mile mark to avoid those injuries.

    So let’s plunge into the way I think you should, can walk in order to avoid these problems. First of all, as far as the way to make sure you do the miles, I recommend that you do an out and back course. If you walk in a circle, it’s too easy to stop. If you walk on a treadmill, it’s too easy to just stop and get off the treadmill, and so there are times when you need to do that because of the weather and traffic and such, but as a general rule I recommend that you walk outside of your door, your hotel or your mother’s house, wherever you happen to be that day. And you walk half the distance you intend to walk and then you turn around and you walk home.

    Now you can split it up so if you’re goal is to walk five miles a day, you walk two miles this morning and three miles in the evening, and so you walk a mile out, turn around and walk back, and you’ve done two miles. Or you could walk two and a half miles out and turn around and come back and you’ve walked five miles.

    You realize that, when I say Cortez, that’s the guy who came here, the conquistador who came here and his … to the states and his men were about to rebel and wanted to go home, and he just took that option away by burning the ships. Then his men knew they had to either win or they would be destroyed by the natives. So they fought ferociously because there was no retreat. So in that same way, if you’re walking laps, you can stop, but if you walk out and that’s usually the easiest part of your walk is when you are starting, and then you have to come home unless you call someone to come pick you up. You have to walk home, so that helps us with the psychology.

    Another thing is what I call my “ten minute rule.” When you’re ready to walk, never decide to not walk sitting on your booty. Get up, walk for ten minutes, and after ten minutes if you still feel like you don’t want to walk, you can stop. But make that decision after walking ten minutes, and you’ll discover that you’ll have some of your most wonderful walks after you do that. After you think that you don’t want to walk, but then you go ten minutes, you think “Hey, I feel pretty good” and then you want to keep going. So you just keep going. So do follow the ten minute rule.

    So how far should you walk? I recommend that you make a goal of twenty-one to twenty-five miles a week. And I prefer a weekly goal because you might have days when you’re busy and you can’t walk at all. Or maybe you have a rest day because of your convictions with your religion, you prefer to rest on Saturday or Sunday and not do anything. That’s fine. It’s a good thing. So take that day off and don’t walk at all. But if you make up for it, so if you’re only going to walk five days, I prefer a twenty-one to twenty-five mile week. That gets you into the range of health, and that range has been show to decrease your overall mortality in half. It cuts it in half. So over the course of the coming year, it’s been proven all cause, I mean it’s getting shot by a thief, crashing your car, all cause mortality. I think this reflects the fact that it changes behavior. It changes what you do and where you go because how else can you account that there’s even less trauma who walk to this amount.

    But it doesn’t happen with ten minutes a day or three miles a week, it starts to happen when you approach the twenty mile per week mark. So twenty-one to twenty-five miles per weeks, that could be three miles seven days a week, it could be five miles five days a week, it could be two miles today and five miles tomorrow, and six miles the day after that and one mile the day after that, but I would set a weekly pattern so if you intend to rest on Saturday and not walk at all, and Monday’s a busy day, maybe you walk five miles on Sunday, and one mile on Monday, and four miles on Tuesday … you get the point, but you decide how many miles you’re going to walk each day and you keep that pattern.

    I have found that that pattern changes for me depending on what’s going on in my life. When I was a medical, when I was in my training as a resident, I trained for a marathon by running thirteen mile twice a week. Thirteen miles twice a week because I two days when I could be out of the hospital and fairly rested, but then the other days I was in the hospital often working all night, unrested, unable to go outside because of my duties within the hospital, so that was what I had, I had two days. So those two days went thirteen miles. For a total of twenty-six miles a week.

    So I prefer that you spread it out more than that. Actually it’s been shown that you do better even doing two episodes. Doing a walking session twice a day so you would have, you could have ten walking sessions per week. So I don’t want to beat this to death, but those are the principles I would follow. And then, very, very importantly, keep a record. It’s been shown over and over again, if you want to change the behavior, one of the most powerful things you can do is just start keeping a record of it. Keep a daily record, keep a weekly record. I prefer that it be actually on a piece of paper, although you can use your computer or your phone to record it while you’re doing it.

    I like it to be out of my computer where I can look at it, in a notebook or on the wall somewhere. But I can’t stress the importance of this enough. As a matter of fact, I will almost guarantee that you will not be successful with your walking program if you’re not keeping a record. It’s been shown over and over and over again in research that people over-estimate the amount of exercise they do and the under-estimate the number of calories they eat. You just can’t, some things we are just too biased to be accurate recorder, estimates of, and these are two of those things. So you will lie to yourself and as Shakespeare and many proverbs have said, we tend to lie to ourselves. So keep a record. Let me say it again, keep a record.

    Okay. So another thing. Bring a few, as far as comfort along the way, don’t make a big deal out of it. Bring a few bucks in your pocket if you want to stop and buy a bottle of water while you’re walking, if you want to stop in the park. If you have a turn around point that involves a park bench or a rock that you want to sit on in the forest. Stop and sit on it. I don’t want you to get hung up on how fast you’re going. I want you to think about the distance. I want you to think about the distance. That seems to be the most important.

    So, I want to stress this also. If you get hung up on your pulse rate, you will probably stop doing this. Imagine that I told you the most healthy thing you could do on the planet, would be go get a massage for an hour, seven days a week. Giving up that hour, I would actually have more trouble with that than walking because sitting there is a zombie state where I’m either meditating to a different level of consciousness, I’m not reading, I’m not learning, not doing all the other things you’re going to learn how to do when you’re walking, I’m just basically losing that hour for some benefit from the massage but probably more benefit, there’s a decline in the amount once you pass a certain state. There obviously are some benefits from massage. I don’t want to take away from that.

    But too much of it, where I’m giving up my life, I’m back to the Titanic principle. So, I would quit doing it. The point being that even for something pleasurable, you can’t do it, you won’t do it consistently. Even if it’s pleasant, if it’s pulling from your life. So how can you expect to do walking consistently if you make it unpleasant. If you make it ferocious. Now you will reach a point to where you sometimes want to touch into the pain zone, maybe you want to do what’s called the Fartlek System where you get your heart rate up by walking or jogging or sprinting depending on your level of fitness and the health of your joints, and then you slow down, you go fast and you go slow.

    That’s good, and maybe you have a time when you want to train. You’re young enough, you’re training as an elite athlete, and it’s a different level of fitness. But if you’re in this for the long haul to be healthy and you say to yourself “This walk is worthless unless I reach a certain level of pulse or discomfort” then you’ll stop doing it. As far as the calories go, it’s a physics problem. If you tell me you went walking for thirty minutes, that tells me nothing. You could walk a foot and stop and you could take a thirty minutes of being, a little bit over exaggerating here, but you could sure take thirty minutes to walk across a room, just move a foot, one of your feet every inch or so.

    And you would be honest to say that you walked for thirty minutes. But if you tell me you took a body, a mass that weighs 50 kilograms and you move it a mile or a meter, then you can calculate that. It’s mass times distance and that’s foot/pounds. So if I take a hundred and ninety pound man and I move him 5,280 feet, then I’ve moved him 190 pounds times 5,280 feet and that you get the number of foot pounds. That are the work that, of a hundred and ninety pound man uses to move his body a mile. So when you look at calories per mile on the charts, what they’re doing is assuming a twenty minute walk or a ten minute jog which … and then there’s extrapolating from that the number of calories. They don’t actually know to get the exact number of calories you would use, the weight times the distance and you would have a finagle factor based on the amount of heat produced.

