Treating ED in Men Suffering from Diabetes

with many references ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌  ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌  ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌  ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ 

Hello [First Name],

A recent article appeared regarding the treatment of sexual dysfunction in men suffering from diabetes (Cayetanao-Alcaraz, 2023).
The following diagram alone (taken from the open-source article) made the article worth reading:

From Cayetano‐Alcaraz, 2023, read article here<–

At the bottom of this page, you will find references to research regarding some of the strategies covered in the infographic that are not as often discussed.
If you want specific training in two of the newer therapies for treating men suffering from the sexual dysfunction associated with diabetes, (1) Bocox™ (using Botox) and (2) the P-Shot® procedure (using PRP),
then here’s where physicians can apply for online training (click to see application)<—

Very best regards,

Charles

Charles Runels, MD

Cellular Medicine Assoicaton
1-800-928-5311
Next Hands-0n workshops with Live Models<—
Apply for Online Training for the Priapus Shot® procedure<–

References

Protocol for Treating the sexual dysfunction associated with Diabetes…

Cayetano‐Alcaraz AA, Tharakan T, Chen R, Sofikitis N, Minhas S. The management of erectile dysfunction in men with diabetes mellitus unresponsive to phosphodiesterase type 5 inhibitors. Andrology. 2023;11(2):257-269. doi:10.1111/andr.13257

Supporting Botox as part of the protocol

1. Porter DM. Botox: the new Viagra? It’s one way to treat erectile dysfunction.https://www.thetimes.co.uk/article/botox-could-help-men-beat-erectile-dysfunction-here-s-what-to-know-8x2vvt9c7. Accessed November 8, 2022.
2. Giuliano F, Denys P, Joussain C. Effectiveness and Safety of Intracavernosal IncobotulinumtoxinA (Xeomin®) 100 U as an Add-on Therapy to Standard Pharmacological Treatment for Difficult-to-Treat Erectile Dysfunction: A Case Series. Toxins. 2022;14(4):286. doi:10.3390/toxins14040286
3. Phan K, Younessi S, Dubin D, Lin MJ, Khorasani H. Emerging off‐label esthetic uses of botulinum toxin in dermatology. Dermatologic Therapy. 2022;35(1). doi:10.1111/dth.15205
4. Shehri ZG, Alkhouri I, Hajeer MY, Haddad I, Abu Hawa MH. Evaluation of the Efficacy of Low-Dose Botulinum Toxin Injection Into the Masseter Muscle for the Treatment of Nocturnal Bruxism: A Randomized Controlled Clinical Trial. Cureus. Published online December 4, 2022. doi:10.7759/cureus.32180
5. El-Shaer W, Ghanem H, Diab T, Abo-Taleb A, Kandeel W. Intra-cavernous injection of BOTOX® (50 and 100 Units) for treatment of vasculogenic erectile dysfunction: Randomized controlled trial. Andrology. 2021;9(4):1166-1175. doi:10.1111/andr.13010
6. Abdelrahman IFS, Raheem AA, Elkhiat Y, Aburahma AA, Abdel-Raheem T, Ghanem H. Safety and efficacy of botulinum neurotoxin in the treatment of erectile dysfunction refractory to phosphodiesterase inhibitors: Results of a randomized controlled trial. Andrology. 2022;10(2):254-261. doi:10.1111/andr.13104
7. Giuliano F, Joussain C, Denys P. Safety and Efficacy of Intracavernosal Injections of AbobotulinumtoxinA (Dysport®) as Add on Therapy to Phosphosdiesterase Type 5 Inhibitors or Prostaglandin E1 for Erectile Dysfunction—Case Studies. Toxins. 2019;11(5):283. doi:10.3390/toxins11050283

