Tag: prp

  • JCPM2025.05.20 | Peyronie’s Disease | Scleroderma | PRF vs. PRP

    Journal Club with Pearls & Marketing 2025.05.20                   Cellular Medicine Association

    JCPM2025.05.20

    The following is an edited transcript of the Journal Club with Pearls & Marketing (JCPM) of May 20, 2025, with Charles Runels, MD.  

    >-> The PDF of this live journal club can be seen here <-<

    Topics Covered

    • PRP vs. PRF
    • Why Cleft Palate Repair Matters Even if You Only Care for Adult Women
    • PRP to Help with Chemotherapy
    • PRP Derived Exosomes for Wounds
    • When to Go With the Flow (and the Physician as a Person)
    • O-Shot® for Scleroderma
    • P-Shot® Procedure for Peyronie’s Disease
    • Here’s an Email You Could Send
    • References
    • Useful Links
    Charles Runels, MD

    Charles Runels, MD
    Author, researcher, and inventor of the Vampire Facelift®, Orchid Shot® (O-Shot®), Priapus Shot® (P-Shot®), Priapus Toxin®, Vampire Breast Lift®, and Vampire Wing Lift®, & Clitoxin® procedures.

    Transcript

    Welcome to our Journal Club.

    We have two very good, landmark, supportive papers of what we do and others of interest.

    Especially if you’re doing the P-Shot® or the O-Shot® procedures, you’re going to find today very encouraging.

    PRP vs. PRF

    In this first paper, I get so many questions about PRP versus PRF, and I include it here because of those questions.[1] 

    I like for us to think about all the different ideas. And part of the advantage of our group is that we are modifying our procedures as new science comes out and as our members think of new techniques. The dentistry profession was doing PRP at least a decade before we were with the idea that they had often hard to heal tissue with poor vascularization. And so they, out of necessity, went looking for ways to help with their surgery. And those in the GYN and the urology and facial plastic surgery space didn’t have to deal with that.

    So when I first picked up platelet-rich plasma in 2010, early 2010 when it was starting to make its way into cosmetic medicine, but not yet into sexual medicine, when I would speak with a dentist or veterinarians or even equestrians, they knew all about platelet-rich plasma. And the sports medicine people knew and the athletes knew, but most gynecologists did not know what it was about.

    For example, I taught a class up in Maine near the L.L. Bean store, and there was a lady who showed up as a model and she said, “Oh, we’ve been using this in our horses for years. So yes, I see what it does. I want an O-Shot®.”

    And so I like watching the dental research because they are a decade ahead of us. They quit wondering if platelet-rich plasma does anything and they’re more focused on the variations that might be used to make it work better.

    So I’m putting this here and it’ll be in the handouts when I shut down the meeting today. But clinically, my advantage of course is that I’m listening to our 2000-plus members and I’m hearing multiple problems arising when PRF is used with our procedures.

    => Apply for Online Training for Multiple PRP Procedures <=

    I’m still of the mind that PRF is more useful in wound care than in an O-Shot® or a P-Shot® or even cosmetic medicine.

    Problems with PRF

    One of our providers had a near miss with some signs of vascular occlusion when he put PRF in the lip and was able to recover circulation. But there were a few moments there of worry. And we don’t see that with PRP.

    It’s the same with the P-Shot®. I’ve received multiple emails from both patients and doctors describing problems with PRF that we don’t see with PRP.

    =>Next Hands-On Workshops with Live Models<=

    I’m not saying we don’t keep track of it, and I’m not saying there’s not usefulness in it, but so far I think if you’re doing P-Shots® or O-Shots® especially, and also for the Vampire Facelift®, I think you’re better off sticking with PRP instead of PRF.

    And I concede that at least something I say today will be proven wrong and absolutely wrong sometime in the future. But that’s what I’m seeing from the research, and I wanted you to have that.

    Why Cleft Palate Repair Matters Even if You Only Care for Adult Women

    Most of us don’t do cleft palate repair, but this is another paper that talks about how useful PRP is in that situation.[2] 

    And the reason I like these papers, even for those who are not doing facial plastic surgery, is of course we have similar problems when you’re treating an episiotomy scar or scarring of any kind: for example, the chronic sclerosis and scarring that happens with lichen sclerosus, in some ways Peyronie’s disease is remodeling a scar, and then sometimes we’re just treating scars where someone had an umbilical piercing or a surgical scar. I’ve treated basal cell scars from skin grafts, zoster scars, and of course acne scars.

    So I think it’s encouraging to see these papers come out that support that idea of using PRP to help with scars. I think one of the hindrances to medical progress is people, all of us, especially me, I try to force myself not to do this, but being caught in our fish tank, so to speak. And we’re looking at the research in our arena and not noticing other arenas.

    Of course, the same thing happens in business. So often the people who are successful in business just take an idea that’s succeeded in a different kind of business and just drag it over into theirs. When I started doing PRP in the genitalia, I was just treating the genitalia with the same idea that if causes neovascularization and neurogenesis and scar remodeling in the face, then it should happen with the scarring and vascular problems that happen in the vagina and the penis. And turns out that was a useful direction to go in. So having these papers, even if you’re not doing cleft palate repair, I think, is reassuring.

    PRP to Help with Chemotherapy

    This one, again, I don’t have as much of a direct usefulness for it too, but I’ve not seen anything in this category before: PRP for the side effects of chemotherapy.[3] 

    The effect of autologous cytokine-rich serum and platelet-rich plasma on oxidative status minerals and pro-inflammatory cytokines in the brain and serum and cyclophosphamide-induced ovarian failure. They took rats and they injected PRP and they documented: PRP therapies from the patient’s own blood have a potential as supportive or chemopreventive strategies with reduced side effects and treatment costs.

    So this is so early on, I’m not sure what to do with it, but I wanted us to be aware of it. And especially since we have so many types of physicians and some of you’re treating cancer, I wanted this on our radar so that some of you will actually come up with some good ideas. I think the fun thing that happens, as I just mentioned, is if you have your toe in two different arenas, then you might see things that others don’t see looking just in their fishbowl.