    You only have about ten percent more calories if you’re jogging versus walking. , So listen to that again. If I walk a mile, I’m going to burn the same number of calories almost as if I jog a mile, I’ll just take twice as long to do it. And they’ll be about ten percent more, that’s it, if I do the jog versus the walk. So now knowing that, if you, as far as the calories go with the weight loss or the maintenance of weight, it doesn’t really matter whether you walk or jog it. What George Sheehan used to say was “Go at a speed that you’re able to talk comfortably. If you went a little bit faster you would be unable to talk comfortably.” So if you’re having to … stop … in the middle … of a sentence … like that when you’re jogging then you may be getting into an anerobic range and that’s not a bad thing, you can do that periodically by speeding up your walk or your jog, but it’s not necessary to do that the whole distance where somehow you’ve wasted your time. Which unfortunately some health people, physicians/personal trainers teach people, and I think that’s not a smart thing to do.

    So you’re going to walk at a speed that’s comfortable, where, and if you want you can reach to a place where you’re able to speak easily but faster might make it less easy, and you’re going to record the distance. I wouldn’t worry so much about the time. Just record the distance. And you’re going … most people are going to take about twenty minutes for a mile or about an hour to walk three miles. So think about that for a second. If you’re going to commit to twenty-one miles a week, you’re committing to an hour, and average of one hour out of your day, seven days a week, that’s a big commitment.

    Which brings us to the next part of this, which is when will you do it? And what can you do during that time so that you’re not actually losing time, but gaining time. So as far as the “when” I recommend when you first wake in the morning, during which time you can do your affirmations, you know, some of the other things we’ll talk about later. The affirmations are great first thing in the morning or prayers. Visualizations. Those three things go very well, even while walking, although you can do them while meditating, or sitting as well, but walking, affirmations are great when walking.

    If you have a job that confines you and you have less freedom, you have to work strict brackets of time so you come in at eight and you work until noon and then you have an hour for lunch and then you have to start back at one, you will have a much healthier day if you walk during that lunch time and your lunch becomes a protein shake or something you can eat easily within fifteen minutes. I love protein shakes because you can drink them. You know exactly how many calories there in there. You can put fruit in there so you can have a couple of servings of fruit and some protein and you can consume it in five minutes and use the other fifty-five minutes for you walking.

    Immediately after work is great, either, I prefer either before you leave work, so you put on your walking shoes and you walk at work, or you walk out the door. You walk and come back, you drive home, or you stop on the way home at the YMCA or somewhere, a park, or the forest, and you walk and then you complete your drive home. It’s really, really difficult when you come home and there’s family and they want to … then immediately put on shoes and walk out the door, unless which is the next option, you may want to come home, and put on your shoes, and you walk with your spouse or your children and then you come home and you have dinner.

    If you wait for the walk after dinner, it can sometimes become very, very difficult to have the energy. It’s just too tempting to stay. So this is my least favorite time to go walking, immediately after dinner. I tend to get lazy and want to do other things. Right before bed, it’s a really nice time to walk, although this is time for more leisurely walk, or the increase in heart rate can cause you to have trouble sleeping.

    Now, as far as walking with other people, this brings me to another thing. It’s very seldom that people want to walk at the same speed. So what do you do with that? I prefer to let the slower person set the pace or else you’re going to interfere with the slower person’s desire to walk. And with children, I let them walk ahead of me. If I’m with someone who’s somehow not as fit or bothered by something, joints or something, I let them set the pace. Another wonderful thing to do, thought, if you’re walking with children, and as a single father, with my children with me most nights of the day before they left the house, most nights of the week before they left, grew up and left, I had the ways of doing this.

    One is that you walk back and forth in front of your house, so if you walk … if you have a quarter mile marked off such that your house is in the middle of the quarter mile street, so a block is a tenth of a mile, so it’s about, let’s say, two blocks. A distance with your house in the middle of it, then you walk a block one way, you come by, you pass your house, you walk a block the other way, you just walked two tenths of a mile. The you back past your house and the point is that every time you pass your house, your checking the house isn’t burning down, kids are in the front yard and behind the fence, everybody’s happy, you actually never lose sight of the house if you’re never more than a block away.

    And you can back and forth again, I’m not a big fan of doing laps but that can be a way to do it, if it’s necessary because of children. I lived at a place once out in a rural spot where my drive way was two tenths of a mile so I could walk out to mailbox and come back and that was almost a half a mile. My children could be out in the front yard playing around the house and I never lost sight of them. Everything was wonderful.

    Another great way, I love this next way, to do your walking if you have small children is get to a school somewhere and then you put the children out in the middle of the football field and you walk around them. So they’re out there with a ball or even in a playpen if they’re that young, and you never lose sight of them, they’re in the fresh air. They’re having fun and you get to walk around them. Again it’s a lap system, so it’s not ideal, but sill pleasant and most high schools or YMCAs … the high schools, of course if they’re having a football game you can’t do that, but it’s a way to do that. On the weekends or during the off season when their track is available. They usually like that especially if you have children going to that school.

    Another thing that I like is when you’re at a sporting event. Let’s say your children are practicing football or baseball or soccer, whatever their sport, you can walk around the field so instead of sitting there with the other parents, which of course, you need to do occasionally to be sociable and those connections that are so useful between parents. Instead of doing that, you can walk around the field and still see everything that’s happening, and it’s wonderful. So that’s a great thing to do.

    I sometimes even do that during the event, which is maybe a little bit disrespectful in the eyes of some people because it looks like you’re not paying attention. But of course you’re paying attention. You’re more alert and you can cheer as well as anyone, you’re just seeing … you happen to go to the enemies’ side because you go to the opponents side of the field if you make a complete lap. But I have done that, although I do that less often during events. It’s more appropriate I think during practice.

    Other things you can do to help your walks … we just got through talking about how to walk and make it appropriate with your family. But what about just getting things done. What are some things you can do so that the walk doesn’t take from your day, it adds to your day. Remember I said that I promised you that if you … I’m going to show you how to make the walk not take time out of your day, but give time to your time. It’s counterintuitive.

    One thing you can do is make phone calls. You know how Steve Jobs did his meetings while walking? Well, how much time are you on the telephone? In most work places, it can be more than hour per day on the telephone. You’ll be more alert. It’s wonderful the technology we have. Right now, I’m using the air buds that come with an iPhone. So they’re not getting tangles up with the cords. The sound is wonderful and I can have a conversation unless the traffic is really, really loud, and in that case, I use some Bose noise canceling earplugs that connect with a wire. It’s a combination. It seals the air, so it’s like wearing ear plugs and it counteracts the noise so you’re able to hear very well.