Supporting the P-Shot(R) procedure

1. Kumar CS. 265 Combined Treatment of Injecting Platelet Rich Plasma With Vacuum Pump for Penile Enlargement. The Journal of Sexual Medicine. 2017;14(1):S78. doi:10.1016/j.jsxm.2016.11.174
2. Littara A, Palmieri B, Rottigni V, Iannitti T. A clinical study to assess the effectiveness of a hyaluronic acid-based procedure for treatment of premature ejaculation. International Journal of Impotence Research. 2013;25(3). doi:10.1038/ijir.2013.13
3. Lee PJ, Jiang YH, Kuo HC. A novel management for postprostatectomy urinary incontinence: platelet-rich plasma urethral sphincter injection. Scientific Reports |. 123AD;11:5371. doi:10.1038/s41598-021-84923-1
4. Chung. A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction. Medical Sciences. 2019;7(9):91. doi:10.3390/medsci7090091
5. Casabona F, Gambelli I, Casabona F, Santi P, Santori G, Baldelli I. Autologous platelet-rich plasma (PRP) in chronic penile lichen sclerosus: the impact on tissue repair and patient quality of life. Int Urol Nephrol. 2017;49(4):573-580. doi:10.1007/s11255-017-1523-0
6. Bosma-Den Boer MM, Van Wetten ML, Pruimboom L. Chronic inflammatory diseases are stimulated by current lifestyle: How diet, stress levels and medication prevent our body from recovering. Nutrition and Metabolism. 2012;9. doi:10.1186/1743-7075-9-32
7. Customize: Priapus Shot® | P-Shot® | Official Website – Priapus Shot®. Accessed February 13, 2023. https://priapusshot.com/wp-admin/customize.php?url=https%3A%2F%2Fpriapusshot.com%2F
8. Ruffo A, Franco M, Illiano E, Stanojevic N. Effectiveness and safety of Platelet rich Plasma (PrP) cavernosal injections plus external shock wave treatment for penile erectile dysfunction: First results from a prospective, randomized, controlled, interventional study. European Urology Supplements. 2019;18(1):e1622-e1623. doi:10.1016/S1569-9056(19)31175-3
9. Calabrese EJ. Hormesis: Why it is important to toxicology and toxicologists. Environmental Toxicology and Chemistry. 2008;27(7):1451-1474. doi:10.1897/07-541.1
10. Pruimboom L, Muskiet FAJ. Intermittent living; the use of ancient challenges as a vaccine against the deleterious effects of modern life – A hypothesis. Medical Hypotheses. 2018;120:28-42. doi:10.1016/J.MEHY.2018.08.002
11. Shaher H, Fathi A, Elbashir S, Abdelbaki SA, Soliman T. Is Platelet Rich Plasma Safe And Effective In Treatment Of Erectile Dysfunction? Randomized Controlled Study. Urology. Published online February 2023:S0090429523000742. doi:10.1016/j.urology.2023.01.028
12. Chung E. medical sciences A Review of Current and Emerging Therapeutic Options for Erectile Dysfunction. Published online 2019:1-11.
13. Schirmann A, Boutin E, Faix A, Yiou R. Pilot study of intra-cavernous injections of platelet-rich plasma (P-shot®) in the treatment of vascular erectile dysfunction. Progrès en Urologie. Published online June 2022:S1166708722001300. doi:10.1016/j.purol.2022.05.002
14. Schirmann A, Boutin E, Faix A, Yiou R. Pilot study of intra-cavernous injections of platelet-rich plasma (P-shot®) in the treatment of vascular erectile dysfunction. Prog Urol. Published online June 10, 2022:S1166-7087(22)00130-0. doi:10.1016/j.purol.2022.05.002
15. Poulios E, Mykoniatis I, Pyrgidis N, et al. Platelet-Rich Plasma (PRP) Improves Erectile Function: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Journal of Sexual Medicine. 2021;18(5):926-935. doi:10.1016/j.jsxm.2021.03.008
16. Matz EL, Scarberry K, Terlecki R. Platelet-Rich Plasma and Cellular Therapies for Sexual Medicine and Beyond. Sexual Medicine Reviews. 2022;10(1):174-179. doi:10.1016/j.sxmr.2020.07.001
17. Masterson TA, Molina M, Ledesma B, et al. Platelet-rich Plasma for the Treatment of Erectile Dysfunction: A Prospective, Randomized, Double-blind, Placebo-controlled Clinical Trial. Journal of Urology. Published online April 30, 2023:10.1097/JU.0000000000003481. doi:10.1097/JU.0000000000003481
18. Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int J Mol Sci. 2020;21(20):7794. doi:10.3390/ijms21207794
19. Liu MC, Chang ML, Wang YC, Chen WH, Wu CC, Yeh SD. Revisiting the Regenerative Therapeutic Advances Towards Erectile Dysfunction. Cells. 2020;9(5):1250. doi:10.3390/cells9051250
20. Matz EL, Pearlman AM, Terlecki RP. Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions. Investig Clin Urol. 2018;59(1):61-65. doi:10.4111/icu.2018.59.1.61
21. Matz EL, Pearlman AM, Terlecki RP. Safety and feasibility of platelet rich fibrin matrix injections for treatment of common urologic conditions. Investigative and clinical urology. 2018;59(1):61-65. doi:10.4111/icu.2018.59.1.61
22. Israeli JM, Lokeshwar SD, Efimenko IV, Masterson TA, Ramasamy R. The potential of platelet-rich plasma injections and stem cell therapy for penile rejuvenation. Int J Impot Res. Published online November 6, 2021:1-8. doi:10.1038/s41443-021-00482-z
23. Raheem AA, Garaffa G, Raheem TA, et al. The role of vacuum pump therapy to mechanically straighten the penis in Peyronie’s disease. BJU International. 2010;106(8):1178-1180. doi:10.1111/j.1464-410X.2010.09365.x
24. Towe M, Peta A, Saltzman RG, Balaji N, Chu K, Ramasamy R. The use of combination regenerative therapies for erectile dysfunction: rationale and current status. Int J Impot Res. Published online July 12, 2021:1-4. doi:10.1038/s41443-021-00456-1
25. Garcia M, Fandel T, Lin G, et al. Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells. Published online 2010:14.
26. Garcia M, Fandel T, Lin G, et al. Treatment of erectile dysfunction in the obese type 2 diabetic ZDF rat with adipose tissue-derived stem cells. J Sex Med. 2010;7(1 Pt 1):89-98. Accessed June 14, 2022. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904063/
27. Siroky MB, Azadzoi KM. Vasculogenic Erectile Dysfunction: Newer Therapeutic Strategies. Journal of Urology. 2003;170(2S). doi:10.1097/01.ju.0000075361.35942.17

Supporting Vacuum Device

Welliver RC, Mechlin C, Goodwin B, Alukal JP, McCullough AR. A Pilot Study to Determine Penile Oxygen Saturation Before and After Vacuum Therapy in Patients with Erectile Dysfunction After Radical Prostatectomy. The Journal of Sexual Medicine. 2014;11(4):1071-1077. doi:10.1111/jsm.12445