    Our variable backgrounds makes us able to come up with ideas that seem plain to one and not obvious to the other, I think that’s part of what happened with our Clitoxin® idea by having almost two decades of history of treating migraines and cosmetic use of botulinum toxin and thinking about how it might be working and reading that literature, and it became more obvious that it might be helpful for orgasm and sexual function in women when thinking about the feedback loops.[4] 

    And had I been sticking strictly to gynecology and didn’t have that two-decade history, it wouldn’t have been so obvious.

    Again, some of you are doing oncology, and you’ll think of ways to use this information that would never occur to me. So I just wanted to put it out there.

    PRP Derived Exosomes for Wounds

    And then a lot of you are talking about exosomes, so I wanted to show you this other paper. When I hear people talk about exosomes, to me it still feels even more misunderstood or poorly defined or ill-defined, I guess. Vaguely defined. More vaguely defined even than PRP because exosomes, are they homologous? Are they plant-based? Are they non-homologous or excuse me, autologous? Are they autologous, non-autologous, plant-based? Where are they coming from?

    => Apply for Online Training for Multiple PRP Procedures <=

    So they looked here at PRP and PRP-derived exosomes in wound healing.[5] 

    Some of you are using a source of exosomes that uses autologously derived exosomes with an outside processing company, and some of you are using plant-based exosomes that are something different. I think that the literature is leaning towards this strategy. Some of you are doing something called the Super Shot®, finding other ways to enhance the effects of our platelet-rich plasma.

    I don’t buy into the idea that if you’re over a certain age, your PRP is not at all effective, else if you did surgery, the skin wouldn’t heal. You couldn’t do a cholecystectomy on an 80-year-old. But I do agree that we need to keep looking for ways to enhance what we’re doing. And there’s an infinite number of variables.

    If you look on PubMed, there are now over 18,000 papers that come up if you put platelet-rich plasma in the search bar. When I first started doing and thinking about PRP in 2010, there were about 5,000.

     And already this year, we’re not halfway through the year, but we have half as many studies as we did last year. So there is a non-linear increase in the amount of research that’s being done. I think being tagged into our group and helping think about it, you are truly part of a revolution where regenerative therapies are not only becoming commonly done, but they’re becoming part of the standard protocols, but yet there’s still great need for understanding infinite number of variabilities in which they could be done.

    So this is just something to look at. I am still not doing exosomes when I do my O-Shot® and P-Shot® and I am getting great results, but I know some of you’re using it for hair or using it in place of PRP. I haven’t seen a study.

    The bottom line is the verdict is still out about we don’t have an answer about which actually works the best. And so I’m sticking with what I know has worked for over now almost a decade and a half, but keeping track of the rest of it.

    When to Go With the Flow

    I spoke with one of our providers and she says, “Everybody wants PRF now with their Vampire Facial®.” Okay, if you’re smearing it on the face and microneedling, does it really matter? They sell something on TikTok and that’s what they want. You just give it to them. It’s okay? But if you try to squirt that through a needle into the clitoris, then I think it’s a different thing. So sometimes you have to go with what they’re thinking.

    There was an old mentor of mine back in the days of medical school in the eighties who said, “Always try to integrate….” Actually, it was also in the book called The Physician Himself, which was written in 1882, said that you always try to integrate into your therapies what the patient wants.

    If they think that somehow taking vitamin C and smearing gravel from the street on their ear lobe will help their otitis media and you don’t see any harm to it, then you include it. Many things that were in the health food store, at which physicians scoffed, are now are prescription drugs.

    =>Next Hands-On Workshops with Live Models<=

    I try to integrate what I can without doing harm, without increasing expense if a patient wants something. And so yeah, I think it’s perfectly acceptable to use PRF if someone saw that on TikTok. But I think when you start trying to squirt it into the lip or the clitoris, you’re risking complications.

    O-Shot® for Scleroderma

    Okay, this one I brought out just because I have now heard even more people talk about our O-Shot® helping scleroderma. Of course, this is nanofat for cutaneous fibrosis and scleroderma, and they talk about using it in that instance, but it’s more support for what we’re seeing, which is that when you have someone coming to you for dyspareunia and dryness and the things that happen with scleroderma with female sexual function, it’s a indirect support of that.[6] We need more studies. If you want a low-hanging fruit, do a study and inject 50 women with dyspareunia and scleroderma and just do our regular O-Shot® and you’ll have a landmark study. But this would be support for that study.

    P-Shot® Procedure for Peyronie’s Disease

    I saved the best for last. They treated Peyronie’s disease and rapidly showed improvement with the injection of PRP.[7] And when they say rapid, this is rapid. If you remember the first study that I know of that came out about using our P-Shot® techniques for Peyronie’s disease was from Ronald Virag, out of Paris.[8] He was treating patients every once a week for six weeks. And these people just got treated three times.

    And so it went, first injection and then after two weeks, second injection, four weeks, and four weeks after the third injection, they measured. So they’re going not a long time. And the penile curvature, the plaque size, all improved.

    This one, they did not show improvement in erectile function that was statistical. If you look, here was the score.

    If you remember, our P-Shot® full effect is not until 12 weeks. So it was really early on for the neovascularization and neurogenesis, but there was still rapid plaque resolution with improvement. And there was no complications like are common with Xiaflex with penile fracture. So the side effect was a slight but not statistical improvement in erectile dysfunction, which is a good thing. They’d used an Angel systems, so it was a double spin centrifuge and they did inject the plaque.

    Now, many people in our group, some of them very high-volume injectors, are just doing a regular P-Shot® and combining it with the pump and seeing excellent results.

    You can palpate the plaque. So it’s not a big deal to do a regular P-Shot®, save a CC and just inject as if you were trying to inject intradermally. So when your needle goes into that plaque, you can feel it’s hard to push. So if you puncture it a few times and inject as you’re going through it, you can feel it. You don’t need an ultrasound. You can feel it. But for that, you will need to do a block. Otherwise, it’s tormenting.