    My preference is to never be in traffic, that that’s loud, that is that loud, and so the air buds are how I prefer to make my phone calls. I’m more alert, especially if it’s a call that’s going to be difficult for me emotionally, I have to deliver bad news or have a conversation, say with my attorney about something that’s not pleasant. There’s always battles to be … we all have battles. We have battles with the forces that want to kick over our sand castles. You know, I live near the beach, and it’s interesting. You can build a sand castle and then sit there in a chair and watch. And most people walk by and admire the castle, and ninety-nine out of a hundred people walk by without admiring it, they’ll walk around it …

    But then you’ll get that one out of a hundred who will come by and take pleasure in kicking over your sand castle. And those people are there. They’re out there. And so we have out battles, we have the, just this thermodynamic force that says things go to a place of less organization. And if you want things to be organized with your business, with your personal life, with your spiritual life, you will fight battles. And for those conversations that require you’re warrior state, walking is … makes you more alert and it makes you a better warrior, so that’s when you make those phone calls.

    Next thing. What if I told you that I could give you the equivalent of weeks of free time in class. Let’s calculate this. If you did an hour walking per day, and during that time you’re listening to books, that’s one hour times three hundred sixty-five days. That’s close to four hundred hours. So to make the math easy let’s say four hundred hours, and let’s say that you have a forty hour work week, four hundred divided by forty is ten weeks. That’s two and half months of full time, forty an hour per week, class. And when I was in college, I was not in class forty hours, but if you counted class plus studying then that was forty hours, sometimes more.

    But so now that you basically … what I’m telling you is this. If you listen to a book, every time you go walking that’s equivalent to a full time class for two and half months out of your year. What could you learn with that? I know a Dad became a very successful investor and retired in his early fifties on his investments, and most of his learning about investments involved listening back then to cassette tapes. There was no … the options were much less. There were no … there was no iPhone. It was a cassette tape player to listen to. So listening to books is amazing what you can do.

    Suppose I told you that you could go walking with Aristotle. You could go walking with Warren Buffet to learn about investing. You could go walking with spiritual leaders. You go walking and listen to St. Paul read his letters to you. You could walking and listen to the professors from the Ivy League colleges. It’s amazing. That’s exactly what you can do with a pair of earbuds and iPhone. So, would that add to your life? Would that make the rest of your life easier? And the other wonderful thing about this is I will promise you that you will, and that’s my iPhone telling me something now, but I promise you that you will, you absolutely will retain more. You’re going to learn more, you’re going to have ideas that occur to you more if you’re walking and listening to this.

    What do you do if you have … if you suddenly have a problem that you just have to solve. It’s life or death. You have to figure this out. Do you sit at your desk? Intuitively, without thinking about it, without me telling you to do anything, you’re going to get up and pace the room. And it’s not just burning up energy, you’re thinking better on your feet. I love something George Sheehan said. He said “I never trust an idea that I get while I’m sitting on my bottom.”

    Think about that. I’m not saying you don’t get ideas sitting. You might get amazing ideas sitting and meditating, but don’t trust it until you go walking and think about it.

    So next thing I want you to think about is that don’t just think about the books. You can pose yourself a problem and say “Okay. I’m going to walk and think about this problem while I’m walking.” And my favorite way to do that, because when you’re … is to take note cards. Take a three by five index cards, two or three of them. Stick them in my pocket with a cheap pen hat doesn’t matter if I drop it or I lose it, it gets wet in the rain when I’m walking. And then say “What I want to figure out” and then instead of pacing your office, this is going to be theme of this walk. To figure out how I should deal with this problem with my child. To figure out a new way to market this particular product in my office. And then you go walking.

    If you want you can listen to a book that relates to that while you’re walking, but you could also just listen to what’s inside of you, what the piece of God that’s inside of you, or the piece of you that’s inside of God, however you want to think about that. And sometimes it’s better to leave the phone off is what I’m saying and bring a pen and an index card in your pocket.

    Just a safety thing I would say is that when you are walking with your phone, stop when it’s time to fiddle with the phone so that you don’t step in a hole or step in front of a car. Just stop walking, it’s okay. Remember I told you it’s more about the distance than your heart rate? I used to think when I was a teenager running track that if I was going to run five miles, if I stopped to tie my shoe, the five miles didn’t count. You just had to run it start to finish without stopping. But I grew up. Don’t worry about it if you need to stop. Just stop and fiddle with your phone, pull up the book, dial the phone, then after you dial the phone and you’re talking, now throw your phone in your pocket and walk and talk.

    Now we mentioned this previously but another wonderful thing to do while your walking is to have meetings. You know, we talked about how Steve Jobs preferred to have his meetings that way, especially if you have a meeting that’s going to be emotional. It really helps if you’re walking and talking. Even a creative meeting, you bring paper with you or you stop and you make audible notes or recordings on your phone, and you and the person you want to meet with go walking, or persons. It gets to be a little bit more cumbersome if it’s more than three people. Two people. I think it’s ideal for a walking meeting. But you can do it with more. Once you get more than about three or four people, though, it becomes more awkward because it gets hard to hear. But it’s a great way to have a meeting.

    Now let’s talk some about gear. I will tell you my preference, and my personal preference for my feet .. I have high arches … is High Balance. If your feet, it may be a different type of shoe. But I do recommend that you not skimp on the shoes. Find yourself some good shoes. Part of what threw my feet off is I decided it wasn’t most … it wasn’t difficult enough to do my ten mile runs in shoes. I had to do them in boots, and if goofed up my feet. You need well fitting shoes, and I recommend that you go to a real shoe store. There’s a subculture of people who just love to run, but they don’t just love to run, they love shoes. And they study them. These days they even have computers that analyze your feet if you stand on something, and these people study shoes. They love making your feet happy.

    You can go see a podiatrist and have them think about your feet. If you have feet problems and they’re able to make inserts for your feet. They can make you whole, all the way up your spine happier. It’s amazing what the proper shoes can do for you. But unless you have a problem with your feet. I think it’s sufficient to go to a good running store. And when you walk in the store, id there’s … if it’s an assembly line, and that person you’re talking to is chewing bubblegum and they look like they’ve just started working there yesterday, find another person to help you or another store.

    Persons who … when you walk in you should see somebody who loos like they’re a runner, and they should know … they should want to talk to you about the shoes because they love them so much. You’ll know you’re in the right place.

    As far as clothing goes, I used to make a big deal out of what I wore and in the cold weather it was one thing and hot weather … you know, don’t sweat it too much. The more difficult you make it to get out the door, the more likely you are to not go walking. These days I just throw on my walking shoes. I’ll go walking in my suit. I’ll go walking with a tie. I don’t make a big deal out of it. Usually all I have … I prefer, though, a pair of jeans and a comfortable shirt and my New Balance shoes. I gran my iPhone with my air buds and I’m ready to go. I might grab an index card and a pen.

    I like the old school, four color Bic pens. I just still like that it’s they’re great for note taking. If I lose it, I actually like to lose them because that way somebody finds a pen that writes in four colors. It makes me happy. So I have a four color Bic pen I throw in my pocket with an index card. And I like to get the index cards that have my name and address printed on them that I get from a stationery store, so it’s … if I make notes on it and hand it to somebody, they have my contact information. So that’s all I need.

