Priapus Shot® (P-Shot®) Procedure Research

  • Dachille, Giuseppe, Andrea Panunzio, Leonardo Bizzotto, Maria Valeria D’Agostino, Federico Greco, Giuseppe Guglielmi, Umberto Carbonara, et al. “Platelet-Rich Plasma Intra-Plaque Injections Rapidly Reduce Penile Curvature and Improve Sexual Function in Peyronie’s Disease Patients: Results from a Prospective Large-Cohort Study.” World Journal of Urology 43, no. 1 (May 15, 2025): 306. https://doi.org/10.1007/s00345-025-05691-5.
  • Israeli, Joseph M., Soum D. Lokeshwar, Iakov V. Efimenko, Thomas A. Masterson, and Ranjith Ramasamy. “The Potential of Platelet-Rich Plasma Injections and Stem Cell Therapy for Penile Rejuvenation.” International Journal of Impotence Research, November 6, 2021, 1–8. https://doi.org/10.1038/s41443-021-00482-z.
  • Poulios, Evangelos, Ioannis Mykoniatis, Nikolaos Pyrgidis, Filimon Zilotis, Paraskevi Kapoteli, Dimitrios Kotsiris, Dimitrios Kalyvianakis, and Dimitrios Hatzichristou. “Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.” Journal of Sexual Medicine 18, no. 5 (May 1, 2021): 926–35. https://doi.org/10.1016/j.jsxm.2021.03.008.  A very helpful study; but, interesting that they did this study and claim to be “the first clinical trial exploring the role of PRP in the management of ED” as if all the other papers on this page do not exist.
  • Bosma-Den Boer, Margarethe M., Marie Louise Van Wetten, and Leo Pruimboom. “Chronic Inflammatory Diseases Are Stimulated by Current Lifestyle: How Diet, Stress Levels and Medication Prevent Our Body from Recovering.” Nutrition and Metabolism 9 (2012). https://doi.org/10.1186/1743-7075-9-32.
  • Casabona, Francesco, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, and Ilaria Baldelli. “Autologous Platelet-Rich Plasma (PRP) in Chronic Penile Lichen Sclerosus: The Impact on Tissue Repair and Patient Quality of Life.” International Urology and Nephrology 49, no. 4 (April 2017): 573–80. https://doi.org/10.1007/s11255-017-1523-0.

  • Chung. “A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction.” Medical Sciences 7, no. 9 (August 29, 2019): 91. https://doi.org/10.3390/medsci7090091.
  • Chung, Eric. “Medical Sciences A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction,” 2019, 1–11.
  • Everts, Peter, Kentaro Onishi, Prathap Jayaram, José Fábio Lana, and Kenneth Mautner. “Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.” International Journal of Molecular Sciences 21, no. 20 (October 21, 2020): 7794. https://doi.org/10.3390/ijms21207794.
  • Kumar, C.S. “265 Combined Treatment of Injecting Platelet Rich Plasma With Vacuum Pump for Penile Enlargement.” The Journal of Sexual Medicine 14, no. 1 (January 2017): S78. https://doi.org/10.1016/j.jsxm.2016.11.174