    Even though they didn’t do it in this study, of course, because it would involve more than one variable and make it harder to reach statistical conclusions, we, as part of our protocol, combine the P-Shot® with a vacuum pump.

    In one study in the British Journal of Urology, 51% of men canceled their surgery just using the pump for 10 minutes a day for 12 weeks.[9] 

    And I spoke with Ronald Virag. We were at a meeting in Venice and I shared the podium with him. And he said, yes, in his study, he just used platelet-rich plasma. He used Regen, which is a single spin. But in clinical practice he combines it with a vacuum pump. I’ll show it to you. For the full protocol that I’m recommending, and until we have enough research to change it, can be found here<=

    If I’m treating someone for Peyronie’s, I send them to this page and tell them, “Do everything on the page.”

    The page includes a little video. I’ll have to add this paper, but includes links to the research supporting the ideas of what we’re doing.

    The seven-step plan talks about the pump, and there’s a link to the research. We actually have studies showing that CoQ10 and vitamin E that dose improve results.

    And then I have a protocol here. 

    Do the P-Shot®, wait six weeks. I think when you’re looking at the wound care studies, they’re usually separated by eight to 12 weeks. So if you’re pushing them that close together a week or two apart, you get results more quickly for your research paper, but if you are trying to preserve the patient’s time and money, it could be that if you separated it by six weeks, you’ll find what many of us have found, six to eight weeks, that they often don’t need a second or a third shot. They’re happy with it. So those are suggested timeframes between the injections.

    Low testosterone is associated with Peyronie’s. Adding testosterone hasn’t been shown to treat it, I don’t think. But because it’s associated, replace it.

    And then these others have more to do with erectile function. And again, aerobic fitness or VO2 max is associated with Peyronie’s disease, having low aerobic capacity, as is smoking. And not just with increased blood flow.

    There are some physiological reasons why Cialis every day could help not just the erection, but with resolution of Peyronie’s.

    So that’s the seven-step process. I’ll add this paper to the research.

    Here’s an Email You Could Send

    Remember, people don’t really care about an ad, but they like to read letters from you that include news. Because it’s news, if you are a P-Shot® provider, you could send them an email that talks about this new research and offer to help them (if you are not a P-Shot® provider, you can apply for online training here< ). Here’s a quick way to do get the email done:

    1. Copy and paste the following message into a new Word document.
    2. Then edit it so that it sounds like you.
    3. Add a story or a personal observation if you have time.
    4. Then, fill in the information with your phone number, etc., and send it to your patients.

    Envelope with solid fill

    Hello,

    Peyronie’s disease (a bending of the male genitalia) can be very serious and damage a marriage and the psychological well-being of man. New research just came out showing that using our P-Shot® ideas, you can improve male function and correct the curvature that can be so damaging to a family.

    Even better, it is truly shocking how fast it works.

    Here’s the research<=

    Here’s more about the whole protocol<=

    And you can see the side effects were none except for a slight increase in function. That was not statistic at this short interval.

    Also exciting, instead of risking the genitalia fracture that happens with Xiaflex (which is no longer approved for use in Canada, Europe, Japan, or Australia). And if you paid cash for Xiaflex, it would be a series of injections that would cost $27,000. Our procedure costs much less and has never caused a penile fracture.

    If you think this may help you or someone you love, please contact us.

    Sincerely,

    (your name)
    (your picture)
    (your website)
    (your phone number)
    (your email address)

    ____________________________________

    And as always, I offer people their money back if they’re not delighted.

    I know that frightens some people, but when you have a procedure that works the vast majority of the time, you still come out good.

    If you already know the patient and they’re familiar to you, let’s say that you’re their family practice doctor, you’ve already talked about the erectile dysfunction, I made a slight modification in the pricing. In that case, you could do that first injection for 997 or a thousand bucks if you want. But for a new patient coming in, you have to spend time with that person. And there’s going to be no insurance reimbursement if you’re all cash practice. And remember, the massage therapist gets 350 bucks for a six-month course. And you have to spin blood. You have cost of goods and your time. So 1800 is a very good price. It’s less than a new set of tires.

    But if you wanted to drop it for one of your current patients whom you already know, that would be okay. And we all do things for free, but we should all be advertising and telling people over the phone those prices so we’re not competing on price.

    And of course, if you add in our new ideas with Priapus Toxin® and putting a hundred units of Xeomin or some botulinum toxin similar into the penis along with your PRP, that would help with erectile dysfunction or could help as the studies show.[10] [11] [12] [13] [14]

    And that would be extra cost. I think that should be somewhere around an extra a thousand dollars to do that, a thousand to 1500, more if you’re in a town where it costs more money to turn on the lights. Let’s see. I think that’s all the questions, I think, and we come in right at 30 minutes. So hopefully that was helpful to you. Thank you for being here. See you next week.

    => Apply for Online Training for Multiple PRP Procedures <=

    =>Next Hands-On Workshops with Live Models<=

    References

    Acerra, Alfonso, Mario Caggiano, Andrea Chiacchio, Bruno Scognamiglio, and Francesco D’Ambrosio. “PRF and PRP in Dentistry: An Umbrella Review.” Journal of Clinical Medicine 14, no. 9 (May 6, 2025): 3224. https://doi.org/10.3390/jcm14093224.

    Dachille, Giuseppe, Andrea Panunzio, Leonardo Bizzotto, Maria Valeria D’Agostino, Federico Greco, Giuseppe Guglielmi, Umberto Carbonara, et al. “Platelet-Rich Plasma Intra-Plaque Injections Rapidly Reduce Penile Curvature and Improve Sexual Function in Peyronie’s Disease Patients: Results from a Prospective Large-Cohort Study.” World Journal of Urology 43, no. 1 (May 15, 2025): 306. https://doi.org/10.1007/s00345-025-05691-5.