    I might grab a hat if it’s cold or gloves. If it’s raining I don’t worry about it. I just leave the iPhone at home and go walking or I put it in a plastic bag in my pocket. But lightning keeps me home. If it’s too icy where I’m going to fall and break something, I stay home. And when I stay home, I mean, I go walking on an elliptical trainer or a treadmill. I have a gym that’s close to me that’s twenty-four hours. I prefer a twenty four hour gym that’s available so it matches my schedule. You may not have something like that available. If you don’t, then I recommend that you by yourself an elliptical trainer or a treadmill.

    I like ellipticals because they don’t put a strain on your joints. But have those for your bad weather times. I prefer to go outside. There’s something about the outside that’s really good for you, I think. But you may live in a place where the crime’s too bad or the traffic’s too bad. If you’re having to stop and just wait so much that it’s a nuisance because there’s so much traffic, then get to a place where there’s an elliptical trainer and do everything else the same. You can listen to the books, you can make the phone calls, and if you keep the pace at a comfortable pace, you’ll still be able to do your training and not jump off before you’re done.

    Adjust the tension or if it’s too hard because … and you feel more like you’re lifting weights or pedaling up hill on a bicycle, then you’re elliptical trainer is either the wrong machine or the settings are off. Make it to where it feels about like you would feel if you were walking up a one percent grade or on flat land. If you’re on a treadmill, that’s usually about a five percent grade. If you’re on elliptical, you just have to fiddle with the setting on the tension to where it feels about like what you would feel if you were walking on flat land.

    If you want you could use a Garmin watch or an iWatch to help you with your keeping track of things. I think that’s useful and fun and it helps you with your record keeping. I have a walking app on my phone that I’ll put the link to. All the links to all this will be beneath the podcast. Everything that I’ve talked about, so I have an app that’s wonderful. It keeps track of everything, and I even have it send an email to my EverNote account so there’s a record of where I went that day and what the weather was like. And it’s nice to have maps of where I’ve walked, whether I’m visiting family or happen to be on a business trip.

    So those are my tips for walking and I hope what you’ve seen is it’s amazing. I just told you how to get almost three months of full time class and remember it better than if you were sitting in a classroom with the great thinkers of the world. I’ve told you how to do meetings in a way that Steve Jobs have done it. And how to do creative work in the way that Beethoven and Charles Dickens did it. And the way revolutionaries like Thomas Jefferson thought about overthrowing a fricking King. And these were walker people. And I’ve also told you how, as a side effect, you’re going to have a healthier penis that’s straighter. You’re going to have decreased inflammation if you have Peyronie’s. And it’s going to be harder because you’re going to able to pump blood into that thing because you’re heart’s going to be functioning better and you’re blood vessels are going to be more open to pumping blood.

    So there you go. I sure hope you find this useful. I hope you’ll stay in touch with me, subscribe to my emails. Join our group. See the doctors that I’ve trained and stay in touch and let me know how you do.

    Thank you very much.

    Peace & health,

    Charles Runels, MD

     
    Inventor of the Priapus Shot® Procedure

  • Straighter, Harder, Bigger. Step 3. Priapus Shot®

    Straighter, Harder, Bigger. Step 3. Priapus Shot®

    Priapus Shot® Procedure

    The Priapus Shot® procedure indicates a specific way of treating the penis with blood-derived growth factors extracted from the man’s own blood (autologous). Some people call these blood-derived growth factors platelet-rich plasma (PRP) but there may be growth factors in plasma we don’t yet know about that do not come from the platelets. The name “Priapus Shot®” is registered with the US Patent & Trademark office as a “service mark” to protect patients by indicating a specific protocol. The name is not a synonym for the injection of blood in to the penis—such a definition would not be specific enough to indicate any particular quality of care. and so would not warrant protection as intellectual property.

    The trademark defines a specific method of that providers agree to follow and develop; this agreement offers quality control and is followed and developed by over 500 urologists, interventional radiologists, family practitioners, and internists in multiple countries and by faculty in medical schools where further studies are being done.

    The Priapus Shot® procedure protocol also involves patient selection, patient evaluation & education (including explanation of consent), preparation of the PRP, local anesthesia, PRP injection, post injection use of a penis pump on a daily basis, and a daily dose of tadalafil (in come men). Other post injection steps can include: stopping smoking, CoQ10 (12), vitamin E (13), Trimix, and aerobic exercise. Protocol steps vary depending on the patient and those variations also comprise the Priapus Shot® protocol.

    Patient selection includes identifying those who may need hormonal treatment, or family counseling, or vascular surgery, as well as those who may have co-morbidities or who may be taking drugs that interfere with sexual function. Some patients are not treated with the Priapus Shot® protocol because another treatment or no treatment is more appropriate.

    The policy of most of our providers of the procedure offers a complete refund to any man who is not happy with the Priapus Shot® procedure.

    Consulting with the patient includes informing him that unexpected side effects could occur and the results will vary with some patients seeing no benefit. Antibiotics fail in 1 in 5 people in the hospital with pneumonia—resulting in death. Antibiotics “work” but do not work for all people. The same can be said for most all procedures including the Priapus Shot procedure.

    The preparation of the PRP involves a device approved by the FDA for isolating PRP from whole blood for autologous use. Since blood is not a drug, it is not governed by the FDA but the devices used to isolate PRP for injection back into the body are regulated by the FDA. Multiple kits have gained FDA approval. Some of the approved kits include Regen, Magellan, TruPRP, Eclipse, Pure Spin, Harvest, & Emcyte. There are over 8,000 research papers on pub med discussing the science of PRP, and not one serious side effect has been documented when FDA approved kits were used to prepare the PRP.

    Most men find the procedure very comfortable if a topical lidocaine cream is applied to the penis about 15 minutes prior to the procedure. A very small needle (1/2 inches long, 30 gauge) needle is used for the injection. However, some men do ask for a dorsal nerve block which can easily be done using 2% lidocaine for a near painless procedure (this same block can be used for prosthesis placement—so it makes a 30 gauge needle completely painless for most men.

    The Science

    An early report that PRP may be useful in the penis appeared in a paper published in Urology in 2003 mentioning that, in animal models, using blood-derived growth factors injected into the penis successfully treated erectile dysfunction and also mentioned that such a strategy may be feasible in men— actually providing a way to correct the underlying pathology (1). In contrast, Viagra and Trimix do not correct the underlying pathology of decreased penile circulation.

    Another animal study in 2010 showed that transferring adipocyte derived stem cells (ADSCs) into the penis caused endothelia cell growth (new blood flow) as well as increased nitric oxide activity in the dorsal nerve (harder erection). But, the ADSCs were tagged before injection (to keep up with them) and most of the injected stem cells died! So the improvement seen was not from maturation of the ADSCs but rather from recruitment and activation by growth factors of stem cells already in the body—indicating PRP may demonstrate a similar effect (2).

    Dr. Virag (also a pioneer of Trimix injections) published research demonstrating improvement in erectile function, size, and correction of Peyronie’s disease with the use of PRP. His studies both published (and to be published) demonstrate a mean increase of 7 on the ED Intensity Score when PRP is injected into the plaque and into the corpus cavernosum of the human penis (3).