  • Lee, Ping-Jui, Yuan-Hong Jiang, and Hann-Chorng Kuo. “A Novel Management for Postprostatectomy Urinary Incontinence: Platelet-Rich Plasma Urethral Sphincter Injection.” Scientific Reports | 11 (123AD): 5371. https://doi.org/10.1038/s41598-021-84923-1.
  • Littara, A., B. Palmieri, V. Rottigni, and T. Iannitti. “A Clinical Study to Assess the Effectiveness of a Hyaluronic Acid-Based Procedure for Treatment of Premature Ejaculation.” International Journal of Impotence Research 25, no. 3 (2013). https://doi.org/10.1038/ijir.2013.13.
  • Liu, Ming-Che, Meng-Lin Chang, Ya-Chun Wang, Wei-Hung Chen, Chien-Chih Wu, and Shauh-Der Yeh. “Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction.” Cells 9, no. 5 (May 19, 2020): 1250. https://doi.org/10.3390/cells9051250.
  • Matz, Ethan L, Amy M Pearlman, and Ryan P Terlecki. “Safety and Feasibility of Platelet Rich Fibrin Matrix Injections for Treatment of Common Urologic Conditions.” Investigative and Clinical Urology 59, no. 1 (January 2018): 61–65. https://doi.org/10.4111/icu.2018.59.1.61.
  • Raheem, Amr Abdel, Giulio Garaffa, Tarek Abdel Raheem, Michelle Dixon, Amanda Kayes, Nim Christopher, and David Ralph. “The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie’s Disease.” BJU International 106, no. 8 (2010): 1178–80. https://doi.org/10.1111/j.1464-410X.2010.09365.x. We use the P-Shot® in combination with Vacuum Pump to treat Peyronie’s disease (click to see more)<-
  • Ruffo, A., M. Franco, E. Illiano, and N. Stanojevic. “Effectiveness and Safety of Platelet Rich Plasma (PrP) Cavernosal Injections plus External Shock Wave Treatment for Penile Erectile Dysfunction: First Results from a Prospective, Randomized, Controlled, Interventional Study.” European Urology Supplements 18, no. 1 (March 2019): e1622–23. https://doi.org/10.1016/S1569-9056(19)31175-3.
  • Towe, Maxwell, Akhil Peta, Russell G. Saltzman, Navin Balaji, Kevin Chu, and Ranjith Ramasamy. “The Use of Combination Regenerative Therapies for Erectile Dysfunction: Rationale and Current Status.” International Journal of Impotence Research, July 12, 2021, 1–4. https://doi.org/10.1038/s41443-021-00456-

The following lecture regards the female genitalia, but the ideas carry over to the male genitalia…

The Forces Affected by Penis Pump
Find the nearest Priapus Shot® provider (those not on this list are not certified to do the procedure and are illegal imposters) Click<--
  1. Peyronie’s Disease.  This text gives an excellent review of the various treatments for Peyronie’s disease.  It was written 5 years after the Priapus Shot® procedure was invented. Page 164 refers to the Priapus Shot® procedure.
  2. With surgery, “recurrence and ED rates[s] are high and some patients may experience permanent loss of sensation.” “…not acceptable to many patients because the ‘loss’ of penile length.”
  3. Combination therapy works better than one therapy alone (there can be a synergy).
  4. Pump therapy corrected 51% of men-– satisfied with pump therapy alone (10 minutes twice a day). They did no other therapy in combination with the pump.  Side effect was increase in length. This study in rats shows why the pump may help (click).
  5. CoQ10 in double blind study.
  6. Vitamin E. 1,200 IU daily.
  7. Platelet rich plasma plasma for fibrosis and scar treatment.
  8. Platelet rich plasma for autoimmune.
  9. Platelet rich plasma for lichen sclerosus.
  10. PRP supporting Priapus Shot® for Peyronie’s Disease
  11. Another study indicating that the Priapus Shot® could be more beneficial and with fewer side effects than Xiapex for Peyronie’s
  12. Correct Testosterone deficiency to help Peyronie’s.  Here’s a link to all the tests I normally do.
  13. Walking associated with decreased inflammation and improved erection. For full benefit, it’s best if the man works up to 21-25 miles per week.
  14. Cialis daily alone or in combination.
  15. Safety Information about Xiaflex (collagenase).
    Notice that the rate of ED is 0.4% in placebo and 1.8% in the Xiaflex group
    –> So, the implied incidence of ED from Xiafex would be 1.8 – 0.4 = 1.4% Also, note that the rate of known rupture from Xiaflex is 0.5%.  The rate of possible rupture (heard a popping sound or extensive bruising, etc.) was 0.9%. 
    0.5 + 0.9 = 1.4% (click here to see the warning box).  So, both of those stats support a rate of rupture/ED secondary to Xiaflex would be around 1.4% or 1 in 70.
  16. Physicians and nurse practitioners click to apply to join our group of Priapus Shot® providers.
Since the tissue is analogous, it may be helpful to also consider research regarding the O-Shot® procedure<--

Apply to participate in future research regarding the Priapus Shot® procedure…

Find the Nearest Priapus Shot® Provider (those not on this list who claim to be doing the Priapus Shot® procedure are not certified to do the procedure) Click<–

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