    Elsamna, Samer T., Fayssal Alqudrah, Mahnoor Khan, Teagen Smith, Jon Robitschek, and Julia Toman. “Platelet Rich Products in Cleft Palate Repair.” The Cleft Palate Craniofacial Journal, May 16, 2025, 10556656251342003. https://doi.org/10.1177/10556656251342003.

    El-Shaer, Waleed, Hussein Ghanem, Tamer Diab, Ahmed Abo-Taleb, and Wael Kandeel. “Intra-Cavernous Injection of BOTOX® (50 and 100 Units) for Treatment of Vasculogenic Erectile Dysfunction: Randomized Controlled Trial.” Andrology 9, no. 4 (2021): 1166–75. https://doi.org/10.1111/andr.13010.

    Ermiş, Mustafa, Erol Karakaş, Hanifi Erol, Gökhan Akcakavak, Recai Aci, Furkan Ümit, Özhan Karatas, and Gülay Çiftci. “Effect of Autologous Cytokine-Rich Serum and Platelet-Rich Plasma Administration on Oxidative Status, Minerals and Proinflammatory Cytokines in Brain and Serum in Cyclophosphamide-Induced Ovarian Failure.” Journal of Molecular Histology 56, no. 3 (May 19, 2025): 159. https://doi.org/10.1007/s10735-025-10448-w.

    Giuliano, Francois, Pierre Denys, and Charles Joussain. “Effectiveness and Safety of Intracavernosal IncobotulinumtoxinA (Xeomin®) 100 U as an Add-on Therapy to Standard Pharmacological Treatment for Difficult-to-Treat Erectile Dysfunction: A Case Series.” Toxins 14, no. 4 (April 16, 2022): 286. https://doi.org/10.3390/toxins14040286.

    Habashy, Engy, and Tobias S. Köhler. “Botox for Erectile Dysfunction.” The Journal of Sexual Medicine 19, no. 7 (July 2022): 1061–63. https://doi.org/10.1016/j.jsxm.2022.03.216.

    He, Ling, Nan Zhao, Xiaoling Chen, Wenjie Zhang, Kun Lv, and Yuanhong Xu. “Platelet-Rich Plasma-Derived Exosomes Accelerate the Healing of Diabetic Foot Ulcers by Promoting Macrophage Polarization toward the M2 Phenotype.” Clinical and Experimental Medicine 25, no. 1 (May 15, 2025): 163. https://doi.org/10.1007/s10238-025-01651-w.

    Porter, Dr Mark. “Botox: The New Viagra? It’s One Way to Treat Erectile Dysfunction,” sec. times2. Accessed November 8, 2022. https://www.thetimes.co.uk/article/botox-could-help-men-beat-erectile-dysfunction-here-s-what-to-know-8x2vvt9c7.

    Raheem, Amr Abdel, Giulio Garaffa, Tarek Abdel Raheem, Michelle Dixon, Amanda Kayes, Nim Christopher, and David Ralph. “The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie’s Disease.” BJU International 106, no. 8 (2010): 1178–80. https://doi.org/10.1111/j.1464-410X.2010.09365.x.

    Runels, Charles, and Alexandra Runnels. “The Clitoral Injection of IncobotulinumtoxinA for the Improvement of Arousal, Orgasm & Sexual Satisfaction- A Specific Method and the Effects on Women.” Journal of Women’s Health Care 13, no. 3 No. 715 (March 20, 2024). https://doi.org/10.35248/2167-0420.24.13.715.

    Shehri, Zaed Ghassan, Issam Alkhouri, Mohammad Y Hajeer, Ibrahim Haddad, and Mohamad Husam Abu Hawa. “Evaluation of the Efficacy of Low-Dose Botulinum Toxin Injection Into the Masseter Muscle for the Treatment of Nocturnal Bruxism: A Randomized Controlled Clinical Trial.” Cureus, December 4, 2022. https://doi.org/10.7759/cureus.32180.

    Toro, Giuseppe Di, Angelo Alito, Giulia Leonardi, Fiorenza Giulia Di Toro, and Simona Portaro. “Nanofat and Lipofilling for Cutaneous Fibrosis in Scleroderma: Current Evidence and Future Directions,” n.d.

    Virag, Ronald, Hélène Sussman, Sandrine Lambion, and Valérie de Fourmestraux. “Evaluation of the Benefit of Using a Combination of Autologous Platelet Rich-Plasma and Hyaluronic Acid for the Treatment of Peyronie’s Disease.” Sexual Health Issues 1, no. 1 (2017). https://doi.org/10.15761/SHI.1000102.

    Tags

    P-Shot®, O-Shot®, PRP, PRF, platelet-rich plasma, Peyronie’s disease, erectile dysfunction, scleroderma, dyspareunia, cleft palate, wound healing, sexual medicine, cosmetic medicine, exosomes, regenerative medicine, PRP vs PRF, platelet-rich fibrin, PRP side effects, penile curvature, vacuum pump, Priapus Shot®, Vampire Facial®, Angel system, double spin centrifuge, Xiaflex alternatives, neurogenesis, neovascularization, autologous serum, cytokines, oxidative stress, chemotherapy side effects, facial plastic surgery, scar treatment, lichen sclerosis, episiotomy scars, acne scars, botulinum toxin, Priapus Toxin®, sexual function, testosterone, CoQ10, vitamin E, aerobic fitness, VO2 max, smoking and ED, PRP pricing, PRP injection protocol, regenerative protocols, PRP research, PRP in oncology, PRP and scleroderma, PRP complications, PRP enhancements, PRP marketing strategies, PRP for hair, autologous exosomes, Charles Runels

    Helpful Links

    => Next Hands-On Workshops with Live Models <=

    => Dr. Runels Botulinum Blastoff Course <=

    => The Cellular Medicine Association (who we are) <=

    => Apply for Online Training for Multiple PRP Procedures <=

    => FSFI Online Administrator and Calculator <=

    => 5-Notes Expert System for Doctors <=

    => Help with Logging into Membership Websites <=

    => The software I use to send emails: ONTRAPORT (free trial) <= 

    => Sell O-Shot® products: You make 10% with links you place; shipped by the manufacturer), this explains and here’s where to apply <=

    Charles Runels, MD             888-920-5311              CellularMedicineAssociation.org

    Page  of


    [1] Acerra et al., “PRF and PRP in Dentistry.”