    Find Certified Priapus Shot® Provider (click)<==

    One of the growth factors found in PRP (over 20 known) includes vascular endothelial growth factor (VEGF). In one animal study, the animals were castrated causing a shutting off of testosterone to create a penis that demonstrated, on microscopy, atrophy of smooth muscle and nerves as well as endothelial cell pathology. Then another group received VEGF injections directly into the corpus cavernosum along with castration. VEGF injection into the penis at the time of castration prevented the atrophy as effectively as did testosterone replacement. Moreover, VEGF reversed cavernosoetric findings of leakage (4).

    The above studies and others not cited indicate an improvement in the health, circulation, and strength (density) of penile tissue with injection of blood-derived growth factors into the penis.

    What Goes with the Shot?

    In regards to improvement in erection firmness, the Priapus Shot® protocol also includes a recommendation of aerobic exercise which by meta analysis of 5 randomized controlled studies using the Erectile Function Scale showed an increase of 5 (5,6).

    As previously stated, the complete Priapus Shot® protocol, also includes the use of a penis pump, which as a stand-alone therapy has been demonstrated to improve erection both as part of a penile rehabilitation program as well as an adjunct to other therapies (7,8).

    This same penis pump strategy, even without the PRP, has been demonstrated to increase penis size by 2-3 cm, while traction (another physical therapy that can be included as part of the Priapus Shot® protocol) was shown to increase penis length by 1.5-2.5 cm (8, 9). Adding PRP to the protocol shows improved results according to data collected by urologists currently utilizing the Priapus Shot® protocol (to be presented). The 2.5 cm improvement seen with the penis pump alone is in the 10-20% growth range for the average sized penis. As previously stated, while patient results vary, any patients that are not happy with the procedure are given a complete refund.

    Ultrasound studies of humans, post treatment, by Dr. Virag and by other physicians who offer the Priapus Shot® protocol demonstrate improved blood flow, an increase in endothelium (improved health), and decreased plaque size. Dr. Joseph Banno of Chicago recently presented a paper showing the Priapus Shot® procedure decreased venous leak as well as increased intra-penile arterial pressure.

    Dr. Virag’s studies, using the injection of PRP as a stand-alone (without physical therapies), also demonstrate improvement in the angle of the penis in men suffering with Peyronie’s disease (3). Also, strict adherence to a penis pump regimen is part of the Priapus Shot® protocol and the pump alone improves the angle significantly in over one-half of those studied in one study in the British Journal of Urology (10). This same study demonstrated growth of the penis using the pump alone (without the PRP injection). The PRP alone, in Dr Virag’s study, out-performed the pump with demonstration of remodeling of the plaque. I recommend using both methods: vacuum pump and Priapus Shot®.

    Studies show that the non-surgical treatment of Peyronie’s is most effective when a synergy of multiple modalities is engaged (11). So, the Priapus Shot® procedure includes the injection of PRP (demonstrated effective by Dr. Virag) combined with daily physical therapy using a penis pump for ten minutes twice a day and a daily low-dose of taladafil. Other modalities in the Priapus Shot® procedure that have been demonstrated to be synergistic include the following: stopping smoking, CoQ10 (12), vitamin E (13), trimix, and aerobic exercise. Such strategies are not intended to take the place of surgical correction or of the use of chemical surgery with collagenase—but rather to offer the man suffering with Peyronie’s disease the optimal non-surgical treatment as a first step with surgery reserved if non-surgical therapies fail.

    The penis pump alone (part of the Priapus Shot® protocol) has been shown to improve the effectiveness of Cialis and of Trimix injections (8). We are seeing men decrease the dosage of Viagra and/or Trimix by about 50 percent when the complete Priapus Shot® protocol is used. The Priapus Shot® protocol does not intend to make any particular therapy obsolete (including surgery) but rather to offer a protocol for enhancing an overall, synergistic approach to correcting penile pathology. However the surgical treatment of Peyronie’s disease can be unsatisfying and lead to serious complications (14); we (the Priapus Shot® providers) are seeing the safety profile of PRP and the Priapus Shot® protocol as offering an appealing conservative and often effective step to take before proceeding to surgery. The risk from PRP is certainly much less than for surgery and less than for collagenase—offering another reason to start with the Priapus Shot® when treating Peyronie’s or erectile dysfunction.

    Apply for Certification as Priapus Shot® Provider (click)<==

    When considering the duration of effectiveness of the Priapus Shot® procedure and risks involved, you may find it helpful to consider the nature of the cell biology employed. A review article considering the basic science of PRP discusses the fact that the autologous growth factors are exactly what’s generated to propagate healing should the man have surgery. The healing peptides, chemotactic factors, and pluripotent stem cells employed are exactly what’s generated by the normal healing process and offers no inherent risk for infection or allergy (16).

    In over 8,000 papers published about PRP on pub med, there is not one serious sequelae reported that I can identify (multiple review articles address safety). This seems logical when you consider the material being injected is autologous and normally produced to help healing and to fight infection.

    Wound care studies demonstrate the nature of multiple tissue types being regenerated (with no reported risk of neoplasia in multiple biopsy studies (17-20).

    Moreover, in rat studies (where biopsy of the dorsal nerve is feasible), PRP has been shown to help regenerate nerve tissue and restore erectile function when prostate surgery is modeled with crush injury to the dorsal nerve (21,22). Some studies of stem cell therapies demonstrate that the stem cells do not actually mature into healthy tissue but rather signal for the improvement of the involved ganglion and nerve conduction by recruitment of stem cells to the area – exactly what happens with PRP.

    Stem cells are not directly prepared as part of the Priapus Shot® procedure, but we are seeing similar results as what’s reported with stem cell studies. Stem Cell studies often use PRP as a carrier for the stem cells, bringing into question which is the active agent (23-24).

    The idea of safety is further emphasized by the literature indicating that not only are there no reports of serious allergic reactions to PRP, but research also shows that PRP can attenuate the autoimmune response. One split-scalp study (with placebo control) showed improvement in alopecia areata, with the use of PRP, that out-performed triamcinolone (25). Another study using PRP in the genitalia of women, showed improvement in lichen sclerosus as determined by both patient survey and by 2 blinded dermatopathologists (26). This attribute of PRP (attenuation of the autoimmune response) could partly explain the effectiveness of the Priapus Shot® protocol for the treatment of both Peyronie’s disease and erectile dysfunction since Peyronie’s is thought to be partly caused by an autoimmune response.

    Hard & Easy Cases

    Hard Cases

    • Penis Growth-Only 60% of men achieve 1/2 inches or more in growth (circumference and length). But, men in that 60% sometimes see up to 1.5 inches in circumference & length (often after 2 to 3 procedures).
    • Men with long-standing vascular disease see less response. If the blood flow going to the penis (ileac arteries) is blocked, then the Priapus Shot® injection into the penis will not help much. The man needs a vascular surgeon. One way to get an idea here….if the man sees absolutely no response when taking Viagra or Cialis for more than 2 years, then he may have blockages or other problems that the Priapus Shot will not help.