    [2] Elsamna et al., “Platelet Rich Products in Cleft Palate Repair.”

    [3] Ermiş et al., “Effect of Autologous Cytokine-Rich Serum and Platelet-Rich Plasma Administration on Oxidative Status, Minerals and Proinflammatory Cytokines in Brain and Serum in Cyclophosphamide-Induced Ovarian Failure.”

    [4] Runels and Runnels, “The Clitoral Injection of IncobotulinumtoxinA for the Improvement of Arousal, Orgasm & Sexual Satisfaction- A Specific Method and the Effects on Women.”

    [5] He et al., “Platelet-Rich Plasma-Derived Exosomes Accelerate the Healing of Diabetic Foot Ulcers by Promoting Macrophage Polarization toward the M2 Phenotype.”

    [6] Toro et al., “Nanofat and Lipofilling for Cutaneous Fibrosis in Scleroderma: Current Evidence and Future Directions.”

    [7] Dachille et al., “Platelet-Rich Plasma Intra-Plaque Injections Rapidly Reduce Penile Curvature and Improve Sexual Function in Peyronie’s Disease Patients.”

    [8] Virag et al., “Evaluation of the Benefit of Using a Combination of Autologous Platelet Rich-Plasma and Hyaluronic Acid for the Treatment of Peyronie’s Disease.”

    [9] Raheem et al., “The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie’s Disease.”

    [10] Porter, “Botox.”

    [11] Habashy and Köhler, “Botox for Erectile Dysfunction.”

    [12] Shehri et al., “Evaluation of the Efficacy of Low-Dose Botulinum Toxin Injection Into the Masseter Muscle for the Treatment of Nocturnal Bruxism.”

    [13] Giuliano, Denys, and Joussain, “Effectiveness and Safety of Intracavernosal IncobotulinumtoxinA (Xeomin®) 100 U as an Add-on Therapy to Standard Pharmacological Treatment for Difficult-to-Treat Erectile Dysfunction.”

    [14] El-Shaer et al., “Intra-Cavernous Injection of BOTOX® (50 and 100 Units) for Treatment of Vasculogenic Erectile Dysfunction.”

  • New Research Shows Alternative Protocol to be Inferior to the P-Shot® (Priapus Shot®) Procedure

    New Research Shows Alternative Protocol to be Inferior to the P-Shot® (Priapus Shot®) Procedure

    Researchers (Masterson, 2023) recently used a protocol (that differs from the P-Shot® procedure) and measured the effect on erectile function of injections of the penis with platelet-rich plasma (PRP).

    Their protocol was less effective than what previous studies have shown. You can read the article here<–

    Before reviewing their research and their deviations from the P-Shot® protocol, consider what the P-Shot® is: The P-Shot® (Priapus Shot®) is a service mark that names a procedure that requires training in the standard protocol and an agreement to follow the protocol that has been used (with improvements) for the past 13 years.

    The ways Masterson, et al changed the procedure (from that of the P-Shot® procedure) for their study include at least all of the following:

    1. They used a different injection technique than what is used with the P-Shot® procedure; their technique limited the exposure of the penis to less than 1/2 of the tissue treated by the P-Shot® procedure.
    2. They used a centrifuge that is not on the recommended list of devices approved by the FDA for the preparation of PRP for injection back into the body. Their centrifuge also differs from what was used in other studies that showed benefits.  The centrifuge used can have dramatic effects on not only the number of platelets but also the number of white blood cells and red blood cells in the sample–all of which is important in regard to results.
    3. They injected 1/2 the volume of PRP usually injected. They injected a total of 5 cc instead of 10 or more cc’s. So not only did their injection technique limit the distribution, but the volume injected limited the treatment area and the number of platelets.
    4. They did not activate the PRP with Calcium Chloride (or with any agent at all). Without activation, the PRP is more prone to washout, and the growth factors in their 1/2 dose are further limited by being more shortlived than with the P-Shot® procedure. There is a huge difference between the growth factor spectrum and the duration of effect when the activation is modified.
      PRP can be modified by varying leukocyte count, platelet concentration, method of activation, and red blood cell count. (Sheean, 2021)

    Other points about the study:

    1. They calculated sample size based on the assumption that the placebo group would have a 15% rate of attaining MCID, not the observed 50%; so the study was grossly underpowered and conclusions invalid.  Still, we can look at more…


    2. Even though they saw less response (with their altered protocol) than what has been shown in other studies, they still saw improvement in erectile function after injection of PRP; the change was just not significantly greater than saline. Both showed improvement.


    3. Also, what they called a placebo, saline, has been shown to have regenerative properties when injected directly into tissue. When injected iv to compare with a drug, saline is an adequate placebo. When injected into tissue, it has been shown to help improve joint disease and help with leishmaniasis, granuloma annulare, and atrophic acne scars–saline, when injected into soft tissue, is not a placebo.

    “Even when used as a control, saline exerts some therapeutic action in different dermatological indications, including warts, acne scars, and rejuvenation.” (El-Amawy, 2020)


    4. In previous double-blind, placebo studies of PRP for ED, PDE5is were discontinued. In one study, the placebo response (still using saline) was only 15%. Masterson, et al allowed participants to continue their Viagra drugs, which could account for the higher placebo response. The high placebo response also attenuates the power of the study.


    5. The study is also compromised mathematically by a 15% dropout rate in an already small sample size.


    6. In their introduction, Masterson et. al writes the following: “Even without supporting data, numerous clinics in the largest metropolitan areas of the United States are charging patients for PRP treatments for ED.”

    Yet, there IS “supporting data.” Previous studies indeed have shown that PRP does help with ED and with Peyronie’s disease One of those studies was even done by Dr. Ronald Virag, the pioneer in urology who came up with the idea that became “tri-mix” injections for erection and changed urology forever.

    The near disappearance of plaque seen in Peyronie’s disease after injection with PRP (Virag, 2017)

    The authors failed to recognize all of those studies by stating there is “no supporting data.”


    7. They do, later in their discussion, contradict/correct their own statement (“no supporting data”) by making reference to two of many articles that support the P-Shot® procedure and the injection of PRP for ED.

    Then, they reference an article in JAMA that later required a printed correction; but make no reference to the correction, which undermines their point.


    8. Also, the authors fail to point out, in their worries about the money being charged, that the P-Shot® procedure has fewer side effects than Viagra (which has been shown to cause blindness in some) and its cousin drugs and that the cost of a P-Shot® can be less than pharmaceutical alternatives (over time), much less invasive and less expensive than a penile implant, and that P-Shot® providers have agreed to refund the money of anyone not helped by the procedure.

    The P-Shot® in no way makes these alternative treatments not useful and needed. But, the P-Shot® should be part of the tools available for treatment, and a man should be able to try the P-Shot® before proceeding to implant.


    9. Moreover, the Priapus Shot® procedure is NOT just to give a shot. The procedure includes an evaluation to see if the shot is appropriate. There must be phlebotomy (usually another skilled employee’s time and expense) and processing of blood using FDA kits approved for processing blood for autologous reinjection (not cheap). The cost to the patient helps covers these expenses.


    10. Other studies have shown a greater improvement in erectile function than what was seen by these authors. So, we are grateful for their contribution–showing that a different protocol works less well. Further studies are needed to look at the variables regarding the preparation of the PRP, activation, and injection technique to understand further why their protocol was less effective and how current protocols can be improved.

    Some of the supporting data for PRP for the treatment of ED.

    11. Also, further studies are needed regarding combination therapies. For example, one prospective, randomized, controlled study showed that PRP greatly improved the results seen with shock waves for erectile dysfunction.


    In conclusion, Masterson et al demonstrated (in this underpowered study using a placebo that is not a placebo) that injecting 1/2 the volume of the P-Shot® procedure using their alternative technique of injecting and not activating the PRP with CaCl is possibly less effective than what has been shown in other studies. That is valuable to know, and we are grateful for their study.


    To find the nearest P-Shot® (Priapus Shot® provider)<–

    To apply for training for the P-Shot® procedure<–

    Charles Runels, MD

    Charles Runels, MD
    Cellular Medicine Association
    1-888-920-5311
    DrRunels@Runels.com

    References

    References Regarding the Benefits of the P-Shot® Procedure for ED

    Bosma-Den Boer, Margarethe M., Marie Louise Van Wetten, and Leo Pruimboom. “Chronic Inflammatory Diseases Are Stimulated by Current Lifestyle: How Diet, Stress Levels and Medication Prevent Our Body from Recovering.” Nutrition and Metabolism 9 (2012). https://doi.org/10.1186/1743-7075-9-32.

     

    Casabona, Francesco, Ilaria Gambelli, Federica Casabona, Pierluigi Santi, Gregorio Santori, and Ilaria Baldelli. “Autologous Platelet-Rich Plasma (PRP) in Chronic Penile Lichen Sclerosus: The Impact on Tissue Repair and Patient Quality of Life.” International Urology and Nephrology 49, no. 4 (April 2017): 573–80. https://doi.org/10.1007/s11255-017-1523-0.

     

    Chung. “A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction.” Medical Sciences 7, no. 9 (August 29, 2019): 91. https://doi.org/10.3390/medsci7090091.

     

    Chung, Eric. “Medical Sciences A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction,” 2019, 1–11.

     

    Everts, Peter, Kentaro Onishi, Prathap Jayaram, José Fábio Lana, and Kenneth Mautner. “Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.” International Journal of Molecular Sciences 21, no. 20 (October 21, 2020): 7794. https://doi.org/10.3390/ijms21207794.

     

    Garcia, MM, TM Fandel, G Lin, AW Shindel, L Banie, CS Lin, and TF Lue. “Treatment of Erectile Dysfunction in the Obese Type 2 Diabetic ZDF Rat with Adipose Tissue-Derived Stem Cells,” 2010, 14.

     

    Israeli, Joseph M., Soum D. Lokeshwar, Iakov V. Efimenko, Thomas A. Masterson, and Ranjith Ramasamy. “The Potential of Platelet-Rich Plasma Injections and Stem Cell Therapy for Penile Rejuvenation.” International Journal of Impotence Research, November 6, 2021, 1–8. https://doi.org/10.1038/s41443-021-00482-z.

     

    Kumar, C.S. “265 Combined Treatment of Injecting Platelet Rich Plasma With Vacuum Pump for Penile Enlargement.” The Journal of Sexual Medicine 14, no. 1 (January 2017): S78. https://doi.org/10.1016/j.jsxm.2016.11.174.

     

    Lee, Ping-Jui, Yuan-Hong Jiang, and Hann-Chorng Kuo. “A Novel Management for Postprostatectomy Urinary Incontinence: Platelet-Rich Plasma Urethral Sphincter Injection.” Scientific Reports | 11 (123AD): 5371. https://doi.org/10.1038/s41598-021-84923-1.

     

    Liu, Ming-Che, Meng-Lin Chang, Ya-Chun Wang, Wei-Hung Chen, Chien-Chih Wu, and Shauh-Der Yeh. “Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction.” Cells 9, no. 5 (May 19, 2020): 1250. https://doi.org/10.3390/cells9051250.

     

    Matz, Ethan L, Amy M Pearlman, and Ryan P Terlecki. “Safety and Feasibility of Platelet Rich Fibrin Matrix Injections for Treatment of Common Urologic Conditions.” Investigative and Clinical Urology 59, no. 1 (January 2018): 61–65. https://doi.org/10.4111/icu.2018.59.1.61.

     

    Matz, Ethan L., Kyle Scarberry, and Ryan Terlecki. “Platelet-Rich Plasma and Cellular Therapies for Sexual Medicine and Beyond.” Sexual Medicine Reviews 10, no. 1 (January 2022): 174–79. https://doi.org/10.1016/j.sxmr.2020.07.001.