    Easy Cases

    • Post op for prostate surgery as part of a penile rehabilitation program. If the man could achieve erection before the surgery, the following the Priapus Shot® protocol could be very beneficial (even if it’s been 2 or 3 years since surgery).
    • Improved firmness of erection in the man who can already achieve erection. Typical results are that he may be able to cut the dose of Viagra or Trimix in half (but still need the drug) or if he needs only a low dose of the drugs he may be able to stop using them.
    • Improvement in lichen sclerosus. This is HUGE since lichen sclerosus appears on the foreskin with severe discomfort and often recurs even if the man has a circumcision.
    • Peyronie’s Disease. This possibility is another HUGE benefit of the procedure—with the Priapus Shot® probably safer and more effective than collagenase injections (research to be published soon). If a man undergoes surgery for Peyronie’s disease, the curvature often recurs later since the autoimmune process continues. Also, with surgery, there can be infection and shortening of the penis. None of those side effects have been seen with the Priapus Shot® procedure (side effects include INCREASE in size in most men with Peyronie’s).

    Summary

    In summary, multiple studies support the idea that blood-derived growth factors (when prepared in a proper way using a kit approved by the FDA for the preparation of PRP), as used in the Priapus Shot® protocol, support the health and function of the penis. Erectile dysfunction is associated with anhedonia, and successful treatment leads to better function, better relationships, and more pleasure in life (27).

    Hope you find this helpful!

    Peace & health,

    Charles Runels, MD
    Inventor of the Priapus Shot® Procedure

    Apply for Certification as Priapus Shot® Provider (click)<==

    Find Certified Priapus Shot® Provider (click)<==

    References

    1. Siroky M. Vasculogenic erectile dysfunction: newere therapeutic strategies. J Urol. 2003;170(2 Pt 2):S24-9.

    2. Garcia MM, Fandel TM, Lin G, Shindel AW, Banie L, LinC-S, and Lue TF. Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells. J Sex Med 2010;7:89–98

    3. Virag R. A New Treatment of Lapeyronie’s Disease by Local Injections of Plasma Rich Platelets (PRP) and Hyaluronic Acid. Preliminary Results. e-mémoires de l’Académie Nationale de Chirurgie. 2014;13(3):96-100.

    4. Rogers R. Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats. International Journal of Impotence Research. 2003;15:S24-9.

    5. Lamina S, Agbanusi E, Nwacha RC. Effects of Aerobic Exercise in the Management of Erectile Dysfunction: A Meta Analysis Study on Randomized Controlled Trials. Ethiopian Journal of Health Sciences. 2011;21(3):195-201.

    6. Esposito K, Giugliano F, Di Palo C, et al. Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men: A Randomized Controlled Trial. JAMA. 2004;291(24):2978-2984. doi:10.1001/jama.291.24.2978.

    7. Nikolai S. Erection rehabilitation following prostatectomy–current strategies and future directions. Nature Reviews Urology. 2016;13(.):216-225.

    8. Pahlajani G,Raina R, Jones S, Ali M, and Zippe C. Vacuum erection devices revisited: Its emerging role in the treatment of erectile dysfunction and early penile rehabilitation following prostate cancer therapy. J Sex Med 2012;9:1182–1189.

    9. Sellers T, Dineen M, Wilson SK. Vacuum protocol and cylinders that lengthen allow implantation of longer, inflatable prosthesis. Toronto, ON: (Abst) Society of Sexual Medicine; 2008.

    10. Raheem A. The role of vacuum pump therapy to mechanically straighten the penis in Peyronie’s disease. BJU Int.. 2016;117(4):E7.

    11. Levine L. Peyronie’s disease: contemporary review of non-surgical treatment. Transl. Androl. Urol. 2013;2(1):39-44.

    12. Safarinejad M. Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie’s disease: a double-blind, placebo-controlled randomized study. International Journal of Impotence Research. 2010;22(5):298-309.

    13. Paulis G. Efficacy of vitamin E in the conservative treatment of Peyronie’s disease: legend or reality? A controlled study of 70 cases. Andrology. 2013;1(1):120-128.

    14. Lue T. The Challenges of Peyronie’s disease. Translational Andrology & Urology. 2012;1(S1):PS 9.

    15. Raynor M. Dorsal Penile Nerve Block Prior to Inflatable Penile Prosthesis Placement: A Randomized, Placebo‐Controlled Trial. The Journal of Sexual Medicine. 2012;9(11):2975-2979.

    16. Sanchez-Gonzales J. Platelet-Rich Plasma Peptides: Key for Regeneration. International Journal of Peptides. 2012;10:1-10.

    17. Taylor D. A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries.. Clin J Sport Med. 2011;21(4):344-52.

    18. Yuan T, Zhang C-Q, Wang JH-C. Augmenting tendon and ligament repair with platelet-rich plasma (PRP). Muscles, Ligaments and Tendons Journal. 2013;3(3):139-149.

    19. Sell S. A case report on the use of sustained release platelet-rich plasma for the treatment of chronic pressure ulcers. The Journal of Spinal Cord Medicine. 2011;34(1):122-7.

    20. Conde-Montero, E., Horcajada-Reales, C., Clavo, P., Delgado-Sillero, I. and Suárez-Fernández, R. (2014), Neuropathic ulcers in leprosy treated with intralesional platelet-rich plasma. Int Wound J. doi:10.1111/iwj.12359

    21. Ding X. The effect of platelet-rich plasma on cavernous nerve regeneration in a rat model.. Asian J Androl. 2009;11(2):215-21.

    22. Ding X. Platelet-rich plasma on the Cavernous Nerve Regeneration. Chinese Medical journal. 2008;88(36):2578-2580.

    23. Rene’ Y. Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postradical Prostatectomy Erectile Dysfunction: An Open Dose-Escalation Pilot Study. European Urology. 2016;69(6):988-991.

    24. Fandel T. Recruitment of Intracavernously Injected Adipose-Derived Stem Cells to the Major Pelvic Ganglion Improves Erectile Function in a Rat Model of Cavernous Nerve Injury. European Urology. 2012;61(1):201-210.

    25. Singh S. Role of platelet-rich plasma in chronic alopecia areata: Our centre experience.. Indian Journal of Plastic Surgery. 2015;48(1):57-9.

    26. Goldstein A. ISSVD 2015 Abstracts. Autologous Platelet Rich Plasma (PRP) Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus. Journal of Lower Genital Tract Disease. 2015;19(3):S1-S25.

    27. Goldstein A., Runels C. Intradermal Injection of autologous platelet-rich plasma for the treatment of vulvar Lichen sclerosus. Journal of the American Academy of Dermatology. 2017;76(1):158-160

    27. Zaman H. Association of psychological factors, patients’ knowledge, and management among patients with erectile dysfunction. Patient Preference and Adherence. 2016;10:807.

    Save

    Save

  • Peyronie’s & ED Treatment: The Priapus Shot® Procedure

    Priapus Shot® Procedure

    The Priapus Shot® procedure indicates a specific protocol for treating the penis with blood-derived growth factors: specifically platelet-rich plasma or PRP. The name Priapus Shot® is registered with the US Patent & Trademark office as a “service mark” to protect patients by indicating a specific protocol. The name is not a synonym for the injection of blood in to the penis—such a definition would not be specific enough to warrant protection as intellectual property and so would not indicate any particular quality of care.

    The trademark gives a method of teaching a specific protocol that providers agree to follow and develop; this agreement offers a measure of quality control and is being followed and developed by around 500 urologists and interventional radiologists, family practitioners, and internists in multiple countries and by faculty in several medical schools where further studies are being done.

    The Priapus Shot® procedure defines a protocol that involves patient selection, patient evaluation & education (including explanation of consent), preparation of the PRP, local anesthesia, PRP injection, post injection use of a penis pump on a daily basis, and a daily dose of Tadalafil. Other post injection steps can include: stopping smoking, CoQ10 (12), vitamin E (13), Trimix, and aerobic exercise. Protocol steps can vary depending on the problems presented by the patient.

    It is the policy of most of our providers of the procedure to offer any patient that is not happy with the Priapus Shot® procedure a complete refund.

    Find Priapus Shot® Provider <–

    Patient selection includes identifying those who may need hormonal treatment, or family counseling, or vascular surgery, as well as those who may have co-morbidities or who may be taking drugs that interfere with sexual function. Some patients are not treated with the Priapus Shot® protocol because another treatment or no treatment is more appropriate.

    Consulting the patient includes informing him that unexpected side effects could occur and the results can vary with some patients seeing no benefit.

    The preparation of the PRP involves a device approved by the FDA for isolating PRP from whole blood for autologous use. Since blood is not a drug, it is not governed by the FDA. Multiple kits have gained FDA approval. Some of the approved kits include Regen, Magellan, TruPRP, Eclipse, Pure Spin, & Emcyte. There are over 8,000 papers on pub med discussing the science of PRP, and not one serious side effect has been documented when FDA approved kits were used to prepare the PRP.

    The first indication that PRP may be useful in the penis is in a paper published in Urology in 2003 indicating that, in animal models, using growth factors was successful to treat erectile dysfunction and indicated that such a strategy may be feasible in men— actually providing a way to correct underlying pathology (1). Viagra and Trimix do not correct underlying pathology of penile circulation.

    Another animal model study in 2010 showed that transferring adipocyte derived stem cells (ADSCs) into the penis caused endothelia cell growth as well as increased nitric oxide activity in the dorsal nerve. Interestingly, the ADSCs were tagged and perished – so the improvement seen was not from maturation of the ADSCs but rather from recruitment and activation by growth factors of stem cells from within the body. Also, indicating the PRP may demonstrate a similar effect (2).

    Dr. Virag (also a pioneer of Trimix injections) published a paper demonstrating improvement in erectile function, size, and correction of Peyronie’s disease with the use of PRP. His studies both published (and to be published) demonstrate a mean increase of 7 on the ED Intensity Score when PRP is injected into the plaque and the corpus cavernosum of the human penis (3).

    One of the growth factors (over 20 known) found in PRP includes vascular endothelial growth factor (VEGF). In one animal model study, the animals were castrated to create a penis that demonstrated, on microscopy, atrophy of smooth muscle and nerves as well as endothelial cell pathology. Injecting VEGF directly into the corpus cavernosum prevented the atrophy as effectively as did testosterone replacement. Moreover, VEGF reversed cavernosoetric findings of leakage (4).

    The above studies and others not cited indicate an improvement in the health, circulation, and strength (density) of penile tissue.

    In regards to improvement in erection firmness, the Priapus Shot® protocol also includes a recommendation of aerobic exercise which by metaanalysis of 5 randomized controlled studies using the IIEF showed an increase of 5 (5,6).

    As previously stated, the complete Priapus Shot® protocol, also includes the use of a penis pump, which as a stand-alone therapy has been demonstrated to improve erection both as part of a penile rehabilitation program as well as an adjunct to other therapies (7,8).

    This same penis pump strategy, even without the PRP, has been demonstrated to increase penis size by 2-3 cm, while traction (another physical therapy that can be included as part of the Priapus Shot® protocol) was shown to increase penis length by 1.5-2.5 cm (8, 9). Adding PRP to the protocol shows improved results according to data collected by urologists currently utilizing the Priapus Shot® protocol – to be presented later this year. It should be noted that the 2.5 cm improvement seen with the penis pump alone is in the 10-20% growth range for the average sized penis. As previously stated, while patient results vary, any patients that are not happy with the procedure are given a complete refund.

    Ultrasound studies of humans, post treatment, by Dr. Virag and by the physicians currently utilizing the Priapus Shot® protocol demonstrate improved blood flow and an increase in endothelium (improved health) as well as such results being indicated animal model studies, only some of which have been cited.

    Dr. Virag’s studies, using the injection of PRP as a stand-alone (without physical therapies), also demonstrate improvement in the angle of the penis in men suffering with Peyronie’s disease (3). Also, strict adherence to a penis pump regimen is part of the Priapus Shot® protocol and the pump alone improves the angle significantly in over one-half of those studied in one study in the British Journal of Urology (10). This same study demonstrated growth of the penis using the pump alone (without the PRP injection) though the growth was not as significant as in the other studies previously cited. The PRP alone, in Dr Virag’s study, out-performed the pump with demonstration of remodeling of the plaque.

    Studies show that the non-surgical treatment of Peyronie’s is most effective when a synergy of multiple modalities is engaged (11). So, the Priapus Shot® procedure includes the injection of PRP (demonstrated effective by Dr. Virag) combined with daily physical therapy using a penis pump for ten minutes twice a day and a daily low-dose of Taladafil. Further, other modalities are also used in the Priapus Shot® procedure that have been demonstrated to be synergistic: stopping smoking, CoQ10 (12), vitamin E (13), Trimix, and aerobic exercise. Such strategies are not intended to take the place of surgical correction or of the use of chemical surgery with collagenase—but rather to offer the man suffering with Peyronie’s disease the optimal non-surgical treatment as a first step with surgery reserved if non-surgical therapies fail.

    The Priapus Shot® protocol does not intend to make any particular therapy obsolete but rather offer a protocol for enhancing an overall, synergistic approach to pathology of the penis. The surgical treatment of Peyronie’s disease can be unsatisfying and lead to serious complications (14); we are seeing the safety profile of PRP and the Priapus Shot® protocol offer an appealing conservative step to take before proceeding to surgery.

    For, example the penis pump alone (part of the Priapus Shot® protocol) has been shown to improve the effectiveness of Cialis and of Trimix injections (8). We are seeing men decrease the dosage of Viagra and/or Trimix by about 50 percent when the complete Priapus Shot® protocol is used.

    Most men find the procedure very comfortable if a topical lidocaine cream is used since a 1/2 inch 30 gauge needle is used for injection (similar to a Trimix injection). However, some men do ask for a dorsal nerve block which can easily be done using 1% lidocaine without epinephrine for a near painless procedure (since this same block can be used for prosthesis placement, it makes a 30 gauge needle completely painless for most men) (15).

    Considering the duration of effectiveness and risks involved it’s useful to consider the nature of the cell biology employed. A review article considering the basic science discusses the fact that the autologous growth factors are exactly what’s generated to propagate healing should the man have surgery. The healing peptides, chemotactic factors, and pluripotent stem cells employed are exactly what’s generated by the normal healing process and offered no inherent risk for infection or allergy (16).

    In over 8,000 papers published about PRP on pub med, there is not one serious sequelae reported that I can identify (multiple review article speaks of the safety). This seems logical when you consider the material being injected is autologous and normally produced to help healing and to fight infection.