     

    Poulios, Evangelos, Ioannis Mykoniatis, Nikolaos Pyrgidis, Filimon Zilotis, Paraskevi Kapoteli, Dimitrios Kotsiris, Dimitrios Kalyvianakis, and Dimitrios Hatzichristou. “Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.” Journal of Sexual Medicine 18, no. 5 (May 1, 2021): 926–35. https://doi.org/10.1016/j.jsxm.2021.03.008.

     

    Raheem, Amr Abdel, Giulio Garaffa, Tarek Abdel Raheem, Michelle Dixon, Amanda Kayes, Nim Christopher, and David Ralph. “The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie’s Disease.” BJU International 106, no. 8 (2010): 1178–80. https://doi.org/10.1111/j.1464-410X.2010.09365.x.

     

    Ruffo, A., M. Franco, E. Illiano, and N. Stanojevic. “Effectiveness and Safety of Platelet Rich Plasma (PrP) Cavernosal Injections plus External Shock Wave Treatment for Penile Erectile Dysfunction: First Results from a Prospective, Randomized, Controlled, Interventional Study.” European Urology Supplements 18, no. 1 (March 2019): e1622–23. https://doi.org/10.1016/S1569-9056(19)31175-3.

     

    Schirmann, A., E. Boutin, A. Faix, and R. Yiou. “Pilot Study of Intra-Cavernous Injections of Platelet-Rich Plasma (P-Shot®) in the Treatment of Vascular Erectile Dysfunction.” Progrès En Urologie, June 2022, S1166708722001300. https://doi.org/10.1016/j.purol.2022.05.002.

     

    Shaher, Hussein, Abdallah Fathi, Salah Elbashir, Shabieb A. Abdelbaki, and Tarek Soliman. “Is Platelet Rich Plasma Safe And Effective In Treatment Of Erectile Dysfunction? Randomized Controlled Study.” Urology, February 2023, S0090429523000742. https://doi.org/10.1016/j.urology.2023.01.028.

     

    Siroky, Mike B., and Kazem M. Azadzoi. “Vasculogenic Erectile Dysfunction: Newer Therapeutic Strategies.” Journal of Urology 170, no. 2S (August 2003). https://doi.org/10.1097/01.ju.0000075361.35942.17.

     

    Towe, Maxwell, Akhil Peta, Russell G. Saltzman, Navin Balaji, Kevin Chu, and Ranjith Ramasamy. “The Use of Combination Regenerative Therapies for Erectile Dysfunction: Rationale and Current Status.” International Journal of Impotence Research, July 12, 2021, 1–4. https://doi.org/10.1038/s41443-021-00456-1.
    Masterson, Thomas A., Manuel Molina, Braian Ledesma, Isaac Zucker, Russell Saltzman, Emad Ibrahim, Sunwoo Han, Isildinha M. Reis, and Ranjith Ramasamy. “Platelet-Rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.” Journal of Urology, April 30, 2023, 10.1097/JU.0000000000003481. https://doi.org/10.1097/JU.0000000000003481.

    References Regarding P-Shot® Procedure for Peyronie’s Disease

    Culha, Mehmet Gokhan, Erkan Erkan, Tugce Cay, and Uğur Yücetaş. “The Effect of Platelet-Rich Plasma on Peyronie’s Disease in Rat Model.” Urologia Internationalis 102, no. 2 (2019): 218–23. https://doi.org/10.1159/000492755.

     

    Levine, Laurence A. “Peyronie’s Disease: Contemporary Review of Non-Surgical Treatment.” Translational Andrology and Urology 2, no. 1 (2013): 39–44. https://doi.org/10.3978/j.issn.2223-4683.2013.01.01.

     

    Raheem, Amr Abdel, Giulio Garaffa, Tarek Abdel Raheem, Michelle Dixon, Amanda Kayes, Nim Christopher, and David Ralph. “The Role of Vacuum Pump Therapy to Mechanically Straighten the Penis in Peyronie’s Disease.” BJU International 106, no. 8 (2010): 1178–80. https://doi.org/10.1111/j.1464-410X.2010.09365.x.

     

    Virag, Ronald, Hélène Sussman, Sandrine Lambion, and Valérie de Fourmestraux. “Evaluation of the Benefit of Using a Combination of Autologous Platelet Rich-Plasma and Hyaluronic Acid for the Treatment of Peyronie’s Disease.” Sexual Health Issues 1, no. 1 (2017). https://doi.org/10.15761/SHI.1000102.

     

    References Regarding Saline is Not a Placebo

    Asghar, Aneela, Zahid Tahir, Aisha Ghias, Usma Iftikhar, and Tahir Jameel Ahmad. “Efficacy and Safety of Intralesional Normal Saline in Atrophic Acne Scars.” Annals of King Edward Medical University 25, no. 2 (June 24, 2019). https://doi.org/10.21649/akemu.v25i2.2867.

     

    Bagherani, Nooshin, and Bruce R Smoller. “Introduction of a Novel Therapeutic Option for Atrophic Acne Scars: Saline Injection Therapy.” Global Dermatology 2, no. 6 (2016). https://doi.org/10.15761/GOD.1000159.

     

    Bokey, E. L., J. P. Keating, and P. Zelas. “HYDRODISSECTION: AN EASY WAY TO DISSECT ANATOMICAL PLANES AND COMPLEX ADHESIONS.” ANZ Journal of Surgery 67, no. 9 (September 1997): 643–44. https://doi.org/10.1111/j.1445-2197.1997.tb04616.x.

     

    Cass, Shane P. “Ultrasound-Guided Nerve Hydrodissection: What Is It? A Review of the Literature” 15, no. 1 (2016): 3.

     

    “Clinical Benefit of Intra-Articular Saline as a Comparator in Clinical Trials of Knee Osteoarthritis Treatments_ A Systematic Review and Meta-Analysis of Randomized Trials | Elsevier Enhanced Reader.” Accessed April 6, 2022. https://doi.org/10.1016/j.semarthrit.2016.04.003.

     

    El-Amawy, Heba Saed, and Sameh Magdy Sarsik. “Saline in Dermatology: A Literature Review.” Journal of Cosmetic Dermatology 20, no. 7 (2021): 2040–51. https://doi.org/10.1111/jocd.13813.

     

    Popp, Lothar W. “Improvement in Endoscopic Hernioplasty: Transcutaneous Aquadissection of the Musculofascial Defect and Preperitoneal Endoscopic Patch Repair.” Journal of Laparoendoscopic Surgery 1, no. 2 (January 1991): 83–90. https://doi.org/10.1089/lps.1991.1.83.

     

    Saltzman, Bryan M., Timothy Leroux, Maximilian A. Meyer, Bryce A. Basques, Jaskarndip Chahal, Bernard R. Bach, Adam B. Yanke, and Brian J. Cole. “The Therapeutic Effect of Intra-Articular Normal Saline Injections for Knee Osteoarthritis: A Meta-Analysis of Evidence Level 1 Studies.” The American Journal of Sports Medicine 45, no. 11 (September 1, 2017): 2647–53. https://doi.org/10.1177/0363546516680607.

     

    Searle, Tamara, Firas Al-Niaimi, and Faisal R. Ali. “Saline in Dermatologic Surgery.” Journal of Cosmetic Dermatology 20, no. 4 (2021): 1346–47. https://doi.org/10.1111/jocd.13996.

     

    Sharma, ReenaK, Mudita Gupta, and Ritu Rani. “Delineating Injectable Triamcinolone-Induced Cutaneous Atrophy and Therapeutic Options in 24 Patients—A Retrospective Study.” Indian Dermatology Online Journal 13, no. 2 (2022): 199. https://doi.org/10.4103/idoj.idoj_483_21.

     

    References Regarding the Activation of PRP

    Hamilton, Bruce, Johannes L. Tol, Wade Knez, and Hakim Chalabi. “Exercise and the Platelet Activator Calcium Chloride Both Influence the Growth Factor Content of Platelet-Rich Plasma (PRP): Overlooked Biochemical Factors That Could Influence PRP Treatment.” British Journal of Sports Medicine 49, no. 14 (July 1, 2015): 957–60. https://doi.org/10.1136/bjsports-2012-091916.

     

    Kao, David S., Stephanie W. Zhang, and Alexander R. Vap. “A Systematic Review on the Effect of Common Medications on Platelet Count and Function: Which Medications Should Be Stopped Before Getting a Platelet-Rich Plasma Injection?” Orthopaedic Journal of Sports Medicine 10, no. 4 (April 1, 2022): 232596712210888. https://doi.org/10.1177/23259671221088820.

     

    Sheean, Andrew J., Adam W. Anz, and James P. Bradley. “Platelet-Rich Plasma: Fundamentals and Clinical Applications.” Arthroscopy: The Journal of Arthroscopic & Related Surgery 37, no. 9 (September 2021): 2732–34. https://doi.org/10.1016/j.arthro.2021.07.003.

     

    Smith, Oliver J., Selim Talaat, Taj Tomouk, Gavin Jell, and Ash Mosahebi. “An Evaluation of the Effect of Activation Methods on the Release of Growth Factors from Platelet-Rich Plasma.” Plastic and Reconstructive Surgery 149, no. 2 (February 2022): 404–11. https://doi.org/10.1097/PRS.0000000000008772.

     

    Smith, Stephanie A., Richard J. Travers, and James H. Morrissey. “How It All Starts: Initiation of the Clotting Cascade.” Critical Reviews in Biochemistry and Molecular Biology 50, no. 4 (July 4, 2015): 326–36. https://doi.org/10.3109/10409238.2015.1050550.

     

    Toyoda, Toshihisa, Kazushige Isobe, Tetsuhiro Tsujino, Yasuo Koyata, Fumitaka Ohyagi, Taisuke Watanabe, Masayuki Nakamura, et al. “Direct Activation of Platelets by Addition of CaCl2 Leads Coagulation of Platelet-Rich Plasma.” International Journal of Implant Dentistry 4 (August 1, 2018): 23. https://doi.org/10.1186/s40729-018-0134-6.

     

    Ulasli, Alper Murat, Gokhan Tuna Ozturk, Bagdagul Cakir, Gulsemin Erturk Celik, and Fatih Bakir. “The Effect of the Anticoagulant on the Cellular Composition and Growth Factor Content of Platelet-Rich Plasma.” Cell and Tissue Banking, August 28, 2021. https://doi.org/10.1007/s10561-021-09952-6.

Arkadaşlarının evine her geldiklerinde kendisi gibi porno film azgın olan erkek arkadaşıyla sürekli arkadaşlarının porno izle evinde seks yaptıklarından dolayı çevresindeki tüm erkekler hd porno de onu sikmek istemektedir kız kıza dışarıya brazzers çıkan sürtükler karınları acıkınca bir restorana girip porno kafalarına göre bir masaya otururlar işi gereği mobil porno onlara hoş geldiniz diyerek yanlarına gelen garson konulu porno siparişleri almak için masaya gelir ve o sırada porno sürtüklere eğlence çıkar kızlardan biri diğer arkadaşına porn garsonu ayartmasını söyler diğeri de onu yaşlı bir porno izle adamla evlenmenin her kadın için zor olduğunu biliriz japon porno özellikle erkeklerin yaşlandıktan sonra ereksiyon sertleşme problemleri yaşadığını aşikar bir durumdur yine de bunu bile bile evlenmiş olduğu yaşlı adam ile seks yapacağını düşünen yaşlı kadın çok yanılır kocası tam bir pirpirim bitkisi gibi sikini kaldıramamıştır
Copyright - Disclaimer - Earnings - Privacy - Terms & Conditions
52 South Section St., Suite A, Fairhope, AL 36532 - 888-920-5311