    Wound care studies demonstrate the nature of multiple tissue types being regenerated (with no reported risk of neoplasia in multiple biopsy studies (17-20).

    Moreover, in rat studies (where biopsy of the dorsal nerve is feasible), PRP has been shown to help regenerate nerve tissue and restore erectile function when prostate surgery is modeled with crush injury to the dorsal nerve (21,22). Some studies of stem cell therapies demonstrate that the stem cells do not actually mature into healthy tissue but rather signal for the improvement of the involved ganglion and nerve conduction by recruitment of stem cells to the area – exactly what happens with PRP.

    Stem cells are not directly prepared as part of the Priapus Shot® procedure, but we are seeing similar results as what’s reported with stem cell studies. Stem Cell studies often use PRP as a carrier for the stem cells, bringing into question which is the active agent (23-24).

    The idea of safety is further emphasized by the literature indicating that not only are there no reports of serious allergic reactions to PRP, but research also shows that PRP can attenuate the autoimmune response. One split-scalp study (with placebo control) showed improvement in alopecia areata, with the use of PRP, that out-performed triamcinolone (25). Another study using PRP in the genitalia of women, showed improvement in lichen sclerosus as determined by both patient survey and by 2 blinded dermatopathologists (26). This attribute of PRP, that of attenuation of the autoimmune response, could partly explain the effectiveness of the Priapus Shot® protocol for the treatment of both Peyronie’s disease and erectile dysfunction.

    In summary, multiple studies support the idea that blood-derived growth factors (when prepared in a proper way using a kit approved by the FDA for the preparation of PRP), as used in the Priapus Shot® protocol, support the health and function of the penis. Erectile dysfunction is associated with anhedonia, and successful treatment leads to better function, better relationships, and more pleasure in life (27).

    References

    1. Siroky M. Vasculogenic erectile dysfunction: newere therapeutic strategies. J Urol. 2003;170(2 Pt 2):S24-9.

    2. Garcia MM, Fandel TM, Lin G, Shindel AW, Banie L, LinC-S, and Lue TF. Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells. J Sex Med 2010;7:89–98

    3. Virag R. A New Treatment of Lapeyronie’s Disease by Local Injections of Plasma Rich Platelets (PRP) and Hyaluronic Acid. Preliminary Results. e-mémoires de l’Académie Nationale de Chirurgie. 2014;13(3):96-100.

    4. Rogers R. Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats. International Journal of Impotence Research. 2003;15:S24-9.

    5. Lamina S, Agbanusi E, Nwacha RC. Effects of Aerobic Exercise in the Management of Erectile Dysfunction: A Meta Analysis Study on Randomized Controlled Trials. Ethiopian Journal of Health Sciences. 2011;21(3):195-201.

    6. Esposito K, Giugliano F, Di Palo C, et al. Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men: A Randomized Controlled Trial. JAMA. 2004;291(24):2978-2984. doi:10.1001/jama.291.24.2978.

    7. Nikolai S. Erection rehabilitation following prostatectomy–current strategies and future directions. Nature Reviews Urology. 2016;13(.):216-225.

    8. Pahlajani G,Raina R, Jones S, Ali M, and Zippe C. Vacuum erection devices revisited: Its emerging role in the treatment of erectile dysfunction and early penile rehabilitation following prostate cancer therapy. J Sex Med 2012;9:1182–1189.

    9. Sellers T, Dineen M, Wilson SK. Vacuum protocol and cylinders that lengthen allow implantation of longer, inflatable prosthesis. Toronto, ON: (Abst) Society of Sexual Medicine; 2008.

    10. Raheem A. The role of vacuum pump therapy to mechanically straighten the penis in Peyronie’s disease. BJU Int.. 2016;117(4):E7.

    11. Levine L. Peyronie’s disease: contemporary review of non-surgical treatment. Transl. Androl. Urol. 2013;2(1):39-44.

    12. Safarinejad M. Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie’s disease: a double-blind, placebo-controlled randomized study. International Journal of Impotence Research. 2010;22(5):298-309.

    13. Paulis G. Efficacy of vitamin E in the conservative treatment of Peyronie’s disease: legend or reality? A controlled study of 70 cases. Andrology. 2013;1(1):120-128.

    14. Lue T. The Challenges of Peyronie’s disease. Translational Andrology & Urology. 2012;1(S1):PS 9.

    15. Raynor M. Dorsal Penile Nerve Block Prior to Inflatable Penile Prosthesis Placement: A Randomized, Placebo‐Controlled Trial. The Journal of Sexual Medicine. 2012;9(11):2975-2979.

    16. Sanchez-Gonzales J. Platelet-Rich Plasma Peptides: Key for Regeneration. International Journal of Peptides. 2012;10:1-10.

    17. Taylor D. A systematic review of the use of platelet-rich plasma in sports medicine as a new treatment for tendon and ligament injuries.. Clin J Sport Med. 2011;21(4):344-52.

    18. Yuan T, Zhang C-Q, Wang JH-C. Augmenting tendon and ligament repair with platelet-rich plasma (PRP). Muscles, Ligaments and Tendons Journal. 2013;3(3):139-149.

    19. Sell S. A case report on the use of sustained release platelet-rich plasma for the treatment of chronic pressure ulcers. The Journal of Spinal Cord Medicine. 2011;34(1):122-7.

    20. Conde-Montero, E., Horcajada-Reales, C., Clavo, P., Delgado-Sillero, I. and Suárez-Fernández, R. (2014), Neuropathic ulcers in leprosy treated with intralesional platelet-rich plasma. Int Wound J. doi:10.1111/iwj.12359

    21. Ding X. The effect of platelet-rich plasma on cavernous nerve regeneration in a rat model.. Asian J Androl. 2009;11(2):215-21.

    22. Ding X. Platelet-rich plasma on the Cavernous Nerve Regeneration. Chinese Medical journal. 2008;88(36):2578-2580.

    23. Rene’ Y. Safety of Intracavernous Bone Marrow-Mononuclear Cells for Postradical Prostatectomy Erectile Dysfunction: An Open Dose-Escalation Pilot Study. European Urology. 2016;69(6):988-991.

    24. Fandel T. Recruitment of Intracavernously Injected Adipose-Derived Stem Cells to the Major Pelvic Ganglion Improves Erectile Function in a Rat Model of Cavernous Nerve Injury. European Urology. 2012;61(1):201-210.

    25. Singh S. Role of platelet-rich plasma in chronic alopecia areata: Our centre experience.. Indian Journal of Plastic Surgery. 2015;48(1):57-9.

    26. Goldstein A. ISSVD 2015 Abstracts. Autologous Platelet Rich Plasma (PRP) Intradermal Injections for the Treatment of Vulvar Lichen Sclerosus. Journal of Lower Genital Tract Disease. 2015;19(3):S1-S25.

    27. Goldstein A., Runels C. Intradermal Injection of autologous platelet-rich plasma for the treatment of vulvar Lichen sclerosus. Journal of the American Academy of Dermatology. 2017;76(1):158-160

    27. Zaman H. Association of psychological factors, patients’ knowledge, and management among patients with erectile dysfunction. Patient Preference and Adherence. 2016;10:807.

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